ID   FLP27_CAEBR             Reviewed;          90 AA.
AC   A8WU84;
DT   23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   03-AUG-2022, entry version 54.
DE   RecName: Full=FMRFamide-like neuropeptides 27 {ECO:0000250|UniProtKB:Q18184};
DE   Contains:
DE     RecName: Full=EASAFGDIIGELKGKGLGGRMRF-amide {ECO:0000250|UniProtKB:Q18184};
DE   Flags: Precursor;
GN   Name=flp-27 {ECO:0000312|EMBL:CAP24046.1}; ORFNames=CBG02476;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1] {ECO:0000312|EMBL:CAP24046.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16 {ECO:0000312|EMBL:CAP24046.1};
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: FMRFamides and FMRFamide-like peptides are neuropeptides.
CC       {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the FARP (FMRFamide related peptide) family.
CC       {ECO:0000305}.
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DR   EMBL; HE601438; CAP24046.1; -; Genomic_DNA.
DR   RefSeq; XP_002630780.1; XM_002630734.1.
DR   AlphaFoldDB; A8WU84; -.
DR   STRING; 6238.CBG02476; -.
DR   EnsemblMetazoa; CBG02476.1; CBG02476.1; WBGene00025523.
DR   GeneID; 8572296; -.
DR   KEGG; cbr:CBG_02476; -.
DR   CTD; 8572296; -.
DR   WormBase; CBG02476; CBP06272; WBGene00025523; Cbr-flp-27.
DR   eggNOG; ENOG502TIKP; Eukaryota.
DR   HOGENOM; CLU_2471202_0_0_1; -.
DR   InParanoid; A8WU84; -.
DR   OMA; PVEYVQL; -.
DR   OrthoDB; 1855737at2759; -.
DR   Proteomes; UP000008549; Chromosome II.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Amidation; Cleavage on pair of basic residues; Neuropeptide;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   PROPEP          25..36
FT                   /evidence="ECO:0000250|UniProtKB:Q18184"
FT                   /id="PRO_0000392437"
FT   PEPTIDE         39..61
FT                   /note="EASAFGDIIGELKGKGLGGRMRF-amide"
FT                   /evidence="ECO:0000250|UniProtKB:Q18184"
FT                   /id="PRO_0000392438"
FT   PROPEP          65..90
FT                   /evidence="ECO:0000250|UniProtKB:Q18184"
FT                   /id="PRO_0000392439"
FT   MOD_RES         61
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000250|UniProtKB:Q18184"
SQ   SEQUENCE   90 AA;  9970 MW;  B6AFBAFB3BDCA7C4 CRC64;
     MFSFRKFLAF MLIVIALMAS FSSAQPIDEE RPIFMERREA SAFGDIIGEL KGKGLGGRMR
     FGKRSSSPSD ISMAELRAIY GGGPVEYVQL