FLP27_CAEEL
ID FLP27_CAEEL Reviewed; 89 AA.
AC Q18184;
DT 23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 2.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=FMRFamide-like neuropeptides 27;
DE Contains:
DE RecName: Full=EASAFGDIIGELKGKGLGGRMRF-amide {ECO:0000303|PubMed:19456328};
DE AltName: Full=Cae-flp-27 {ECO:0000303|PubMed:19456328};
DE Flags: Precursor;
GN Name=flp-27 {ECO:0000312|WormBase:C25H3.5}; ORFNames=C25H3.5;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Bristol N2;
RA Kohara Y., Shin-i T., Suzuki Y., Sugano S., Potdevin M., Thierry-Mieg Y.,
RA Thierry-Mieg D., Thierry-Mieg J.;
RT "The Caenorhabditis elegans transcriptome project, a complementary view of
RT the genome.";
RL Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3] {ECO:0000305}
RP PROTEIN SEQUENCE OF 38-60, MASS SPECTROMETRY, AND AMIDATION AT PHE-60.
RX PubMed=19456328; DOI=10.1111/j.1749-6632.2008.03624.x;
RA Clynen E., Husson S.J., Schoofs L.;
RT "Identification of new members of the (short) neuropeptide F family in
RT locusts and Caenorhabditis elegans.";
RL Ann. N. Y. Acad. Sci. 1163:60-74(2009).
RN [4] {ECO:0000305}
RP IDENTIFICATION.
RX PubMed=16076468; DOI=10.1016/j.ijpara.2005.05.010;
RA McVeigh P., Leech S., Mair G.R., Marks N.J., Geary T.G., Maule A.G.;
RT "Analysis of FMRFamide-like peptide (FLP) diversity in phylum Nematoda.";
RL Int. J. Parasitol. 35:1043-1060(2005).
CC -!- FUNCTION: FMRFamides and FMRFamide-like peptides are neuropeptides.
CC {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Each flp gene is expressed in a distinct set of
CC neurons. {ECO:0000305}.
CC -!- MASS SPECTROMETRY: Mass=2407.3; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:19456328};
CC -!- SIMILARITY: Belongs to the FARP (FMRFamide related peptide) family.
CC {ECO:0000305}.
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DR EMBL; BJ121162; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; FO080601; CCD65048.1; -; Genomic_DNA.
DR RefSeq; NP_495111.1; NM_062710.5.
DR AlphaFoldDB; Q18184; -.
DR BioGRID; 47763; 3.
DR STRING; 6239.C25H3.5; -.
DR EPD; Q18184; -.
DR PaxDb; Q18184; -.
DR PeptideAtlas; Q18184; -.
DR EnsemblMetazoa; C25H3.5.1; C25H3.5.1; WBGene00016114.
DR GeneID; 182924; -.
DR KEGG; cel:CELE_C25H3.5; -.
DR UCSC; C25H3.5; c. elegans.
DR CTD; 182924; -.
DR WormBase; C25H3.5; CE29185; WBGene00016114; flp-27.
DR eggNOG; ENOG502TIKP; Eukaryota.
DR HOGENOM; CLU_2471202_0_0_1; -.
DR InParanoid; Q18184; -.
DR OMA; PVEYVQL; -.
DR OrthoDB; 1855737at2759; -.
DR PRO; PR:Q18184; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00016114; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW Neuropeptide; Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000269|PubMed:19456328"
FT PROPEP 24..35
FT /evidence="ECO:0000269|PubMed:19456328"
FT /id="PRO_0000392440"
FT PEPTIDE 38..60
FT /note="EASAFGDIIGELKGKGLGGRMRF-amide"
FT /evidence="ECO:0000269|PubMed:19456328"
FT /id="PRO_0000392441"
FT PROPEP 64..89
FT /evidence="ECO:0000269|PubMed:19456328"
FT /id="PRO_0000392442"
FT MOD_RES 60
FT /note="Phenylalanine amide"
FT /evidence="ECO:0000269|PubMed:19456328"
SQ SEQUENCE 89 AA; 9910 MW; 945AD44994DE952F CRC64;
MFSLTQILTF LLVAITLMTF SSAQPIDEER PIFMERREAS AFGDIIGELK GKGLGGRMRF
GKRSSSPDIS LAEMRAIYGG DQSNIFNFK
