ID   FLP_LACCA               Reviewed;         219 AA.
AC   P29284;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-1992, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Probable transcriptional regulator flp;
GN   Name=flp;
OS   Lactobacillus casei.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lacticaseibacillus.
OX   NCBI_TaxID=1582;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=RNL7;
RX   PubMed=2113923; DOI=10.1093/oxfordjournals.jbchem.a123034;
RA   Natori Y., Kano Y., Imamoto F.;
RT   "Nucleotide sequences and genomic constitution of five tryptophan genes of
RT   Lactobacillus casei.";
RL   J. Biochem. 107:248-255(1990).
RN   [2]
RP   SIMILARITY TO CRP/FNR FAMILY.
RX   PubMed=8441692; DOI=10.1093/nar/21.3.753;
RA   Irvine A.S., Guest J.R.;
RT   "Lactobacillus casei contains a member of the CRP-FNR family.";
RL   Nucleic Acids Res. 21:753-753(1993).
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DR   EMBL; D00496; BAA00388.1; -; Genomic_DNA.
DR   PIR; S42348; JS0345.
DR   RefSeq; WP_003562610.1; NZ_JDWK01000191.1.
DR   AlphaFoldDB; P29284; -.
DR   SMR; P29284; -.
DR   STRING; 1582.AAW28_07610; -.
DR   GeneID; 61268423; -.
DR   eggNOG; COG0664; Bacteria.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   CDD; cd00038; CAP_ED; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR012318; HTH_CRP.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR018335; Tscrpt_reg_HTH_Crp-type_CS.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF13545; HTH_Crp_2; 1.
DR   PRINTS; PR00034; HTHCRP.
DR   SMART; SM00100; cNMP; 1.
DR   SMART; SM00419; HTH_CRP; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
DR   PROSITE; PS00042; HTH_CRP_1; 1.
DR   PROSITE; PS51063; HTH_CRP_2; 1.
PE   4: Predicted;
KW   DNA-binding; Transcription; Transcription regulation.
FT   CHAIN           1..219
FT                   /note="Probable transcriptional regulator flp"
FT                   /id="PRO_0000100160"
FT   DOMAIN          144..212
FT                   /note="HTH crp-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00387"
FT   DNA_BIND        191..210
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00387"
SQ   SEQUENCE   219 AA;  24102 MW;  6898945F6D914E2B CRC64;
     MAHSCTAVVP LFKNLNDEAR AAIDALTHER QVEKGTVLIS PDTAAHLLVV AHGKLKTYQL
     ATNGKEQLLR VDGVGDYEGE AGLLNIANPN VYTETLTAAT VCTISATDFQ QLLLKQPQIS
     LQLLTENARK MQALEKQAGY LGNDSINVRL THYLLDLRTA AGQDTVTVPM AWTQLADYLG
     TTPETVSRTL KRLAEEKLIE RSGKQVRILN AEDMEDFAW