ID   FLP_STAAC               Reviewed;         498 AA.
AC   Q5HDB2;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Protein flp;
DE   AltName: Full=FmtA-like protein;
GN   Name=flp; OrderedLocusNames=SACOL2445;
OS   Staphylococcus aureus (strain COL).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93062;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=COL;
RX   PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA   Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA   Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA   Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA   Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA   Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA   Fraser C.M.;
RT   "Insights on evolution of virulence and resistance from the complete genome
RT   analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT   a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT   strain.";
RL   J. Bacteriol. 187:2426-2438(2005).
RN   [2]
RP   FUNCTION.
RX   PubMed=10867231; DOI=10.1111/j.1574-6968.2000.tb09165.x;
RA   Komatsuzawa H., Choi G.H., Fujiwara T., Huang Y., Ohta K., Sugai M.,
RA   Suginaka H.;
RT   "Identification of a fmtA-like gene that has similarity to other PBPs and
RT   beta-lactamases in Staphylococcus aureus.";
RL   FEMS Microbiol. Lett. 188:35-39(2000).
CC   -!- FUNCTION: Its precise function is unknown. Has no penicillin-binding
CC       activity and is not involved in methicillin resistance.
CC       {ECO:0000269|PubMed:10867231}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- MISCELLANEOUS: Has two of three conserved motifs typically found in
CC       penicillin-binding proteins (PBPs) and beta-lactamases, but no
CC       penicillin-binding activity has been detected.
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DR   EMBL; CP000046; AAW38536.1; -; Genomic_DNA.
DR   RefSeq; WP_000208554.1; NC_002951.2.
DR   AlphaFoldDB; Q5HDB2; -.
DR   SMR; Q5HDB2; -.
DR   MEROPS; S12.011; -.
DR   EnsemblBacteria; AAW38536; AAW38536; SACOL2445.
DR   KEGG; sac:SACOL2445; -.
DR   HOGENOM; CLU_020027_4_2_9; -.
DR   OMA; KWQENYE; -.
DR   Proteomes; UP000000530; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.40.710.10; -; 1.
DR   InterPro; IPR001466; Beta-lactam-related.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   Pfam; PF00144; Beta-lactamase; 1.
DR   SUPFAM; SSF56601; SSF56601; 1.
PE   4: Predicted;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..498
FT                   /note="Protein flp"
FT                   /id="PRO_0000087304"
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        389..409
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        433..453
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        471..491
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   498 AA;  56467 MW;  FB51513A8DF02787 CRC64;
     MTTKKLYFLS ISIIIIVAIS IAIYITLNSN TKTRLTNDSQ QQIDTIIEHD LQKGHIPGAS
     ILIVKNGKVF LNKGYGYQDV DKKVKASPTT KYEIASNTKA FTGLAILKLA QEGRLNLNDA
     VSKHVPHFKM NYNGQNETIT IKQLLAQTSG IPSDITSEDS VTSKNNRLND VTRAIMGDEL
     HHKPGEEFEY SNMNYDLLGL IIQNVTKQSY TKYITNSWLK PLHMTHTSFK QTNYKSKHDA
     IGYELQGSTP VVSKPEFNLW DTPSAYMMTS TEDLEHWIKF QLNPPDKYKS LVQQSHKNLS
     STIGEPNANA YASGWFTNND EHLVFHSGTL DNFSSFILLN PKQNYGIVVL ANLNSEYVPK
     LVEHLNTQIV NHKRYSTVAS MLNQYKDQFN IVTVLMTTLI LLAFIFSAYR AWQMRHGQIL
     LRRSKRIAVL SWLSLCICIA LALILYALPY LILGSNNWSF VLTWLPIEIK LALITTLIAL
     FSTLIVILLF LHTKITKT