FLP_STAAN
ID FLP_STAAN Reviewed; 498 AA.
AC Q7A3Q5;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 97.
DE RecName: Full=Protein flp;
DE AltName: Full=FmtA-like protein;
GN Name=flp; OrderedLocusNames=SA2230;
OS Staphylococcus aureus (strain N315).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=158879;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=N315;
RX PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA Hiramatsu K.;
RT "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL Lancet 357:1225-1240(2001).
CC -!- FUNCTION: Its precise function is unknown. Has no penicillin-binding
CC activity and is not involved in methicillin resistance (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- MISCELLANEOUS: Has two of three conserved motifs typically found in
CC penicillin-binding proteins (PBPs) and beta-lactamases, but no
CC penicillin-binding activity has been detected. {ECO:0000250}.
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DR EMBL; BA000018; BAB43532.1; -; Genomic_DNA.
DR PIR; B99946; B99946.
DR RefSeq; WP_000208563.1; NC_002745.2.
DR PDB; 4GDN; X-ray; 3.20 A; A/B/C/D=30-370.
DR PDBsum; 4GDN; -.
DR AlphaFoldDB; Q7A3Q5; -.
DR SMR; Q7A3Q5; -.
DR MEROPS; S12.011; -.
DR EnsemblBacteria; BAB43532; BAB43532; BAB43532.
DR KEGG; sau:SA2230; -.
DR HOGENOM; CLU_020027_4_2_9; -.
DR OMA; YRDPWYG; -.
DR Proteomes; UP000000751; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 3.40.710.10; -; 1.
DR InterPro; IPR001466; Beta-lactam-related.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR Pfam; PF00144; Beta-lactamase; 1.
DR SUPFAM; SSF56601; SSF56601; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell membrane; Membrane; Transmembrane; Transmembrane helix.
FT CHAIN 1..498
FT /note="Protein flp"
FT /id="PRO_0000087306"
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 389..409
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 433..453
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 471..491
FT /note="Helical"
FT /evidence="ECO:0000255"
FT HELIX 43..54
FT /evidence="ECO:0007829|PDB:4GDN"
FT STRAND 57..65
FT /evidence="ECO:0007829|PDB:4GDN"
FT STRAND 68..79
FT /evidence="ECO:0007829|PDB:4GDN"
FT TURN 80..83
FT /evidence="ECO:0007829|PDB:4GDN"
FT STRAND 91..93
FT /evidence="ECO:0007829|PDB:4GDN"
FT HELIX 95..98
FT /evidence="ECO:0007829|PDB:4GDN"
FT HELIX 99..112
FT /evidence="ECO:0007829|PDB:4GDN"
FT HELIX 121..123
FT /evidence="ECO:0007829|PDB:4GDN"
FT HELIX 141..145
FT /evidence="ECO:0007829|PDB:4GDN"
FT HELIX 172..176
FT /evidence="ECO:0007829|PDB:4GDN"
FT STRAND 181..183
FT /evidence="ECO:0007829|PDB:4GDN"
FT HELIX 192..206
FT /evidence="ECO:0007829|PDB:4GDN"
FT HELIX 210..217
FT /evidence="ECO:0007829|PDB:4GDN"
FT TURN 218..223
FT /evidence="ECO:0007829|PDB:4GDN"
FT STRAND 237..239
FT /evidence="ECO:0007829|PDB:4GDN"
FT STRAND 243..246
FT /evidence="ECO:0007829|PDB:4GDN"
FT STRAND 249..252
FT /evidence="ECO:0007829|PDB:4GDN"
FT HELIX 259..261
FT /evidence="ECO:0007829|PDB:4GDN"
FT HELIX 262..265
FT /evidence="ECO:0007829|PDB:4GDN"
FT STRAND 267..270
FT /evidence="ECO:0007829|PDB:4GDN"
FT HELIX 271..282
FT /evidence="ECO:0007829|PDB:4GDN"
FT HELIX 286..296
FT /evidence="ECO:0007829|PDB:4GDN"
FT STRAND 303..305
FT /evidence="ECO:0007829|PDB:4GDN"
FT STRAND 309..312
FT /evidence="ECO:0007829|PDB:4GDN"
FT STRAND 315..318
FT /evidence="ECO:0007829|PDB:4GDN"
FT TURN 319..322
FT /evidence="ECO:0007829|PDB:4GDN"
FT STRAND 323..329
FT /evidence="ECO:0007829|PDB:4GDN"
FT STRAND 334..340
FT /evidence="ECO:0007829|PDB:4GDN"
FT HELIX 342..344
FT /evidence="ECO:0007829|PDB:4GDN"
FT STRAND 345..353
FT /evidence="ECO:0007829|PDB:4GDN"
FT HELIX 357..367
FT /evidence="ECO:0007829|PDB:4GDN"
SQ SEQUENCE 498 AA; 56496 MW; AE9A1DB1C73E0EBC CRC64;
MTTKKLYFLS ISIIILVAIS IAIYITLNSN TKTRLTNDSQ QQIDKIIEHD LQKGHIPGAS
ILIVKNGKVF LNKGYGYQDV DKKVKASPTT KYEIASNTKA FTGLAILKLA QEGRLNLNDD
VSKHVPHFKM NYNGQNETIT IKQLLAQTSG IPSDITSEDA VTNKNNRLND VTRAIMGDEL
HHKPGEEFEY SNMNYDLLGL IIQNVTKQSY TKYITNSWLK PLHMTHTSFK QTNNKSKHDA
IGYELQGSTP VVSKPEFNLW DTPSAYMMTS TEDLEHWIKF QLNPPDKYKS LVQQSHKNLS
STIGEPNANA YASGWFTNND EHLVFHSGTL DNFSSFILLN PKQNYGIVVL ANLNSEYVPK
LVEHLNTQIV NHKRYSTVAS ILNQYKDQFN IVTVLMTTLI LLAFIFSAYR AWQMRHGQIL
LRRSKRIAVL SWLTLCLCIA IALILYALPY LILGSNNWSF VLTWLPIEIK LALITTLIAL
FSTLIVILLF LHTKITKT
