ID   FLP_STAAR               Reviewed;         499 AA.
AC   Q6GDZ1;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Protein flp;
DE   AltName: Full=FmtA-like protein;
GN   Name=flp; OrderedLocusNames=SAR2531;
OS   Staphylococcus aureus (strain MRSA252).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=282458;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MRSA252;
RX   PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA   Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA   Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA   Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C.,
RA   Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z.,
RA   Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N.,
RA   Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A.,
RA   Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M.,
RA   Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
RT   "Complete genomes of two clinical Staphylococcus aureus strains: evidence
RT   for the rapid evolution of virulence and drug resistance.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
CC   -!- FUNCTION: Its precise function is unknown. Has no penicillin-binding
CC       activity and is not involved in methicillin resistance (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- MISCELLANEOUS: Has two of three conserved motifs typically found in
CC       penicillin-binding proteins (PBPs) and beta-lactamases, but no
CC       penicillin-binding activity has been detected. {ECO:0000250}.
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DR   EMBL; BX571856; CAG41512.1; -; Genomic_DNA.
DR   RefSeq; WP_000208581.1; NC_002952.2.
DR   AlphaFoldDB; Q6GDZ1; -.
DR   SMR; Q6GDZ1; -.
DR   MEROPS; S12.011; -.
DR   KEGG; sar:SAR2531; -.
DR   HOGENOM; CLU_020027_4_2_9; -.
DR   OMA; YRDPWYG; -.
DR   OrthoDB; 537440at2; -.
DR   Proteomes; UP000000596; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.40.710.10; -; 1.
DR   InterPro; IPR001466; Beta-lactam-related.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   Pfam; PF00144; Beta-lactamase; 1.
DR   SUPFAM; SSF56601; SSF56601; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..499
FT                   /note="Protein flp"
FT                   /id="PRO_0000087307"
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        389..409
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        433..453
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        471..491
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   499 AA;  56628 MW;  C00822567BA00DBE CRC64;
     MTTKKLYFLS ISIIILVAIS IAIYITLNSN TKTRLTNDSQ QQIDTIIEHD LQKGHIPGAS
     ILIVKNGKVF LNKGYGYQDV DKKVKASPTT KYEIASNTKA FTGLAILKLA QEGRLNLNDD
     VSKHVPHFKM NYNGQNETIT IKQLLAQTSG IPSDITSEDS VTNKNNRLND VTRAIMGDEL
     HHKPGEEFEY SNMNYDLLGL IIQNVTKQSY TKYITNSWLK PLHMTHTSFK QNNNKSKHDA
     IGYELQGSTP VVSKPEFNLW DTPSAYMMTS TEDLEHWIKF QLNPPDKYKS LVQQSHKNLS
     STIGEPNANA YASGWFTNND EHLVFHSGTL DNFSSFILLN PKQNYGIVVL ANLNSEYVPK
     LVEHLNTQIV NHKRYSTVAS MLNQYKDQFN IVTVLMTTLI LLAFIFSAYR AWQMRHGKII
     LRKSKLTTFL SWLTLCLCIA IALILYALPY LILGSNNWSF VLTWLPIEIK LTLTTAFIAL
     FSMLITLLLI LHTTTIKKP