ID   FLQE1_MYCTO             Reviewed;         301 AA.
AC   P9WQL6; L0TAL1; O07190; Q8VJE4;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 30.
DE   RecName: Full=Fluoroquinolones export ATP-binding protein MT2762;
DE            EC=7.6.2.-;
GN   OrderedLocusNames=MT2762;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Part of the ABC transporter complex involved in
CC       fluoroquinolones export. Probably responsible for energy coupling to
CC       the transport system (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: The complex is composed of 2 ATP-binding proteins and 2
CC       transmembrane proteins. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK47077.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AE000516; AAK47077.1; ALT_FRAME; Genomic_DNA.
DR   PIR; C70529; C70529.
DR   AlphaFoldDB; P9WQL6; -.
DR   SMR; P9WQL6; -.
DR   EnsemblBacteria; AAK47077; AAK47077; MT2762.
DR   KEGG; mtc:MT2762; -.
DR   HOGENOM; CLU_000604_1_2_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00005; ABC_tran; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance; ATP-binding; Cell membrane; Membrane;
KW   Nucleotide-binding; Translocase; Transport.
FT   CHAIN           1..301
FT                   /note="Fluoroquinolones export ATP-binding protein MT2762"
FT                   /id="PRO_0000426754"
FT   DOMAIN          18..246
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   BINDING         52..59
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ   SEQUENCE   301 AA;  33104 MW;  F259184F5AAFB4E1 CRC64;
     MTALNRAVAS ARVGTEVIRV RGLTFRYPKA AEPAVRGMEF TVGRGEIFGL LGPSGAGKST
     TQKLLIGLLR DHGGQATVWD KEPAEWGPDY YERIGVSFEL PNHYQKLTGY ENLRFFASLY
     AGATADPMQL LAAVGLADDA HTLVGKYSKG MQMRLTFARS LINDPELLFL DEPTSGLDPV
     NARKIKDIIV DLKARGRTIF LTTHDMATAD ELCDRVAFVV DGRIVALDSP TELKIARSRR
     RVRVEYRGDG GGLETAEFGM DGLADDPAFH SVLRNHHVET IHSREASLDD VFVEVTGRQL
     T