ID   FLQE2_MYCTU             Reviewed;         252 AA.
AC   P9WJB3; I1SB22; O07188; Q7D6S1;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 33.
DE   RecName: Full=Fluoroquinolones export permease protein Rv2686c;
GN   OrderedLocusNames=Rv2686c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=HN4711;
RX   PubMed=21653760; DOI=10.1128/jcm.00231-11;
RA   El Sahly H.M., Teeter L.D., Jost K.C. Jr., Dunbar D., Lew J., Graviss E.A.;
RT   "Incidence of moxifloxacin resistance in clinical Mycobacterium
RT   tuberculosis isolates in Houston, Texas.";
RL   J. Clin. Microbiol. 49:2942-2945(2011).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [3]
RP   FUNCTION IN FLUOROQUINOLONES EXPORT, AND SUBUNIT.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=15273144; DOI=10.1128/aac.48.8.3175-3178.2004;
RA   Pasca M.R., Guglierame P., Arcesi F., Bellinzoni M., De Rossi E.,
RA   Riccardi G.;
RT   "Rv2686c-Rv2687c-Rv2688c, an ABC fluoroquinolone efflux pump in
RT   Mycobacterium tuberculosis.";
RL   Antimicrob. Agents Chemother. 48:3175-3178(2004).
CC   -!- FUNCTION: Part of the ABC transporter complex Rv2686c/Rv2687c/Rv2688c
CC       involved in fluoroquinolones export. Confers resistance to
CC       ciprofloxacin and, to a lesser extent, norfloxacin, moxifloxacin and
CC       sparfloxacin. Probably responsible for the translocation of the
CC       substrate across the membrane. {ECO:0000269|PubMed:15273144}.
CC   -!- SUBUNIT: The complex is composed of 2 ATP-binding proteins (Rv2688c)
CC       and 2 transmembrane proteins (Rv2686c and Rv2687c).
CC       {ECO:0000305|PubMed:15273144}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; JN012502; AEG75294.1; -; Genomic_DNA.
DR   EMBL; AL123456; CCP45484.1; -; Genomic_DNA.
DR   PIR; A70529; A70529.
DR   RefSeq; NP_217202.1; NC_000962.3.
DR   RefSeq; WP_003413897.1; NZ_NVQJ01000017.1.
DR   AlphaFoldDB; P9WJB3; -.
DR   SMR; P9WJB3; -.
DR   STRING; 83332.Rv2686c; -.
DR   PaxDb; P9WJB3; -.
DR   DNASU; 888360; -.
DR   GeneID; 888360; -.
DR   KEGG; mtu:Rv2686c; -.
DR   PATRIC; fig|83332.111.peg.2992; -.
DR   TubercuList; Rv2686c; -.
DR   eggNOG; ENOG50316AC; Bacteria.
DR   OMA; LPTYWLY; -.
DR   PhylomeDB; P9WJB3; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015562; F:efflux transmembrane transporter activity; IMP:MTBBASE.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   GO; GO:0055085; P:transmembrane transport; IMP:MTBBASE.
PE   1: Evidence at protein level;
KW   Antibiotic resistance; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..252
FT                   /note="Fluoroquinolones export permease protein Rv2686c"
FT                   /id="PRO_0000390879"
FT   TRANSMEM        31..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        119..139
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        148..168
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        176..196
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        224..244
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   252 AA;  27144 MW;  D2C40E38626B58F7 CRC64;
     MRAISSLAGP RALAAFGRND IRGTYRDPLL VMLVIAPVIW TTGVALLTPL FTEMLARRYG
     FDLVGYYPLI LTAFLLLTSI IVAGALAAFL VLDDVDAGTM TALRVTPVPL SVFFGYRAAT
     VMVVTTIYVV ATMSCSGILE PGLVSSLIPI GLVAGLSAVV TLLLILAVAN NKIQGLAMVR
     ALGMLIAGLP CLPWFISSNW NLAFGVLPPY WAAKAFWVAS DHGTWWPYLV GGAVYNLAIV
     WVLFRRFRAK HA