ID   FLQE3_MYCTU             Reviewed;         237 AA.
AC   P9WJB1; L0TAC5; O07189; Q7D6S0;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 32.
DE   RecName: Full=Fluoroquinolones export permease protein Rv2687c;
GN   OrderedLocusNames=Rv2687c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   FUNCTION IN FLUOROQUINOLONES EXPORT, AND SUBUNIT.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=15273144; DOI=10.1128/aac.48.8.3175-3178.2004;
RA   Pasca M.R., Guglierame P., Arcesi F., Bellinzoni M., De Rossi E.,
RA   Riccardi G.;
RT   "Rv2686c-Rv2687c-Rv2688c, an ABC fluoroquinolone efflux pump in
RT   Mycobacterium tuberculosis.";
RL   Antimicrob. Agents Chemother. 48:3175-3178(2004).
CC   -!- FUNCTION: Part of the ABC transporter complex Rv2686c/Rv2687c/Rv2688c
CC       involved in fluoroquinolones export. Confers resistance to
CC       ciprofloxacin and, to a lesser extent, norfloxacin, moxifloxacin and
CC       sparfloxacin. Probably responsible for the translocation of the
CC       substrate across the membrane. {ECO:0000269|PubMed:15273144}.
CC   -!- SUBUNIT: The complex is composed of 2 ATP-binding proteins (Rv2688c)
CC       and 2 transmembrane proteins (Rv2686c and Rv2687c).
CC       {ECO:0000305|PubMed:15273144}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; AL123456; CCP45485.1; -; Genomic_DNA.
DR   PIR; B70529; B70529.
DR   RefSeq; NP_217203.1; NC_000962.3.
DR   RefSeq; WP_003413912.1; NZ_NVQJ01000017.1.
DR   AlphaFoldDB; P9WJB1; -.
DR   STRING; 83332.Rv2687c; -.
DR   PaxDb; P9WJB1; -.
DR   DNASU; 888446; -.
DR   GeneID; 888446; -.
DR   KEGG; mtu:Rv2687c; -.
DR   TubercuList; Rv2687c; -.
DR   eggNOG; COG1668; Bacteria.
DR   OMA; FMFVGTE; -.
DR   PhylomeDB; P9WJB1; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015562; F:efflux transmembrane transporter activity; IMP:MTBBASE.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   GO; GO:0055085; P:transmembrane transport; IMP:MTBBASE.
PE   1: Evidence at protein level;
KW   Antibiotic resistance; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..237
FT                   /note="Fluoroquinolones export permease protein Rv2687c"
FT                   /id="PRO_0000390880"
FT   TRANSMEM        20..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        49..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        96..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        119..139
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        147..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        199..219
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   237 AA;  25576 MW;  9A240CD234B4631E CRC64;
     MTRLVPALRL ELTLQVRQKF LHAAVFSGLI WLAVLLPMPV SLRPVAEPYV LVGDIAIIGF
     FFVGGTVFFE KQERTIGAIV STPLRFWEYL AAKLTVLLAI SLFVAVVVAT IVHGLGYHLL
     PLVAGIVLGT LLMLLVGFSS SLPFASVTDW FLAAVIPLAI MLAPPVVHYS GLWPNPVLYL
     IPTQGPLLLL GAAFDQVSLA PWQVGYAVVY PIVCAAGLCR AAKALFGRYV VQRSGVL