ID   FLRF_HIRME              Reviewed;           4 AA.
AC   P69137; P42561;
DT   15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   22-APR-2020, entry version 23.
DE   RecName: Full=FLRFamide;
OS   Hirudo medicinalis (Medicinal leech).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC   Hirudinea; Hirudinida; Hirudiniformes; Hirudinidae; Hirudo.
OX   NCBI_TaxID=6421;
RN   [1]
RP   PROTEIN SEQUENCE, AND AMIDATION AT PHE-4.
RX   PubMed=1686933; DOI=10.1016/0196-9781(91)90035-n;
RA   Evans B.D., Pohl J., Kartsonis M.A., Calabrese R.L.;
RT   "Identification of RFamide neuropeptides in the medicinal leech.";
RL   Peptides 12:897-908(1991).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the FARP (FMRFamide related peptide) family.
CC       {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Neuropeptide; Secreted.
FT   PEPTIDE         1..4
FT                   /note="FLRFamide"
FT                   /id="PRO_0000043652"
FT   MOD_RES         4
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:1686933"
SQ   SEQUENCE   4 AA;  582 MW;  69D40729A0000000 CRC64;
     FLRF