ID   FLTOP_DANRE             Reviewed;         213 AA.
AC   Q0P4F6;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 56.
DE   RecName: Full=Protein Flattop {ECO:0000305};
DE   AltName: Full=Cilia- and flagella-associated protein 126 {ECO:0000305};
GN   Name=cfap126 {ECO:0000250|UniProtKB:Q6P8X9};
GN   Synonyms=fltp {ECO:0000250|UniProtKB:Q6P8X9}; ORFNames=zgc:152916;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a regulator of cilium basal body docking and
CC       positioning in mono- and multiciliated cells.
CC       {ECO:0000250|UniProtKB:Q6P8X9}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body
CC       {ECO:0000250|UniProtKB:Q6P8X9}. Cell projection, cilium
CC       {ECO:0000250|UniProtKB:Q6P8X9}. Apical cell membrane
CC       {ECO:0000250|UniProtKB:Q6P8X9}. Cytoplasm, cytoskeleton, cilium axoneme
CC       {ECO:0000250|UniProtKB:Q3SZT6}. Note=Localizes to the apical cell
CC       membrane, the basal body and the primary cilium in monociliated node
CC       cells (By similarity). Microtubule inner protein (MIP) part of the
CC       dynein-decorated doublet microtubules (DMTs) in cilia axoneme (By
CC       similarity). {ECO:0000250|UniProtKB:Q3SZT6,
CC       ECO:0000250|UniProtKB:Q6P8X9}.
CC   -!- SIMILARITY: Belongs to the Flattop family. {ECO:0000305}.
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DR   EMBL; BC122100; AAI22101.1; -; mRNA.
DR   RefSeq; NP_001038883.1; NM_001045418.1.
DR   AlphaFoldDB; Q0P4F6; -.
DR   SMR; Q0P4F6; -.
DR   STRING; 7955.ENSDARP00000083775; -.
DR   PaxDb; Q0P4F6; -.
DR   GeneID; 751706; -.
DR   KEGG; dre:751706; -.
DR   CTD; 257177; -.
DR   ZFIN; ZDB-GENE-060825-357; cfap126.
DR   eggNOG; ENOG502S5M4; Eukaryota.
DR   InParanoid; Q0P4F6; -.
DR   OrthoDB; 1487116at2759; -.
DR   PhylomeDB; Q0P4F6; -.
DR   PRO; PR:Q0P4F6; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0016324; C:apical plasma membrane; ISS:UniProtKB.
DR   GO; GO:0005879; C:axonemal microtubule; ISS:UniProtKB.
DR   GO; GO:0036064; C:ciliary basal body; ISS:UniProtKB.
DR   GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR   GO; GO:0044782; P:cilium organization; ISS:UniProtKB.
DR   InterPro; IPR038797; Fltp.
DR   PANTHER; PTHR34639; PTHR34639; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cell projection; Cilium biogenesis/degradation; Cytoplasm;
KW   Cytoskeleton; Membrane; Reference proteome.
FT   CHAIN           1..213
FT                   /note="Protein Flattop"
FT                   /id="PRO_0000316974"
FT   REGION          127..213
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        139..153
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        154..213
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   213 AA;  24027 MW;  F26A7F0D9B93079D CRC64;
     MSTSYSANQY ESAFKSQKLQ NWTIPKQFKE RPSAAEGYTT FIATDRGHLL PGVRTKHRSA
     WPAFQGTWDL PRRIPPVSMN PTARSQVGQD RLMTWGQMKI TTKQAHKGPG DSQAMNRNSH
     DVENINVDQP AEQSKISIDP DENQPEKPKS QHIQDQSRPA SQQAQPIPEN LNINQSRPAS
     QRSQKAPSRP ATQQNQAEFR PPTHNSRPAS QEK