FLTOP_DROME
ID FLTOP_DROME Reviewed; 252 AA.
AC Q9W4I5; Q8T8T0;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 2.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Protein Flattop homolog {ECO:0000305};
DE AltName: Full=Cilia- and flagella-associated protein 126 {ECO:0000250|UniProtKB:Q6P8X9};
GN ORFNames=CG3062;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Testis;
RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J.W., Champe M.,
RA Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R.A.,
RA Gonzalez M., Guarin H., Kronmiller B., Li P.W., Liao G., Miranda A.,
RA Mungall C.J., Nunoo J., Pacleb J.M., Paragas V., Park S., Patel S.,
RA Phouanenavong S., Wan K.H., Yu C., Lewis S.E., Rubin G.M., Celniker S.E.;
RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the Flattop family. {ECO:0000305}.
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DR EMBL; AE014298; AAF45966.2; -; Genomic_DNA.
DR EMBL; AY075289; AAL68156.2; ALT_SEQ; mRNA.
DR RefSeq; NP_572177.2; NM_131949.3.
DR AlphaFoldDB; Q9W4I5; -.
DR BioGRID; 57913; 4.
DR IntAct; Q9W4I5; 2.
DR STRING; 7227.FBpp0070660; -.
DR PaxDb; Q9W4I5; -.
DR EnsemblMetazoa; FBtr0070692; FBpp0070660; FBgn0025612.
DR GeneID; 31396; -.
DR KEGG; dme:Dmel_CG3062; -.
DR UCSC; CG3062-RA; d. melanogaster.
DR FlyBase; FBgn0025612; CG3062.
DR VEuPathDB; VectorBase:FBgn0025612; -.
DR eggNOG; ENOG502S5M4; Eukaryota.
DR GeneTree; ENSGT00390000001092; -.
DR HOGENOM; CLU_079728_0_0_1; -.
DR InParanoid; Q9W4I5; -.
DR OMA; VSNWEYP; -.
DR OrthoDB; 1487116at2759; -.
DR PhylomeDB; Q9W4I5; -.
DR BioGRID-ORCS; 31396; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 31396; -.
DR PRO; PR:Q9W4I5; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0025612; Expressed in testis and 4 other tissues.
DR ExpressionAtlas; Q9W4I5; baseline and differential.
DR Genevisible; Q9W4I5; DM.
DR GO; GO:0036064; C:ciliary basal body; IBA:GO_Central.
DR GO; GO:0044782; P:cilium organization; IBA:GO_Central.
DR InterPro; IPR038797; Fltp.
DR PANTHER; PTHR34639; PTHR34639; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..252
FT /note="Protein Flattop homolog"
FT /id="PRO_0000371809"
FT REGION 177..252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..252
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 141
FT /note="R -> K (in Ref. 3; AAL68156)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 252 AA; 28858 MW; 6F64229DA96FCC44 CRC64;
MALHFSAQQF EGRFQSKRLN NWEYPRFSPP RPRGLQKNAK VVAANNGHLL PEVIKEGNSF
GQYRGTYELP RRITRAFCAH YDACLSGRYK FVDFPRDLCN CQRENRRALA CDQRLTLGHK
DDPYWMRERC QTKCEGLQKL RALSERSARC NRAKCDVVSE KTVKMTPKAI KTTGVATEKR
RRKRTITAFS KGRTALHPNE LTKPIPSSEK PAATVATPKD KPKDKPKDKE AGKKDKTKDK
GKEKERKAAK GH
