ID   FLTOP_NEMVE             Reviewed;         169 AA.
AC   A7RR34;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   03-AUG-2022, entry version 49.
DE   RecName: Full=Protein Flattop homolog {ECO:0000305};
DE   AltName: Full=Cilia- and flagella-associated protein 126 {ECO:0000250|UniProtKB:Q6P8X9};
GN   ORFNames=v1g200856;
OS   Nematostella vectensis (Starlet sea anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Edwardsiidae; Nematostella.
OX   NCBI_TaxID=45351;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CH2 X CH6;
RX   PubMed=17615350; DOI=10.1126/science.1139158;
RA   Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA   Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA   Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA   Technau U., Martindale M.Q., Rokhsar D.S.;
RT   "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT   genomic organization.";
RL   Science 317:86-94(2007).
CC   -!- FUNCTION: Acts as a regulator of cilium basal body docking and
CC       positioning in mono- and multiciliated cells.
CC       {ECO:0000250|UniProtKB:Q6P8X9}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body
CC       {ECO:0000250|UniProtKB:Q6P8X9}. Cell projection, cilium
CC       {ECO:0000250|UniProtKB:Q6P8X9}. Apical cell membrane
CC       {ECO:0000250|UniProtKB:Q6P8X9}. Note=Localizes to the apical cell
CC       membrane, the basal body and the primary cilium in monociliated node
CC       cells. {ECO:0000250|UniProtKB:Q6P8X9}.
CC   -!- SIMILARITY: Belongs to the Flattop family. {ECO:0000305}.
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DR   EMBL; DS469530; EDO46098.1; -; Genomic_DNA.
DR   RefSeq; XP_001638161.1; XM_001638111.1.
DR   AlphaFoldDB; A7RR34; -.
DR   SMR; A7RR34; -.
DR   STRING; 45351.EDO46098; -.
DR   EnsemblMetazoa; EDO46098; EDO46098; NEMVEDRAFT_v1g200856.
DR   GeneID; 5518189; -.
DR   KEGG; nve:5518189; -.
DR   eggNOG; ENOG502S5M4; Eukaryota.
DR   HOGENOM; CLU_108980_0_0_1; -.
DR   InParanoid; A7RR34; -.
DR   OMA; AMTENAQ; -.
DR   OrthoDB; 1487116at2759; -.
DR   PhylomeDB; A7RR34; -.
DR   Proteomes; UP000001593; Unassembled WGS sequence.
DR   GO; GO:0016324; C:apical plasma membrane; ISS:UniProtKB.
DR   GO; GO:0036064; C:ciliary basal body; ISS:UniProtKB.
DR   GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0044782; P:cilium organization; ISS:UniProtKB.
DR   InterPro; IPR038797; Fltp.
DR   PANTHER; PTHR34639; PTHR34639; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Cell projection; Cilium biogenesis/degradation; Cytoplasm;
KW   Cytoskeleton; Membrane; Reference proteome.
FT   CHAIN           1..169
FT                   /note="Protein Flattop homolog"
FT                   /id="PRO_0000371810"
FT   REGION          53..169
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        81..102
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        118..132
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   169 AA;  18527 MW;  8107860B31F0EA8A CRC64;
     MSTHFSANQY EKSFDAKRLQ NWEVPKHFKE HPSSLEGFTQ IISNDRGHIL EGIPRSSRSP
     WGEFVGTWDM TKPPLRTKTL KTKAMTENAQ QKRKSASPKQ EVARTPSPAK ASPRRDSPVQ
     ASPRNASPLQ GSPKKASAEK VCTPSPKAAS VSPVANKSPS PKLATPEPC