ID   FLTOP_XENLA             Reviewed;         180 AA.
AC   Q3KPS4;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 40.
DE   RecName: Full=Protein Flattop {ECO:0000305};
DE   AltName: Full=Cilia- and flagella-associated protein 126 {ECO:0000250|UniProtKB:Q6P8X9};
GN   Name=cfap126 {ECO:0000250|UniProtKB:Q6P8X9};
GN   Synonyms=fltp {ECO:0000250|UniProtKB:Q6P8X9};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a regulator of cilium basal body docking and
CC       positioning in mono- and multiciliated cells.
CC       {ECO:0000250|UniProtKB:Q6P8X9}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body
CC       {ECO:0000250|UniProtKB:Q6P8X9}. Cell projection, cilium
CC       {ECO:0000250|UniProtKB:Q6P8X9}. Apical cell membrane
CC       {ECO:0000250|UniProtKB:Q6P8X9}. Cytoplasm, cytoskeleton, cilium axoneme
CC       {ECO:0000250|UniProtKB:Q3SZT6}. Note=Localizes to the apical cell
CC       membrane, the basal body and the primary cilium in monociliated node
CC       cells (By similarity). Microtubule inner protein (MIP) part of the
CC       dynein-decorated doublet microtubules (DMTs) in cilia axoneme (By
CC       similarity). {ECO:0000250|UniProtKB:Q3SZT6,
CC       ECO:0000250|UniProtKB:Q6P8X9}.
CC   -!- SIMILARITY: Belongs to the Flattop family. {ECO:0000305}.
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DR   EMBL; BC106584; AAI06585.1; -; mRNA.
DR   RefSeq; NP_001089797.1; NM_001096328.1.
DR   AlphaFoldDB; Q3KPS4; -.
DR   SMR; Q3KPS4; -.
DR   DNASU; 734862; -.
DR   GeneID; 734862; -.
DR   KEGG; xla:734862; -.
DR   CTD; 734862; -.
DR   Xenbase; XB-GENE-6255000; cfap126.L.
DR   Proteomes; UP000186698; Chromosome 8L.
DR   Bgee; 734862; Expressed in testis and 18 other tissues.
DR   GO; GO:0016324; C:apical plasma membrane; ISS:UniProtKB.
DR   GO; GO:0005879; C:axonemal microtubule; ISS:UniProtKB.
DR   GO; GO:0036064; C:ciliary basal body; ISS:UniProtKB.
DR   GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR   GO; GO:0044782; P:cilium organization; ISS:UniProtKB.
DR   InterPro; IPR038797; Fltp.
DR   PANTHER; PTHR34639; PTHR34639; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cell projection; Cilium biogenesis/degradation; Cytoplasm;
KW   Cytoskeleton; Membrane; Reference proteome.
FT   CHAIN           1..180
FT                   /note="Protein Flattop"
FT                   /id="PRO_0000316975"
FT   REGION          111..180
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        111..151
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   180 AA;  19909 MW;  AA2FB455F94E7905 CRC64;
     MATHYSANQY QSAFTPKQLH CWSIPKDFKQ HPSTHDDYTQ FIANERGHLL AGVPRSQKNP
     WGTFLGTWDL PTKIPPSKLS LTSRSAEASK RLTNWIQNSE ELLHACNGLQ PQISGKASGK
     TDPPRDSSQG QQDPPVEESN KQTPLYRGRS KAESNRSSHR SVSSEKGGIT AGDKVLQAQS