ID   FLUF_NEUCR              Reviewed;         792 AA.
AC   O13360; Q7RVJ0;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 131.
DE   RecName: Full=Conidial development protein fluffy;
GN   Name=fl; ORFNames=B24M22.10, NCU08726;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND DEVELOPMENTAL STAGE.
RX   PubMed=9560395; DOI=10.1093/genetics/148.4.1813;
RA   Bailey L.A., Ebbole D.J.;
RT   "The fluffy gene of Neurospora crassa encodes a Gal4p-type C6 zinc cluster
RT   protein required for conidial development.";
RL   Genetics 148:1813-1820(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12655011; DOI=10.1093/nar/gkg293;
RA   Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D.,
RA   Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
RT   "What's in the genome of a filamentous fungus? Analysis of the Neurospora
RT   genome sequence.";
RL   Nucleic Acids Res. 31:1944-1954(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Required for conidiophore morphogenesis where it has a role
CC       in the budding phase. {ECO:0000269|PubMed:9560395}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- DEVELOPMENTAL STAGE: Levels are detected just prior to the
CC       developmental commitment to budding growth.
CC       {ECO:0000269|PubMed:9560395}.
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DR   EMBL; AF022648; AAB80932.1; -; Genomic_DNA.
DR   EMBL; AL390354; CAB99369.1; -; Genomic_DNA.
DR   EMBL; CM002237; EAA34351.1; -; Genomic_DNA.
DR   PIR; T08620; T08620.
DR   RefSeq; XP_963587.1; XM_958494.2.
DR   AlphaFoldDB; O13360; -.
DR   SMR; O13360; -.
DR   STRING; 5141.EFNCRP00000008598; -.
DR   PRIDE; O13360; -.
DR   EnsemblFungi; EAA34351; EAA34351; NCU08726.
DR   GeneID; 3879750; -.
DR   KEGG; ncr:NCU08726; -.
DR   VEuPathDB; FungiDB:NCU08726; -.
DR   HOGENOM; CLU_369688_0_0_1; -.
DR   InParanoid; O13360; -.
DR   OMA; NACLVCR; -.
DR   Proteomes; UP000001805; Chromosome 6, Linkage Group II.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0048315; P:conidium formation; IEA:UniProtKB-KW.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   2: Evidence at transcript level;
KW   Conidiation; DNA-binding; Metal-binding; Nucleus; Reference proteome;
KW   Sporulation; Transcription; Transcription regulation; Zinc.
FT   CHAIN           1..792
FT                   /note="Conidial development protein fluffy"
FT                   /id="PRO_0000114950"
FT   DNA_BIND        11..37
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          662..704
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   792 AA;  87887 MW;  90C9D32F0363C403 CRC64;
     MPRQHLTPNA CLVCRKKRTK CDGQMPCRRC RSRGEECAYE DKKWRTKDHL RSEIERLRNE
     QRQGHAVIRA LINDEQDWES FLSRIRGDES PEAIADWIRS IRNLFEPLQA ASSQSMGGLG
     APPTLLSPSQ ATASESSQLH RAASFAGIGS YNFGQGRVPF DQSTPRSSFS SDLSPTTPFS
     FREQADFIHA PQPMYPSSRR FSSSSLPSLP LRHSSQPLVP GIFNEPLPHT WTSITSDTQL
     VQRLLSRFFS APCSLLCFIP QSSFMKAFRE GDSRYCSEAL VNAILGKACK SYGTASNIVS
     RMAFGDAFIG EAKRLLATEP NHTNLPSTQA LAVLALAEIS EGKDDEAWDL AWASVRAAIT
     REQSFHVDQE FATARAVSYC GGFTLIHMLR LLTGRLDLNT SPFFMRLYQG SEETPEDEPQ
     NRIERGFALH MQFLAELEHC PPLPRFVFEI TTAVHTFASY NFSNAATAEE LEDAYGKCLD
     AYKRFEETFC LDMDTTPDLL FAQIWYHYCL LALLRPFVKS TASLRDSAMT TPRLRNDANP
     SDICQRSSEA IIFLTSTYQT RFSLGNPPEL LPHMLFAAVL YQVTLTPDPE HLSTIANDIK
     PELSESPVMM PSQAAFGAHG NSNLVPPPPM PFNNHGSYFP QPLSPVLKLE VRQAAPRRES
     SISLSSTFDS CGNRRPSDSF TSSTLTSHDA SERESSTSDT QSDFLPFFTS EPADLVTIGS
     LQLASMQHHG AVEATRLLRS LSTVKDLVGS TLDLETLAEA LPFPMGDLNT AVLYTGLGLQ
     RAPVEPMQVT GP