FLVC2_MOUSE
ID FLVC2_MOUSE Reviewed; 551 AA.
AC Q91X85;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 13-APR-2004, sequence version 2.
DT 25-MAY-2022, entry version 118.
DE RecName: Full=Feline leukemia virus subgroup C receptor-related protein 2;
DE AltName: Full=Calcium-chelate transporter;
DE Short=CCT;
GN Name=Flvcr2; Synonyms=Mfsd7c;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND CHARACTERIZATION.
RC TISSUE=Kidney;
RX PubMed=14729055; DOI=10.1016/j.yexcr.2003.10.002;
RA Brasier G., Tikellis C., Xuereb L., Craigie J., Casley D., Kovacs C.S.,
RA Fudge N.J., Kalnins R., Cooper M.E., Wookey P.J.;
RT "Novel hexad repeats conserved in a putative transporter with restricted
RT expression in cell types associated with growth, calcium exchange and
RT homeostasis.";
RL Exp. Cell Res. 293:31-42(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Salivary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-541, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Acts as an importer of heme. Also acts as a transporter for a
CC calcium-chelator complex, important for growth and calcium metabolism
CC (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Found in the kidney and in cells implicated in
CC rapid calcium exchange, namely the CNS, the eye, cardiomyocytes and
CC placenta in late term.
CC -!- DEVELOPMENTAL STAGE: Found in fetal chondrocytes and osteoclasts.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Feline
CC leukemia virus subgroup C receptor (TC 2.A.1.28.1) family.
CC {ECO:0000305}.
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DR EMBL; AY260574; AAP86635.1; -; mRNA.
DR EMBL; AY260576; AAP86637.1; -; mRNA.
DR EMBL; AY260575; AAP86636.1; -; mRNA.
DR EMBL; BC011209; AAH11209.1; -; mRNA.
DR CCDS; CCDS26062.1; -.
DR RefSeq; NP_663422.1; NM_145447.2.
DR AlphaFoldDB; Q91X85; -.
DR SMR; Q91X85; -.
DR BioGRID; 229955; 1.
DR STRING; 10090.ENSMUSP00000035569; -.
DR iPTMnet; Q91X85; -.
DR PhosphoSitePlus; Q91X85; -.
DR MaxQB; Q91X85; -.
DR PaxDb; Q91X85; -.
DR PRIDE; Q91X85; -.
DR ProteomicsDB; 273009; -.
DR DNASU; 217721; -.
DR GeneID; 217721; -.
DR KEGG; mmu:217721; -.
DR UCSC; uc007ohe.1; mouse.
DR CTD; 55640; -.
DR MGI; MGI:2384974; Flvcr2.
DR eggNOG; KOG2563; Eukaryota.
DR InParanoid; Q91X85; -.
DR OrthoDB; 702737at2759; -.
DR PhylomeDB; Q91X85; -.
DR TreeFam; TF314292; -.
DR BioGRID-ORCS; 217721; 1 hit in 73 CRISPR screens.
DR ChiTaRS; Mfsd7c; mouse.
DR PRO; PR:Q91X85; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q91X85; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0020037; F:heme binding; ISS:UniProtKB.
DR GO; GO:0015232; F:heme transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0097037; P:heme export; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Membrane; Phosphoprotein; Reference proteome; Repeat;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..551
FT /note="Feline leukemia virus subgroup C receptor-related
FT protein 2"
FT /id="PRO_0000084847"
FT TRANSMEM 108..128
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 148..168
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 175..195
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..219
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 275..295
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 333..353
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 372..392
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 401..421
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 424..444
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 459..479
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 490..510
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REPEAT 31..36
FT /note="1"
FT REPEAT 37..42
FT /note="2"
FT REPEAT 43..48
FT /note="3"
FT REPEAT 49..54
FT /note="4"
FT REPEAT 55..60
FT /note="5"
FT REPEAT 61..66
FT /note="6"
FT REPEAT 67..72
FT /note="7"
FT REPEAT 73..78
FT /note="8"
FT REGION 1..87
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 31..78
FT /note="8 X 6 AA tandem repeats of P-S-[VSG]-S-[VIAG]-
FT [HDRL]"
FT REGION 519..551
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..87
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 541
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CONFLICT 426
FT /note="I -> V (in Ref. 2; AAH11209)"
FT /evidence="ECO:0000305"
FT CONFLICT 452
FT /note="F -> L (in Ref. 2; AAH11209)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 551 AA; 60107 MW; 968F46696EEAE416 CRC64;
MVNESLNQEE SNDRPAPESE FQMDTSYSTQ PSGSIHPSVS GHPSVSGHPS VSGHPSVSIH
PSVSIDPSVS VRPSSSALPS TLAQPSGLTH HSSLVREDSV IKVSKRRWVV VLVFSCYSLC
NAFQWIQYGS INNIFMNFYG VSAFAIDWLS MCYMLTYIPL LLPVAWMLEK FGLRTIAITG
SALNCLGAWV KLGSLEPHLF PVTMVGQVIC SVAQVFILGM PSRIASVWFG ADEVSTACSV
AVFGNQLGIA IGFLVPPVLV PNIKDPEKLA YHISIMFYII GGVATFLFIL VIIVFKEKPK
HPPSRAQSLS YALATTDASY LSSIVRLFKN LNFVLLVITY GLNAGAFYAL STLLNRMVIL
HFPGEEVNAG RIGLTIVIAG MFGAMISGIW LDKSKTYKET TLVVYIMTLV GMVVYTFTLN
LNHLWIVFIT AGTLGFFMTG YLPLGFEFAV EFTYPESEGV SSGLLNVSAQ VFGIVFTISQ
GQIIDNHGTM FGNIFLCVFL ALGSALTAFI KSDLRRQRAN KDAPETKVQE EEEEEEGSNT
SKVPVVSEAH L
