FLVC2_RAT
ID FLVC2_RAT Reviewed; 546 AA.
AC P60815;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 13-APR-2004, sequence version 1.
DT 25-MAY-2022, entry version 93.
DE RecName: Full=Feline leukemia virus subgroup C receptor-related protein 2;
DE AltName: Full=Calcium-chelate transporter;
DE Short=CCT;
GN Name=Flvcr2;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Kidney;
RX PubMed=14729055; DOI=10.1016/j.yexcr.2003.10.002;
RA Brasier G., Tikellis C., Xuereb L., Craigie J., Casley D., Kovacs C.S.,
RA Fudge N.J., Kalnins R., Cooper M.E., Wookey P.J.;
RT "Novel hexad repeats conserved in a putative transporter with restricted
RT expression in cell types associated with growth, calcium exchange and
RT homeostasis.";
RL Exp. Cell Res. 293:31-42(2004).
CC -!- FUNCTION: Acts as an importer of heme. Also acts as a transporter for a
CC calcium-chelator complex, important for growth and calcium metabolism
CC (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Found in acidophil cells of the pituitary that
CC secrete growth hormone and prolactin.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Feline
CC leukemia virus subgroup C receptor (TC 2.A.1.28.1) family.
CC {ECO:0000305}.
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DR EMBL; AY260573; AAP86634.1; -; mRNA.
DR AlphaFoldDB; P60815; -.
DR SMR; P60815; -.
DR STRING; 10116.ENSRNOP00000011599; -.
DR UCSC; RGD:735098; rat.
DR RGD; 735098; Flvcr2.
DR eggNOG; KOG2563; Eukaryota.
DR InParanoid; P60815; -.
DR PhylomeDB; P60815; -.
DR ChiTaRS; Flvcr2; rat.
DR PRO; PR:P60815; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0020037; F:heme binding; ISS:UniProtKB.
DR GO; GO:0015232; F:heme transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0097037; P:heme export; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Membrane; Phosphoprotein; Reference proteome; Repeat;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..546
FT /note="Feline leukemia virus subgroup C receptor-related
FT protein 2"
FT /id="PRO_0000084848"
FT TRANSMEM 102..122
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 169..189
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 193..213
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 234..254
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 269..289
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 327..347
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 366..386
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 395..415
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 418..438
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 453..473
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 484..504
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REPEAT 31..36
FT /note="1"
FT REPEAT 37..42
FT /note="2"
FT REPEAT 43..48
FT /note="3"
FT REPEAT 49..54
FT /note="4"
FT REPEAT 55..60
FT /note="5"
FT REPEAT 61..66
FT /note="6"
FT REPEAT 67..72
FT /note="7"
FT REPEAT 73..78
FT /note="8; approximate"
FT REPEAT 79..84
FT /note="9; approximate"
FT REGION 1..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 31..84
FT /note="9 X 6 AA tandem repeats of P-S-[VS]-S-[VIAG]-[HD]"
FT REGION 511..546
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..82
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 535
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q91X85"
SQ SEQUENCE 546 AA; 59742 MW; 0E7B77D258295C45 CRC64;
MVNESLNQEE SNDRPVPESE FQADTSYSTQ PSVSIHPSVS GHPSVSIHPS VSGHPSVSID
PSVSVHPSSS AHPSTLAQPS GLTHPNELVK EDSVIKVSKR RWAVVLVFSC YSLCNAFQWI
QYGSINNIFM NFYGVSAFAI DWLSMCYMLT YIPLLLPVAW MLEKFGLRTI AITGSALNCL
GAWVKLGSLE PHLFPVTMVG QVICSVAQVF ILGMPSRIAS VWFGANEVST ACSMAVFGNQ
LGIAIGFLVP PVLVPNIKDQ EKLAYHISIM FYIIGGVATL LFILVIIVFK EKPKYPPSRA
QSLSYALATT DASYLSSIVR LFKNLNFVLL VITYGLNAGA FYALSTLLNR MVIMHFPGQE
VNAGRIGLTI VIAGMFGAMI SGIWLDKSKT YKETTLVVYI MTLVGMVVYT FTLNLNHLWI
VFITADSLGF FMTGYLPLGF EFAVELTYPE SEGVSSGLLN VSAQVFGIIF TISQGQIIDN
YGSVPGNIFL CVFLALGSAL TAFIKSDLRR QRANKDAPET KVQEEEEEEE ESNTSKVPTV
LSEAHL
