FLX1_YEAST
ID FLX1_YEAST Reviewed; 311 AA.
AC P40464; D6VVF3;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 168.
DE RecName: Full=Mitochondrial FAD carrier protein FLX1;
GN Name=FLX1; OrderedLocusNames=YIL134W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8631763; DOI=10.1074/jbc.271.13.7392;
RA Tzagoloff A., Jang J., Glerum D.M., Wu M.;
RT "FLX1 codes for a carrier protein involved in maintaining a proper balance
RT of flavin nucleotides in yeast mitochondria.";
RL J. Biol. Chem. 271:7392-7397(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169870;
RA Churcher C.M., Bowman S., Badcock K., Bankier A.T., Brown D.,
RA Chillingworth T., Connor R., Devlin K., Gentles S., Hamlin N., Harris D.E.,
RA Horsnell T., Hunt S., Jagels K., Jones M., Lye G., Moule S., Odell C.,
RA Pearson D., Rajandream M.A., Rice P., Rowley N., Skelton J., Smith V.,
RA Walsh S.V., Whitehead S., Barrell B.G.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome IX.";
RL Nature 387:84-87(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
CC -!- FUNCTION: Transport of FAD from the cytosol to the mitochondrial
CC matrix.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane
CC protein.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; Z38059; CAA86144.1; -; Genomic_DNA.
DR EMBL; L41168; AAA64973.1; -; Genomic_DNA.
DR EMBL; AY692757; AAT92776.1; -; Genomic_DNA.
DR EMBL; BK006942; DAA08419.1; -; Genomic_DNA.
DR PIR; S48400; S48400.
DR RefSeq; NP_012132.3; NM_001179482.3.
DR AlphaFoldDB; P40464; -.
DR SMR; P40464; -.
DR BioGRID; 34857; 307.
DR DIP; DIP-5662N; -.
DR IntAct; P40464; 2.
DR MINT; P40464; -.
DR STRING; 4932.YIL134W; -.
DR TCDB; 2.A.29.10.1; the mitochondrial carrier (mc) family.
DR CarbonylDB; P40464; -.
DR PaxDb; P40464; -.
DR PRIDE; P40464; -.
DR EnsemblFungi; YIL134W_mRNA; YIL134W; YIL134W.
DR GeneID; 854672; -.
DR KEGG; sce:YIL134W; -.
DR SGD; S000001396; FLX1.
DR VEuPathDB; FungiDB:YIL134W; -.
DR eggNOG; KOG0764; Eukaryota.
DR GeneTree; ENSGT00920000149145; -.
DR HOGENOM; CLU_015166_6_4_1; -.
DR InParanoid; P40464; -.
DR OMA; GLYFLWY; -.
DR BioCyc; YEAST:G3O-31385-MON; -.
DR Reactome; R-SCE-196757; Metabolism of folate and pterines.
DR PRO; PR:P40464; -.
DR Proteomes; UP000002311; Chromosome IX.
DR RNAct; P40464; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IDA:SGD.
DR GO; GO:0015230; F:FAD transmembrane transporter activity; IMP:SGD.
DR GO; GO:0008517; F:folic acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015883; P:FAD transport; IMP:SGD.
DR GO; GO:1904947; P:folate import into mitochondrion; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR InterPro; IPR044712; SLC25A32-like.
DR PANTHER; PTHR45683; PTHR45683; 1.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00926; MITOCARRIER.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..311
FT /note="Mitochondrial FAD carrier protein FLX1"
FT /id="PRO_0000090682"
FT TRANSMEM 13..33
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 77..97
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..149
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 183..203
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 230..250
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 266..286
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REPEAT 7..101
FT /note="Solcar 1"
FT REPEAT 123..210
FT /note="Solcar 2"
FT REPEAT 224..310
FT /note="Solcar 3"
SQ SEQUENCE 311 AA; 34409 MW; 9309FFD0E3BCBEE2 CRC64;
MVDHQWTPLQ KEVISGLSAG SVTTLVVHPL DLLKVRLQLS ATSAQKAHYG PFMVIKEIIR
SSANSGRSVT NELYRGLSIN LFGNAIAWGV YFGLYGVTKE LIYKSVAKPG ETQLKGVGND
HKMNSLIYLS AGASSGLMTA ILTNPIWVIK TRIMSTSKGA QGAYTSMYNG VQQLLRTDGF
QGLWKGLVPA LFGVSQGALY FAVYDTLKQR KLRRKRENGL DIHLTNLETI EITSLGKMVS
VTLVYPFQLL KSNLQSFRAN EQKFRLFPLI KLIIANDGFV GLYKGLSANL VRAIPSTCIT
FCVYENLKHR L
