FLXL2_ARATH
ID FLXL2_ARATH Reviewed; 359 AA.
AC Q84TD8; Q9ZW90;
DT 16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Protein FLX-like 2;
DE Short=AtFLXL2;
GN Name=FLXL2; Synonyms=FLL2; OrderedLocusNames=At1g67170; ORFNames=F5A8.8;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP FUNCTION, INTERACTION WITH FRI, AND DISRUPTION PHENOTYPE.
RX PubMed=21282526; DOI=10.1105/tpc.110.075911;
RA Choi K., Kim J., Hwang H.J., Kim S., Park C., Kim S.Y., Lee I.;
RT "The FRIGIDA complex activates transcription of FLC, a strong flowering
RT repressor in Arabidopsis, by recruiting chromatin modification factors.";
RL Plant Cell 23:289-303(2011).
RN [6]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=23864009; DOI=10.1038/ncomms3186;
RA Lee J., Amasino R.M.;
RT "Two FLX family members are non-redundantly required to establish the
RT vernalization requirement in Arabidopsis.";
RL Nat. Commun. 4:2186-2186(2013).
CC -!- FUNCTION: Has no transcriptional activation activity.
CC {ECO:0000269|PubMed:21282526, ECO:0000269|PubMed:23864009}.
CC -!- SUBUNIT: Interacts with FRI. {ECO:0000269|PubMed:21282526}.
CC -!- DISRUPTION PHENOTYPE: No suppression of FRI activity.
CC {ECO:0000269|PubMed:21282526, ECO:0000269|PubMed:23864009}.
CC -!- SIMILARITY: Belongs to the FLX family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD10662.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC004146; AAD10662.1; ALT_INIT; Genomic_DNA.
DR EMBL; CP002684; AEE34608.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM58321.1; -; Genomic_DNA.
DR EMBL; BT005883; AAO64818.1; -; mRNA.
DR EMBL; AK228253; BAF00201.1; -; mRNA.
DR PIR; F96695; F96695.
DR RefSeq; NP_001320766.1; NM_001334276.1.
DR RefSeq; NP_176888.2; NM_105387.5.
DR AlphaFoldDB; Q84TD8; -.
DR SMR; Q84TD8; -.
DR BioGRID; 28258; 10.
DR IntAct; Q84TD8; 10.
DR STRING; 3702.AT1G67170.1; -.
DR PaxDb; Q84TD8; -.
DR PRIDE; Q84TD8; -.
DR ProteomicsDB; 230589; -.
DR EnsemblPlants; AT1G67170.1; AT1G67170.1; AT1G67170.
DR EnsemblPlants; AT1G67170.2; AT1G67170.2; AT1G67170.
DR GeneID; 843037; -.
DR Gramene; AT1G67170.1; AT1G67170.1; AT1G67170.
DR Gramene; AT1G67170.2; AT1G67170.2; AT1G67170.
DR KEGG; ath:AT1G67170; -.
DR Araport; AT1G67170; -.
DR TAIR; locus:2033681; AT1G67170.
DR eggNOG; ENOG502QQDI; Eukaryota.
DR HOGENOM; CLU_051930_3_1_1; -.
DR InParanoid; Q84TD8; -.
DR OMA; HYNTAEN; -.
DR OrthoDB; 1233223at2759; -.
DR PhylomeDB; Q84TD8; -.
DR PRO; PR:Q84TD8; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q84TD8; baseline and differential.
DR GO; GO:0016604; C:nuclear body; IDA:TAIR.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0009908; P:flower development; IEA:UniProtKB-KW.
DR InterPro; IPR040353; FLX/FLX-like.
DR PANTHER; PTHR33405; PTHR33405; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Developmental protein; Differentiation; Flowering;
KW Reference proteome.
FT CHAIN 1..359
FT /note="Protein FLX-like 2"
FT /id="PRO_0000423736"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 303..359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 83..236
FT /evidence="ECO:0000255"
SQ SEQUENCE 359 AA; 39742 MW; F34A670620315D91 CRC64;
MESKGRIHPS HHHMRRPLPG PGGCIAHPET FGNHGAIPPS AAQGVYPSFN MLPPPEVMEQ
KFVAQHGELQ RLAIENQRLG GTHGSLRQEL AAAQHEIQML HAQIGSMKSE REQRMMGLAE
KVAKMETELQ KSEAVKLEMQ QARAEARSLV VAREELMSKV HQLTQELQKS RSDVQQIPAL
MSELENLRQE YQQCRATYDY EKKFYNDHLE SLQAMEKNYM TMAREVEKLQ AQLMNNANSD
RRAGGPYGNN INAEIDASGH QSGNGYYEDA FGPQGYIPQP VAGNATGPNS VVGAAQYPYQ
GVTQPGYFPQ RPGYNFPRGP PGSYDPTTRL PTGPYGAPFP PGPSNNTPYA GTHGNPSRR
