FLZ15_ARATH
ID FLZ15_ARATH Reviewed; 150 AA.
AC Q9FH22;
DT 10-OCT-2018, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=FCS-Like Zinc finger 15 {ECO:0000303|PubMed:24901469};
GN Name=FLZ15 {ECO:0000303|PubMed:24901469};
GN Synonyms=DUF581-17 {ECO:0000303|PubMed:24600465};
GN OrderedLocusNames=At5g49120 {ECO:0000312|Araport:AT5G49120};
GN ORFNames=K20J1.9 {ECO:0000312|EMBL:BAB10094.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10718197; DOI=10.1093/dnares/7.1.31;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence
RT features of the regions of 3,076,755 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:31-63(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND FUNCTION.
RX PubMed=24600465; DOI=10.3389/fpls.2014.00054;
RA Nietzsche M., Schiessl I., Boernke F.;
RT "The complex becomes more complex: protein-protein interactions of SnRK1
RT with DUF581 family proteins provide a framework for cell- and stimulus
RT type-specific SnRK1 signaling in plants.";
RL Front. Plant Sci. 5:54-54(2014).
RN [4]
RP ERRATUM OF PUBMED:24600465.
RX PubMed=25544057; DOI=10.3389/fpls.2014.00693;
RA Boernke F.;
RT "Corrigendum: The complex becomes more complex: protein-protein
RT interactions of SnRK1 with DUF581 family proteins provide a framework for
RT cell- and stimulus type-specific SnRK1 signaling in plants.";
RL Front. Plant Sci. 5:693-693(2014).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=24901469; DOI=10.1371/journal.pone.0099074;
RA Jamsheer K M., Laxmi A.;
RT "DUF581 is plant specific FCS-like zinc finger involved in protein-protein
RT interaction.";
RL PLoS ONE 9:E99074-E99074(2014).
RN [6]
RP INTERACTION WITH KIN10; KIN11; KINB1 AND KINB3, SUBUNIT, AND SUBCELLULAR
RP LOCATION.
RX PubMed=29945970; DOI=10.1074/jbc.ra118.002073;
RA Jamsheer K M., Shukla B.N., Jindal S., Gopan N., Mannully C.T., Laxmi A.;
RT "The FCS-like zinc finger scaffold of the kinase SnRK1 is formed by the
RT coordinated actions of the FLZ domain and intrinsically disordered
RT regions.";
RL J. Biol. Chem. 293:13134-13150(2018).
CC -!- FUNCTION: May act as an adapter to facilitate the interaction of SnRK1
CC complex with effector proteins, conferring tissue- and stimulus-type
CC specific differences in the SnRK1 regulation pathway.
CC {ECO:0000269|PubMed:24600465}.
CC -!- SUBUNIT: Interacts with KIN10 and KIN11 via its FLZ-type zinc finger
CC domain (PubMed:29945970). Interacts with KINB1 and KINB3 via its N-
CC terminal part (PubMed:29945970). Forms homodimer and heterodimer with
CC FLZ1, FLZ2 and FLZ7 in vitro (PubMed:29945970).
CC {ECO:0000269|PubMed:29945970}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, P-body {ECO:0000269|PubMed:29945970}.
CC -!- SIMILARITY: Belongs to the FLZ family. {ECO:0000305}.
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DR EMBL; AB023028; BAB10094.1; -; Genomic_DNA.
DR EMBL; CP002688; AED95773.1; -; Genomic_DNA.
DR RefSeq; NP_199723.1; NM_124289.4.
DR AlphaFoldDB; Q9FH22; -.
DR PaxDb; Q9FH22; -.
DR PRIDE; Q9FH22; -.
DR ProteomicsDB; 230629; -.
DR EnsemblPlants; AT5G49120.1; AT5G49120.1; AT5G49120.
DR GeneID; 834971; -.
DR Gramene; AT5G49120.1; AT5G49120.1; AT5G49120.
DR KEGG; ath:AT5G49120; -.
DR Araport; AT5G49120; -.
DR TAIR; locus:2155174; AT5G49120.
DR eggNOG; ENOG502S3GA; Eukaryota.
DR HOGENOM; CLU_143767_0_0_1; -.
DR InParanoid; Q9FH22; -.
DR OMA; VECRYRQ; -.
DR OrthoDB; 1576473at2759; -.
DR PhylomeDB; Q9FH22; -.
DR PRO; PR:Q9FH22; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FH22; baseline and differential.
DR GO; GO:0000932; C:P-body; IDA:UniProtKB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR007650; Zf-FLZ_dom.
DR Pfam; PF04570; zf-FLZ; 1.
DR PROSITE; PS51795; ZF_FLZ; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..150
FT /note="FCS-Like Zinc finger 15"
FT /id="PRO_0000445505"
FT ZN_FING 67..111
FT /note="FLZ-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01131"
FT REGION 12..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 129..150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 150 AA; 17170 MW; 8177D321111B8E4A CRC64;
MVGLSIVLEM TNNNNNNNNN NNNNNNKNPL SEGVLISPKV VNKANIIVTT AVTTDTTNLR
RCYQDSGFLE HCFLCRRKLL PAKDIYMYKG DRAFCSVECR SKQMIMDEEE SLRREYCSLM
DVKKKKFDSP ATAPSRYRRD PRNQAGGFAY
