FM1_ACTVI
ID FM1_ACTVI Reviewed; 533 AA.
AC P18477;
DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1990, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Fimbrial subunit type 1;
DE Flags: Precursor;
OS Actinomyces viscosus.
OC Bacteria; Actinobacteria; Actinomycetales; Actinomycetaceae; Actinomyces.
OX NCBI_TaxID=1656;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 31-56.
RC STRAIN=T14V;
RX PubMed=1970561; DOI=10.1128/jb.172.5.2462-2468.1990;
RA Yeung M.K., Cisar J.O.;
RT "Sequence homology between the subunits of two immunologically and
RT functionally distinct types of fimbriae of Actinomyces spp.";
RL J. Bacteriol. 172:2462-2468(1990).
CC -!- FUNCTION: Major fimbrial subunit of A.viscosus.
CC -!- SUBCELLULAR LOCATION: Secreted, cell wall {ECO:0000255|PROSITE-
CC ProRule:PRU00477}; Peptidoglycan-anchor {ECO:0000255|PROSITE-
CC ProRule:PRU00477}. Fimbrium.
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DR EMBL; M32067; AAA62572.1; -; Genomic_DNA.
DR PIR; A35259; A35259.
DR PDB; 3UXF; X-ray; 1.60 A; A=31-491.
DR PDBsum; 3UXF; -.
DR AlphaFoldDB; P18477; -.
DR SMR; P18477; -.
DR PRIDE; P18477; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0009289; C:pilus; IEA:UniProtKB-SubCell.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProt.
DR Gene3D; 2.60.40.10; -; 2.
DR InterPro; IPR026466; Fim_isopep_form_D2_dom.
DR InterPro; IPR032364; GramPos_pilinD1_N.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR019931; LPXTG_anchor.
DR InterPro; IPR006311; TAT_signal.
DR Pfam; PF00746; Gram_pos_anchor; 1.
DR Pfam; PF16555; GramPos_pilinD1; 1.
DR TIGRFAMs; TIGR04226; RrgB_K2N_iso_D2; 1.
DR PROSITE; PS50847; GRAM_POS_ANCHORING; 1.
DR PROSITE; PS51318; TAT; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell wall; Direct protein sequencing; Fimbrium;
KW Peptidoglycan-anchor; Secreted; Signal.
FT SIGNAL 1..30
FT /evidence="ECO:0000269|PubMed:1970561"
FT CHAIN 31..499
FT /note="Fimbrial subunit type 1"
FT /id="PRO_0000005601"
FT PROPEP 500..533
FT /note="Removed by sortase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00477"
FT /id="PRO_0000005602"
FT MOTIF 496..500
FT /note="LPXTG sorting signal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00477"
FT MOD_RES 499
FT /note="Pentaglycyl murein peptidoglycan amidated threonine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00477"
FT STRAND 37..39
FT /evidence="ECO:0007829|PDB:3UXF"
FT STRAND 47..51
FT /evidence="ECO:0007829|PDB:3UXF"
FT STRAND 81..88
FT /evidence="ECO:0007829|PDB:3UXF"
FT HELIX 94..102
FT /evidence="ECO:0007829|PDB:3UXF"
FT TURN 103..105
FT /evidence="ECO:0007829|PDB:3UXF"
FT HELIX 107..110
FT /evidence="ECO:0007829|PDB:3UXF"
FT HELIX 111..113
FT /evidence="ECO:0007829|PDB:3UXF"
FT STRAND 114..122
FT /evidence="ECO:0007829|PDB:3UXF"
FT STRAND 128..131
FT /evidence="ECO:0007829|PDB:3UXF"
FT TURN 133..135
FT /evidence="ECO:0007829|PDB:3UXF"
FT STRAND 138..147
FT /evidence="ECO:0007829|PDB:3UXF"
FT STRAND 158..165
FT /evidence="ECO:0007829|PDB:3UXF"
FT STRAND 173..179
FT /evidence="ECO:0007829|PDB:3UXF"
FT STRAND 183..185
FT /evidence="ECO:0007829|PDB:3UXF"
FT STRAND 188..193
FT /evidence="ECO:0007829|PDB:3UXF"
FT STRAND 204..211
FT /evidence="ECO:0007829|PDB:3UXF"
FT TURN 217..220
FT /evidence="ECO:0007829|PDB:3UXF"
FT STRAND 227..232
FT /evidence="ECO:0007829|PDB:3UXF"
FT STRAND 244..251
FT /evidence="ECO:0007829|PDB:3UXF"
FT TURN 258..260
FT /evidence="ECO:0007829|PDB:3UXF"
FT STRAND 261..267
FT /evidence="ECO:0007829|PDB:3UXF"
FT STRAND 269..278
FT /evidence="ECO:0007829|PDB:3UXF"
FT HELIX 280..291
FT /evidence="ECO:0007829|PDB:3UXF"
FT STRAND 298..305
FT /evidence="ECO:0007829|PDB:3UXF"
FT STRAND 314..324
FT /evidence="ECO:0007829|PDB:3UXF"
FT STRAND 346..348
FT /evidence="ECO:0007829|PDB:3UXF"
FT STRAND 352..365
FT /evidence="ECO:0007829|PDB:3UXF"
FT HELIX 372..375
FT /evidence="ECO:0007829|PDB:3UXF"
FT STRAND 379..388
FT /evidence="ECO:0007829|PDB:3UXF"
FT STRAND 391..394
FT /evidence="ECO:0007829|PDB:3UXF"
FT STRAND 401..403
FT /evidence="ECO:0007829|PDB:3UXF"
FT TURN 419..421
FT /evidence="ECO:0007829|PDB:3UXF"
FT STRAND 422..429
FT /evidence="ECO:0007829|PDB:3UXF"
FT STRAND 446..454
FT /evidence="ECO:0007829|PDB:3UXF"
FT STRAND 466..468
FT /evidence="ECO:0007829|PDB:3UXF"
FT HELIX 472..475
FT /evidence="ECO:0007829|PDB:3UXF"
FT TURN 476..478
FT /evidence="ECO:0007829|PDB:3UXF"
FT STRAND 481..487
FT /evidence="ECO:0007829|PDB:3UXF"
SQ SEQUENCE 533 AA; 56900 MW; F00299559C702FC4 CRC64;
MHSLNTRRGL GLAAAMTLAA GALVAPTGAA APADPNGSTI DPDAATTLTV HKCEQTDTNG
VKEGTGNEDP QAECKPVSDV EFTITKLNVD LTTYDGWKTL ADLKGDVVKA GALKSTTVQK
ITTGANGLAS FTDAQTEVGA YLVSETRTPD KVIPAEDFVV TLPMTNPQDT AKWNYNVHVY
PKNTLSGVDK QVTDKPAPGS GRDITYTITT SIPKVDYPGG ARIKRYEVVD RLDKRIKKEA
LTPVVKIVGQ NEVTLAETTD YTLITAEGKD HNWATIQLTE EGRRKASEAR YNGNGETKLQ
VTLNAKFDAA VNLEGDLSNT AGLIPNDSPN FTWDPNNPGT TTDIPGIPTT PVLSKYGKVV
LTKTGTDDLA DKTKYNGAQF QVYECTKTAS GATLRDSDPS TQTVDPLTIG GEKTFTTAGQ
GTVEINYLRA NDYVNGAKKD QLTDEDYYCL VETKAPEGYN LQADPLPFRV LAEKAEKKAA
TEVTVTDIPK NAGFRLPLTG ANGVIFLTIA GALLVAGGAV VAYANKRRHV AKH
