FM25A_HUMAN
ID FM25A_HUMAN Reviewed; 89 AA.
AC B3EWG3; B2RV02; Q5VTM1;
DT 21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2012, sequence version 1.
DT 03-AUG-2022, entry version 58.
DE RecName: Full=Protein FAM25A {ECO:0000305};
GN Name=FAM25A {ECO:0000312|HGNC:HGNC:23436};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SIMILARITY: Belongs to the FAM25 family. {ECO:0000305}.
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DR EMBL; AL136982; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471142; EAW80306.1; -; Genomic_DNA.
DR EMBL; BC171878; AAI71878.1; -; mRNA.
DR EMBL; BC171915; AAI71915.1; -; mRNA.
DR CCDS; CCDS44451.1; -.
DR RefSeq; NP_001131020.1; NM_001137548.2.
DR RefSeq; NP_001131021.1; NM_001137549.1.
DR RefSeq; NP_001139629.1; NM_001146157.2.
DR AlphaFoldDB; B3EWG3; -.
DR SMR; B3EWG3; -.
DR BioGRID; 135986; 18.
DR BioGRID; 568554; 18.
DR BioGRID; 569275; 25.
DR STRING; 9606.ENSP00000342790; -.
DR BioMuta; FAM25A; -.
DR MassIVE; B3EWG3; -.
DR PaxDb; B3EWG3; -.
DR PeptideAtlas; B3EWG3; -.
DR PRIDE; B3EWG3; -.
DR Antibodypedia; 67835; 14 antibodies from 7 providers.
DR DNASU; 644054; -.
DR Ensembl; ENST00000343959.5; ENSP00000342790.4; ENSG00000188100.9.
DR GeneID; 100133093; -.
DR GeneID; 643161; -.
DR GeneID; 644054; -.
DR KEGG; hsa:100133093; -.
DR KEGG; hsa:643161; -.
DR KEGG; hsa:644054; -.
DR MANE-Select; ENST00000343959.5; ENSP00000342790.4; NM_001146157.3; NP_001139629.1.
DR MANE-Select; ENST00000452267.2; ENSP00000413896.2; NM_001137549.2; NP_001131021.1.
DR MANE-Select; ENST00000617224.3; ENSP00000485370.1; NM_001137548.3; NP_001131020.1.
DR CTD; 100133093; -.
DR CTD; 643161; -.
DR CTD; 644054; -.
DR GeneCards; FAM25A; -.
DR HGNC; HGNC:23436; FAM25A.
DR HPA; ENSG00000188100; Tissue enhanced (esophagus, salivary gland, skin, vagina).
DR neXtProt; NX_B3EWG3; -.
DR OpenTargets; ENSG00000188100; -.
DR OpenTargets; ENSG00000276430; -.
DR VEuPathDB; HostDB:ENSG00000188100; -.
DR eggNOG; ENOG502SUWZ; Eukaryota.
DR HOGENOM; CLU_2454157_0_0_1; -.
DR InParanoid; B3EWG3; -.
DR OMA; WVHAVEE; -.
DR PhylomeDB; B3EWG3; -.
DR TreeFam; TF336933; -.
DR PathwayCommons; B3EWG3; -.
DR BioGRID-ORCS; 100133093; 355 hits in 605 CRISPR screens.
DR BioGRID-ORCS; 643161; 134 hits in 988 CRISPR screens.
DR BioGRID-ORCS; 644054; 20 hits in 265 CRISPR screens.
DR Pharos; B3EWG3; Tdark.
DR PRO; PR:B3EWG3; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; B3EWG3; protein.
DR Bgee; ENSG00000188100; Expressed in lower esophagus mucosa and 77 other tissues.
DR InterPro; IPR023243; FAM25.
DR PANTHER; PTHR34994; PTHR34994; 1.
DR Pfam; PF15825; FAM25; 1.
DR PRINTS; PR02048; PROTEINF25.
PE 3: Inferred from homology;
KW Reference proteome.
FT CHAIN 1..89
FT /note="Protein FAM25A"
FT /id="PRO_0000270919"
FT VARIANT 35
FT /note="V -> L (in dbSNP:rs7079587)"
FT /id="VAR_054062"
SQ SEQUENCE 89 AA; 9320 MW; 991CD0D86C55019B CRC64;
MLGGLGKLAA EGLAHRTEKA TEGAIHAVEE VVKEVVGHAK ETGEKAIAEA IKKAQESGDK
KMKEITETVT NTVTNAITHA AESLDKLGQ
