FM25C_HUMAN
ID FM25C_HUMAN Reviewed; 89 AA.
AC B3EWG5; B2RV02; Q5VTM1;
DT 21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2012, sequence version 1.
DT 03-AUG-2022, entry version 59.
DE RecName: Full=Protein FAM25C {ECO:0000305};
GN Name=FAM25C {ECO:0000312|HGNC:HGNC:23586};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC B3EWG5; Q8N2F6-2: ARMC10; NbExp=5; IntAct=EBI-14240149, EBI-12902762;
CC B3EWG5; Q9UH62: ARMCX3; NbExp=3; IntAct=EBI-14240149, EBI-717832;
CC B3EWG5; Q9P0S2: COX16; NbExp=3; IntAct=EBI-14240149, EBI-6570716;
CC B3EWG5; P21695: GPD1; NbExp=3; IntAct=EBI-14240149, EBI-713346;
CC B3EWG5; P15814: IGLL1; NbExp=3; IntAct=EBI-14240149, EBI-1222221;
CC B3EWG5; Q6PF15: KLHL35; NbExp=3; IntAct=EBI-14240149, EBI-9477654;
CC B3EWG5; P31025: LCN1; NbExp=3; IntAct=EBI-14240149, EBI-1052433;
CC B3EWG5; P80188: LCN2; NbExp=3; IntAct=EBI-14240149, EBI-11911016;
CC B3EWG5; Q9NQG6: MIEF1; NbExp=3; IntAct=EBI-14240149, EBI-740987;
CC B3EWG5; Q96C03-3: MIEF2; NbExp=3; IntAct=EBI-14240149, EBI-11988931;
CC B3EWG5; P45877: PPIC; NbExp=3; IntAct=EBI-14240149, EBI-953909;
CC B3EWG5; P30405: PPIF; NbExp=3; IntAct=EBI-14240149, EBI-5544229;
CC B3EWG5; P06703: S100A6; NbExp=3; IntAct=EBI-14240149, EBI-352877;
CC B3EWG5; Q13596: SNX1; NbExp=3; IntAct=EBI-14240149, EBI-2822329;
CC B3EWG5; Q9Y2W6: TDRKH; NbExp=3; IntAct=EBI-14240149, EBI-12842466;
CC B3EWG5; Q6UXN7: TOMM20L; NbExp=3; IntAct=EBI-14240149, EBI-11954062;
CC B3EWG5; P49638: TTPA; NbExp=3; IntAct=EBI-14240149, EBI-10210710;
CC B3EWG5; Q9H8U3: ZFAND3; NbExp=3; IntAct=EBI-14240149, EBI-725171;
CC -!- SIMILARITY: Belongs to the FAM25 family. {ECO:0000305}.
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DR EMBL; AL603966; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC146955; AAI46956.1; -; mRNA.
DR EMBL; BC146968; AAI46969.1; -; mRNA.
DR EMBL; BC146972; AAI46973.1; -; mRNA.
DR EMBL; BC146989; AAI46990.1; -; mRNA.
DR EMBL; BC146990; AAI46991.1; -; mRNA.
DR EMBL; BC146991; AAI46992.1; -; mRNA.
DR EMBL; BC147022; AAI47023.1; -; mRNA.
DR EMBL; BC147026; AAI47027.1; -; mRNA.
DR CCDS; CCDS76299.1; -.
DR RefSeq; NP_001131020.1; NM_001137548.2.
DR RefSeq; NP_001131021.1; NM_001137549.1.
DR RefSeq; NP_001139629.1; NM_001146157.2.
DR AlphaFoldDB; B3EWG5; -.
DR SMR; B3EWG5; -.
DR BioGRID; 135986; 18.
DR BioGRID; 568554; 18.
DR BioGRID; 569275; 25.
DR IntAct; B3EWG5; 18.
DR BioMuta; FAM25C; -.
DR MassIVE; B3EWG5; -.
DR PRIDE; B3EWG5; -.
DR DNASU; 644054; -.
DR Ensembl; ENST00000617224.3; ENSP00000485370.1; ENSG00000276430.3.
DR Ensembl; ENST00000672360.1; ENSP00000500536.1; ENSG00000288481.1.
DR GeneID; 100133093; -.
DR GeneID; 643161; -.
DR GeneID; 644054; -.
DR KEGG; hsa:100133093; -.
DR KEGG; hsa:643161; -.
DR KEGG; hsa:644054; -.
DR MANE-Select; ENST00000343959.5; ENSP00000342790.4; NM_001146157.3; NP_001139629.1.
DR MANE-Select; ENST00000452267.2; ENSP00000413896.2; NM_001137549.2; NP_001131021.1.
DR MANE-Select; ENST00000617224.3; ENSP00000485370.1; NM_001137548.3; NP_001131020.1.
DR CTD; 100133093; -.
DR CTD; 643161; -.
DR CTD; 644054; -.
DR GeneCards; FAM25C; -.
DR HGNC; HGNC:23586; FAM25C.
DR HPA; ENSG00000276430; Tissue enhanced (esophagus, salivary gland, skin, vagina).
DR neXtProt; NX_B3EWG5; -.
DR OpenTargets; ENSG00000188100; -.
DR OpenTargets; ENSG00000276430; -.
DR VEuPathDB; HostDB:ENSG00000276430; -.
DR HOGENOM; CLU_2454157_0_0_1; -.
DR InParanoid; B3EWG5; -.
DR OMA; AITHVME; -.
DR PhylomeDB; B3EWG5; -.
DR PathwayCommons; B3EWG5; -.
DR SignaLink; B3EWG5; -.
DR BioGRID-ORCS; 100133093; 355 hits in 605 CRISPR screens.
DR BioGRID-ORCS; 643161; 134 hits in 988 CRISPR screens.
DR BioGRID-ORCS; 644054; 20 hits in 265 CRISPR screens.
DR Pharos; B3EWG5; Tdark.
DR PRO; PR:B3EWG5; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; B3EWG5; protein.
DR Bgee; ENSG00000276430; Expressed in skin of leg and 54 other tissues.
DR InterPro; IPR023243; FAM25.
DR PANTHER; PTHR34994; PTHR34994; 1.
DR Pfam; PF15825; FAM25; 1.
DR PRINTS; PR02048; PROTEINF25.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..89
FT /note="Protein FAM25C"
FT /id="PRO_0000416047"
SQ SEQUENCE 89 AA; 9320 MW; 991CD0D86C55019B CRC64;
MLGGLGKLAA EGLAHRTEKA TEGAIHAVEE VVKEVVGHAK ETGEKAIAEA IKKAQESGDK
KMKEITETVT NTVTNAITHA AESLDKLGQ
