ID   AL2CL_BOVIN             Reviewed;         953 AA.
AC   A6QP75;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=ALS2 C-terminal-like protein;
GN   Name=ALS2CL;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal skin;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a guanine nucleotide exchange factor (GEF) for Rab5
CC       GTPase. Regulates the ALS2-mediated endosome dynamics (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. Forms a heteromeric complex with ALS2. Interacts
CC       with ALS2 and RAB5A (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Note=Distributed onto the vesicular
CC       compartments in the cytoplasm with strong punctated staining.
CC       Colocalizes with RAB5A onto the vesicular/membranous compartments in
CC       the cytoplasm, particularly to the leading edges of the cells (By
CC       similarity). {ECO:0000250}.
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DR   EMBL; BC149185; AAI49186.1; -; mRNA.
DR   RefSeq; NP_001095958.1; NM_001102488.1.
DR   AlphaFoldDB; A6QP75; -.
DR   SMR; A6QP75; -.
DR   STRING; 9913.ENSBTAP00000023681; -.
DR   PaxDb; A6QP75; -.
DR   PRIDE; A6QP75; -.
DR   Ensembl; ENSBTAT00000023681; ENSBTAP00000023681; ENSBTAG00000017812.
DR   GeneID; 506969; -.
DR   KEGG; bta:506969; -.
DR   CTD; 259173; -.
DR   VEuPathDB; HostDB:ENSBTAG00000017812; -.
DR   VGNC; VGNC:25852; ALS2CL.
DR   eggNOG; KOG0231; Eukaryota.
DR   GeneTree; ENSGT00940000161305; -.
DR   InParanoid; A6QP75; -.
DR   OMA; CYKCHWQ; -.
DR   OrthoDB; 37470at2759; -.
DR   Proteomes; UP000009136; Chromosome 22.
DR   Bgee; ENSBTAG00000017812; Expressed in isthmus of fallopian tube and 103 other tissues.
DR   ExpressionAtlas; A6QP75; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0031410; C:cytoplasmic vesicle; IBA:GO_Central.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0031267; F:small GTPase binding; IBA:GO_Central.
DR   GO; GO:0016197; P:endosomal transport; IBA:GO_Central.
DR   GO; GO:0007032; P:endosome organization; IBA:GO_Central.
DR   GO; GO:0043087; P:regulation of GTPase activity; IBA:GO_Central.
DR   Gene3D; 1.20.1050.80; -; 1.
DR   Gene3D; 1.20.900.10; -; 1.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR003409; MORN.
DR   InterPro; IPR003123; VPS9.
DR   InterPro; IPR037191; VPS9_dom_sf.
DR   Pfam; PF02493; MORN; 6.
DR   Pfam; PF02204; VPS9; 1.
DR   SMART; SM00698; MORN; 7.
DR   SUPFAM; SSF109993; SSF109993; 1.
DR   SUPFAM; SSF48065; SSF48065; 1.
DR   PROSITE; PS51205; VPS9; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; GTPase activation; Reference proteome; Repeat.
FT   CHAIN           1..953
FT                   /note="ALS2 C-terminal-like protein"
FT                   /id="PRO_0000313848"
FT   REPEAT          358..380
FT                   /note="MORN 1"
FT   REPEAT          381..403
FT                   /note="MORN 2"
FT   REPEAT          409..431
FT                   /note="MORN 3"
FT   REPEAT          432..454
FT                   /note="MORN 4"
FT   REPEAT          459..481
FT                   /note="MORN 5"
FT   REPEAT          483..505
FT                   /note="MORN 6"
FT   REPEAT          506..528
FT                   /note="MORN 7"
FT   REPEAT          529..552
FT                   /note="MORN 8"
FT   DOMAIN          796..942
FT                   /note="VPS9"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00550"
SQ   SEQUENCE   953 AA;  107869 MW;  3BF7CB1A191B985E CRC64;
     MCSPEEAALL RLEEVFSATL ARINSLVFQP LLEAGPEASD PWGRECLQLL QQLHSSSQQL
     WDVMEESLHS LRERLRRPEA VGLESLLLLQ SADRVLQVHL EYIESYTCCV AVQAFQKAVK
     RRSEYWRGQR KALRQVLSGL SSEGSVGTAL LQALRQPLAH HVQQYVLLLL SLGDTVGECH
     PTRELVIHAA SLFGDLQSFM RQELDQATAT QALWPTLSSR LRDVLCTPAR RLLQDSQDVP
     VTVTPLRAER VLLFDDALVL LQGHNIHTFD LKLVWVEPGQ DRCTFHLLTP EEGFSFCSKD
     PQGLVVWQWK VTQAVCQALR GKKDFPVLGA GLEPSEPPTC RCGAYTFHAE GRFCQATYEG
     EWYWGRPHGK GTLKWPDGRN HVGDFCQGLE HGFGIRLVPQ ASEDKFDCYK CHWWEGSMCG
     YGICEYSTSE VYKGYFQEGL RHGFGVLESA PQAPRPLRYT GHWERGQRSG YGVEEDSDRG
     ERYIGMWQAD QRHGPGVMVT QAGVCYQGTF QADKMVGPGI LLSDDDSLYE GTFTRDLTLV
     GKGKVTFPNG FTLEGSFGSV SGRGLHTQGV LDTAALPPDP SSTCKRQLGQ GVFPVESRWQ
     GVYGAFRDFV RAGCPGDLRE ALLGFHVQSS RELRKSQEYL CCERTCPEDQ AGRMEDLLEE
     LLQHREPEAL QQCLRKALSN SLHPLGKLLR TLMLTFQATY AGIGANKHLQ GLAQEEVKQH
     AQELWAAYRG LLQVALQRKG QAPEEDEDAE TRDLRVHSLV LPLVLPSFYS ELFTLYLLLH
     EREDSLYSQG ITHLSLFPDA RLLEFLDVQK HLWPLKDLTL TTNQRYSLVR DKCFLSATEC
     LQKMITTVDP REKLEVLERT YGEIEATVSR VLGREHKLPM DDLLPLLIYV VSRAQIQHLG
     AEIHLIRDMM DPLHTGGLYD FLLTALESCY EHIQKEDMRL HRLPSRWSSR EPW