FMC1_ECOH1
ID FMC1_ECOH1 Reviewed; 170 AA.
AC E3PPC4; P02971;
DT 08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT 11-JAN-2011, sequence version 1.
DT 03-AUG-2022, entry version 70.
DE RecName: Full=CFA/I fimbrial subunit B;
DE AltName: Full=CFA/I antigen;
DE AltName: Full=CFA/I pilin;
DE AltName: Full=Colonization factor antigen I subunit B;
DE Flags: Precursor;
GN Name=cfaB; OrderedLocusNames=ETEC_p948_0400;
OS Escherichia coli O78:H11 (strain H10407 / ETEC).
OG Plasmid p948.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=316401;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=H10407 / ETEC;
RX PubMed=2564374; DOI=10.1128/iai.57.4.1126-1130.1989;
RA Karjalainen T.K., Evans D.G., So M., Lee C.-H.;
RT "Molecular cloning and nucleotide sequence of the colonization factor
RT antigen I gene of Escherichia coli.";
RL Infect. Immun. 57:1126-1130(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H10407 / ETEC; PLASMID=p948;
RX PubMed=20802035; DOI=10.1128/jb.00710-10;
RA Crossman L.C., Chaudhuri R.R., Beatson S.A., Wells T.J., Desvaux M.,
RA Cunningham A.F., Petty N.K., Mahon V., Brinkley C., Hobman J.L.,
RA Savarino S.J., Turner S.M., Pallen M.J., Penn C.W., Parkhill J.,
RA Turner A.K., Johnson T.J., Thomson N.R., Smith S.G., Henderson I.R.;
RT "A commensal gone bad: complete genome sequence of the prototypical
RT enterotoxigenic Escherichia coli strain H10407.";
RL J. Bacteriol. 192:5822-5831(2010).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-170.
RC STRAIN=H10407 / ETEC;
RX PubMed=6124420; DOI=10.1111/j.1432-1033.1982.tb06597.x;
RA Klemm P.;
RT "Primary structure of the CFA1 fimbrial protein from human enterotoxigenic
RT Escherichia coli strains.";
RL Eur. J. Biochem. 124:339-348(1982).
RN [4]
RP PROTEIN SEQUENCE OF 24-42.
RC STRAIN=H10407 / ETEC;
RX PubMed=2572583; DOI=10.1128/jb.171.11.6372-6374.1989;
RA Hall R.H., Maneval D.R. Jr., Collins J.H., Theibert J.L., Levine M.M.;
RT "Purification and analysis of colonization factor antigen I, coli surface
RT antigen 1, and coli surface antigen 3 fimbriae from enterotoxigenic
RT Escherichia coli.";
RL J. Bacteriol. 171:6372-6374(1989).
CC -!- FUNCTION: Fimbriae (also called pili), polar filaments radiating from
CC the surface of the bacterium to a length of 0.5-1.5 micrometers and
CC numbering 100-300 per cell, enable bacteria to colonize the epithelium
CC of specific host organs.
CC -!- SUBUNIT: CFA/I fimbriae are rather rigid, thread-like filaments of 0.5-
CC 1 micrometer, with an apparent axial hole, and a diameter of 7
CC nanometers. A single CFA/I fimbria consists of about 100 identical
CC protein subunits.
CC -!- SUBCELLULAR LOCATION: Fimbrium.
CC -!- INDUCTION: CFA/I fimbriae are only expressed in the presence of the
CC positive regulator CfaD.
CC -!- SIMILARITY: Belongs to the fimbrial CS1 protein family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FN649418; CBJ04487.1; -; Genomic_DNA.
DR PIR; A30589; YQECC1.
DR RefSeq; WP_000669510.1; NC_017724.1.
DR PDB; 3F83; X-ray; 2.30 A; A=24-170.
DR PDB; 3F84; X-ray; 2.35 A; A/B=24-170.
DR PDB; 3F85; X-ray; 2.10 A; A=24-170.
DR PDB; 4Y2L; X-ray; 1.75 A; A/B/C/D/E/F=25-170.
DR PDB; 4Y2N; X-ray; 2.40 A; A/B/C=25-170.
DR PDB; 4Y2O; X-ray; 2.42 A; B=37-170.
DR PDBsum; 3F83; -.
DR PDBsum; 3F84; -.
DR PDBsum; 3F85; -.
DR PDBsum; 4Y2L; -.
DR PDBsum; 4Y2N; -.
DR PDBsum; 4Y2O; -.
DR AlphaFoldDB; E3PPC4; -.
DR SMR; E3PPC4; -.
DR EnsemblBacteria; CBJ04487; CBJ04487; ETEC_p948_0400.
DR KEGG; elh:ETEC_p948_0400; -.
DR HOGENOM; CLU_129877_0_0_6; -.
DR OMA; HTNDATK; -.
DR EvolutionaryTrace; E3PPC4; -.
DR Proteomes; UP000006877; Plasmid p948.
DR GO; GO:0009289; C:pilus; IEA:UniProtKB-SubCell.
DR InterPro; IPR007540; Fimbrial_CS1-type.
DR Pfam; PF04449; Fimbrial_CS1; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Direct protein sequencing; Fimbrium; Plasmid; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000269|PubMed:2572583"
FT CHAIN 24..170
FT /note="CFA/I fimbrial subunit B"
FT /id="PRO_0000405303"
FT CONFLICT 76
FT /note="D -> N (in Ref. 3; no nucleotide entry)"
FT /evidence="ECO:0000305"
FT CONFLICT 97
FT /note="S -> A (in Ref. 3; no nucleotide entry)"
FT /evidence="ECO:0000305"
FT STRAND 25..34
FT /evidence="ECO:0007829|PDB:4Y2L"
FT STRAND 36..42
FT /evidence="ECO:0007829|PDB:4Y2L"
FT STRAND 50..53
FT /evidence="ECO:0007829|PDB:4Y2L"
FT TURN 58..61
FT /evidence="ECO:0007829|PDB:4Y2L"
FT STRAND 66..75
FT /evidence="ECO:0007829|PDB:4Y2L"
FT TURN 76..79
FT /evidence="ECO:0007829|PDB:4Y2O"
FT STRAND 81..87
FT /evidence="ECO:0007829|PDB:4Y2L"
FT STRAND 90..93
FT /evidence="ECO:0007829|PDB:4Y2L"
FT STRAND 96..107
FT /evidence="ECO:0007829|PDB:4Y2L"
FT STRAND 117..119
FT /evidence="ECO:0007829|PDB:4Y2L"
FT TURN 121..125
FT /evidence="ECO:0007829|PDB:4Y2L"
FT HELIX 126..129
FT /evidence="ECO:0007829|PDB:4Y2L"
FT STRAND 138..144
FT /evidence="ECO:0007829|PDB:4Y2L"
FT STRAND 147..150
FT /evidence="ECO:0007829|PDB:4Y2O"
FT STRAND 155..168
FT /evidence="ECO:0007829|PDB:4Y2L"
SQ SEQUENCE 170 AA; 17461 MW; 924347F07F33CDAB CRC64;
MKFKKTIGAM ALTTMFVAVS ASAVEKNITV TASVDPVIDL LQADGNALPS AVKLAYSPAS
KTFESYRVMT QVHTNDATKK VIVKLADTPQ LTDVLNSTVQ MPISVSWGGQ VLSTTAKEFE
AAALGYSASG VNGVSSSQEL VISAAPKTAG TAPTAGNYSG VVSLVMTLGS
