ID   FMC1_ECOLX              Reviewed;         170 AA.
AC   P0CK93; P02971;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   08-MAR-2011, sequence version 1.
DT   25-MAY-2022, entry version 16.
DE   RecName: Full=CFA/I fimbrial subunit B;
DE   AltName: Full=CFA/I antigen;
DE   AltName: Full=CFA/I pilin;
DE   AltName: Full=Colonization factor antigen I subunit B;
DE   Flags: Precursor;
GN   Name=cfaB;
OS   Escherichia coli.
OG   Plasmid NTP513.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=O78:H12 / E7473 / ETEC;
RX   PubMed=2569152; DOI=10.1016/0882-4010(89)90103-4;
RA   Hamers A.M., Pel H.J., Willshaw G.A., Kusters J.G., van der Zeijst B.A.M.,
RA   Gaastra W.;
RT   "The nucleotide sequence of the first two genes of the CFA/I fimbrial
RT   operon of human enterotoxigenic Escherichia coli.";
RL   Microb. Pathog. 6:297-309(1989).
CC   -!- FUNCTION: Fimbriae (also called pili), polar filaments radiating from
CC       the surface of the bacterium to a length of 0.5-1.5 micrometers and
CC       numbering 100-300 per cell, enable bacteria to colonize the epithelium
CC       of specific host organs.
CC   -!- SUBUNIT: CFA/I fimbriae are rather rigid, thread-like filaments of 0.5-
CC       1 micrometer, with an apparent axial hole, and a diameter of 7
CC       nanometers. A single CFA/I fimbria consists of about 100 identical
CC       protein subunits.
CC   -!- SUBCELLULAR LOCATION: Fimbrium.
CC   -!- INDUCTION: CFA/I fimbriae are only expressed in the presence of the
CC       positive regulator CfaD.
CC   -!- SIMILARITY: Belongs to the fimbrial CS1 protein family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M55661; AAC41415.1; -; Genomic_DNA.
DR   RefSeq; WP_000669509.1; NZ_UEMW01000053.1.
DR   PDB; 6NRV; EM; 4.00 A; A/B/C/D/E/F/G/H/I/J/K/L/M=24-169.
DR   PDBsum; 6NRV; -.
DR   AlphaFoldDB; P0CK93; -.
DR   SMR; P0CK93; -.
DR   GO; GO:0009289; C:pilus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR007540; Fimbrial_CS1-type.
DR   Pfam; PF04449; Fimbrial_CS1; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Fimbrium; Plasmid; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000250"
FT   CHAIN           24..170
FT                   /note="CFA/I fimbrial subunit B"
FT                   /id="PRO_0000009179"
SQ   SEQUENCE   170 AA;  17433 MW;  894347E2F43E56B4 CRC64;
     MKFKKTIGAM ALTTMFVAVS ASAVEKNITV TASVDPAIDL LQADGNALPS AVKLAYSPAS
     KTFESYRVMT QVHTNDATKK VIVKLADTPQ LTDVLNSTVQ MPISVSWGGQ VLSTTAKEFE
     AAALGYSASG VNGVSSSQEL VISAAPKTAG TAPTAGNYSG VVSLVMTLGS