FMC1_YEAST
ID FMC1_YEAST Reviewed; 155 AA.
AC P40491; D6VVI9;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=ATP synthase assembly factor FMC1, mitochondrial;
DE AltName: Full=Formation of mitochondrial complexes protein 1;
DE Flags: Precursor;
GN Name=FMC1; OrderedLocusNames=YIL098C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169870;
RA Churcher C.M., Bowman S., Badcock K., Bankier A.T., Brown D.,
RA Chillingworth T., Connor R., Devlin K., Gentles S., Hamlin N., Harris D.E.,
RA Horsnell T., Hunt S., Jagels K., Jones M., Lye G., Moule S., Odell C.,
RA Pearson D., Rajandream M.A., Rice P., Rowley N., Skelton J., Smith V.,
RA Walsh S.V., Whitehead S., Barrell B.G.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome IX.";
RL Nature 387:84-87(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [4]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=11096112; DOI=10.1074/jbc.m009557200;
RA Lefebvre-Legendre L., Vaillier J., Benabdelhak H., Velours J.,
RA Slonimski P.P., di Rago J.-P.;
RT "Identification of a nuclear gene (FMC1) required for the
RT assembly/stability of yeast mitochondrial F(1)-ATPase in heat stress
RT conditions.";
RL J. Biol. Chem. 276:6789-6796(2001).
RN [5]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [6]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 76625 / YPH499;
RX PubMed=14576278; DOI=10.1073/pnas.2135385100;
RA Sickmann A., Reinders J., Wagner Y., Joppich C., Zahedi R.P., Meyer H.E.,
RA Schoenfisch B., Perschil I., Chacinska A., Guiard B., Rehling P.,
RA Pfanner N., Meisinger C.;
RT "The proteome of Saccharomyces cerevisiae mitochondria.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:13207-13212(2003).
RN [7]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
CC -!- FUNCTION: Needed for the assembly of the mitochondrial F1-F0 complex at
CC high temperature. {ECO:0000269|PubMed:11096112}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:11096112,
CC ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:14576278}.
CC -!- MISCELLANEOUS: Present with 589 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the FMC1 family. {ECO:0000305}.
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DR EMBL; Z38125; CAA86283.1; -; Genomic_DNA.
DR EMBL; AY558072; AAS56398.1; -; Genomic_DNA.
DR EMBL; BK006942; DAA08455.1; -; Genomic_DNA.
DR PIR; S48475; S48475.
DR RefSeq; NP_012168.3; NM_001179446.3.
DR AlphaFoldDB; P40491; -.
DR SMR; P40491; -.
DR BioGRID; 34893; 354.
DR DIP; DIP-5652N; -.
DR IntAct; P40491; 1.
DR MINT; P40491; -.
DR STRING; 4932.YIL098C; -.
DR MaxQB; P40491; -.
DR PaxDb; P40491; -.
DR PRIDE; P40491; -.
DR EnsemblFungi; YIL098C_mRNA; YIL098C; YIL098C.
DR GeneID; 854709; -.
DR KEGG; sce:YIL098C; -.
DR SGD; S000001360; FMC1.
DR VEuPathDB; FungiDB:YIL098C; -.
DR eggNOG; ENOG502SD6J; Eukaryota.
DR HOGENOM; CLU_128881_1_0_1; -.
DR InParanoid; P40491; -.
DR OMA; NQREYFE; -.
DR BioCyc; YEAST:G3O-31357-MON; -.
DR PRO; PR:P40491; -.
DR Proteomes; UP000002311; Chromosome IX.
DR RNAct; P40491; protein.
DR GO; GO:0005759; C:mitochondrial matrix; IDA:SGD.
DR GO; GO:0005739; C:mitochondrion; HDA:SGD.
DR GO; GO:0016236; P:macroautophagy; IMP:SGD.
DR GO; GO:0033615; P:mitochondrial proton-transporting ATP synthase complex assembly; IMP:SGD.
DR InterPro; IPR039196; Fmc1.
DR PANTHER; PTHR28015; PTHR28015; 1.
PE 1: Evidence at protein level;
KW Mitochondrion; Reference proteome; Stress response; Transit peptide.
FT TRANSIT 1..?
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN ?..155
FT /note="ATP synthase assembly factor FMC1, mitochondrial"
FT /id="PRO_0000202969"
SQ SEQUENCE 155 AA; 18364 MW; EAE988BFACA1F330 CRC64;
MDRPRTLRTY RGLIRAILKY ERPSKIVNWG NLRKAMITKL EYAKKQNQRD SHENINRQLE
KWKKLDPVSD RSLNLFIADS KSLRSILQND IKWEKKVAQG QNVDEIFEHA LDIIKFLDNQ
REYEELVDRY NPGNKLTQDE KVKRTANVVG LDVPT
