ID   FMDA_SCHPO              Reviewed;         410 AA.
AC   Q9URY7;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Putative formamidase C869.04;
DE            EC=3.5.1.49;
DE   AltName: Full=Formamide amidohydrolase;
GN   ORFNames=SPAC869.04;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- FUNCTION: Hydrolyzes formamide with the production of ammonia which can
CC       be used as a source of nitrogen for growth. May also act on acetamide,
CC       propanamide and butanamide (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=formamide + H2O = formate + NH4(+); Xref=Rhea:RHEA:21948,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15740, ChEBI:CHEBI:16397,
CC         ChEBI:CHEBI:28938; EC=3.5.1.49;
CC   -!- SUBUNIT: Homotrimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus
CC       {ECO:0000269|PubMed:16823372}.
CC   -!- SIMILARITY: Belongs to the acetamidase/formamidase family.
CC       {ECO:0000305}.
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DR   EMBL; CU329670; CAB60014.1; -; Genomic_DNA.
DR   PIR; T39115; T39115.
DR   RefSeq; NP_595015.1; NM_001020446.1.
DR   AlphaFoldDB; Q9URY7; -.
DR   SMR; Q9URY7; -.
DR   BioGRID; 279569; 5.
DR   STRING; 4896.SPAC869.04.1; -.
DR   PaxDb; Q9URY7; -.
DR   EnsemblFungi; SPAC869.04.1; SPAC869.04.1:pep; SPAC869.04.
DR   GeneID; 2543137; -.
DR   KEGG; spo:SPAC869.04; -.
DR   PomBase; SPAC869.04; -.
DR   VEuPathDB; FungiDB:SPAC869.04; -.
DR   eggNOG; ENOG502QRMK; Eukaryota.
DR   HOGENOM; CLU_032013_0_1_1; -.
DR   InParanoid; Q9URY7; -.
DR   OMA; PWGFTGI; -.
DR   PhylomeDB; Q9URY7; -.
DR   PRO; PR:Q9URY7; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0004328; F:formamidase activity; IEA:UniProtKB-EC.
DR   InterPro; IPR004304; FmdA_AmdA.
DR   PANTHER; PTHR31891; PTHR31891; 1.
DR   Pfam; PF03069; FmdA_AmdA; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Hydrolase; Nucleus; Reference proteome.
FT   CHAIN           1..410
FT                   /note="Putative formamidase C869.04"
FT                   /id="PRO_0000316040"
SQ   SEQUENCE   410 AA;  44793 MW;  D42F7A0222920D36 CRC64;
     MAPRTIVKVD LNKPAWEQPN LHNRWHPDIP FAESIDEGET VKIECLDWTG GQIKNDDSAE
     DIKNVDLTRI HYLSGPFEIK GAEPGDVLVV EIQDVQPLEN QPWGYSGIFA KENGGGFLDE
     HYPKAAKAVF DFEGIFCSSR HIPGVRFPGL IHPGIIGTAP SKEILAEWNR REGALVAENP
     HSTHVMAQLP NASYAFAGIL ADEKLSATVA SEGARTIPGR PENGGNCDIK NLSRGSKVFL
     PVHVPGAKLS IGDLHFSQGD GEISFCGAIE MAGSITIKCK ILKNGISDLA MKSPMYLPGP
     VEPHFSPSRY LTFEGFSVDE SGKQHYLCTT TAYRQTCLRV IEYFRRFGYN DYQLYLLLSC
     APIQGHVAGI VDIPNSCTTI GVPMDIFEFD VSPNGKAKII DLGSCAFANS