ID   FMO1_CAVPO              Reviewed;          19 AA.
AC   P49328;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Dimethylaniline monooxygenase [N-oxide-forming] 1;
DE            EC=1.14.13.8;
DE   AltName: Full=Dimethylaniline oxidase 1;
DE   AltName: Full=Hepatic flavin-containing monooxygenase 1;
DE            Short=FMO 1;
DE   Flags: Fragment;
GN   Name=FMO1; Synonyms=FMO-1;
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC   Cavia.
OX   NCBI_TaxID=10141;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Liver;
RX   PubMed=2369122; DOI=10.1016/0003-9861(90)90334-u;
RA   Yamada H., Yuno K., Oguri K., Yoshimura H.;
RT   "Multiplicity of liver microsomal flavin-containing monooxygenase in the
RT   guinea pig: its purification and characterization.";
RL   Arch. Biochem. Biophys. 280:305-312(1990).
CC   -!- FUNCTION: This protein is involved in the oxidative metabolism of a
CC       variety of xenobiotics such as drugs and pesticides.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + N,N-dimethylaniline + NADPH + O2 = H2O + N,N-
CC         dimethylaniline N-oxide + NADP(+); Xref=Rhea:RHEA:24468,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379,
CC         ChEBI:CHEBI:16269, ChEBI:CHEBI:17735, ChEBI:CHEBI:57783,
CC         ChEBI:CHEBI:58349; EC=1.14.13.8;
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC   -!- SUBCELLULAR LOCATION: Microsome membrane
CC       {ECO:0000250|UniProtKB:Q95LA2}; Single-pass membrane protein
CC       {ECO:0000255}. Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q95LA2}; Single-pass membrane protein
CC       {ECO:0000255}.
CC   -!- TISSUE SPECIFICITY: Liver.
CC   -!- SIMILARITY: Belongs to the FMO family. {ECO:0000305}.
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DR   PIR; S10747; S10747.
DR   AlphaFoldDB; P49328; -.
DR   eggNOG; KOG1399; Eukaryota.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   GO; GO:0004499; F:N,N-dimethylaniline monooxygenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   InterPro; IPR020946; Flavin_mOase-like.
DR   Pfam; PF00743; FMO-like; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Endoplasmic reticulum; FAD; Flavoprotein;
KW   Membrane; Microsome; Monooxygenase; NADP; Oxidoreductase;
KW   Reference proteome; Transmembrane.
FT   CHAIN           1..>19
FT                   /note="Dimethylaniline monooxygenase [N-oxide-forming] 1"
FT                   /id="PRO_0000147638"
FT   BINDING         8..12
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000250|UniProtKB:Q9HFE4"
FT   NON_TER         19
SQ   SEQUENCE   19 AA;  1826 MW;  324DDEB75CA05522 CRC64;
     VKKVAIIGAG VSGLASIRS