FMOD_PIG
ID FMOD_PIG Reviewed; 147 AA.
AC Q9TTB4;
DT 20-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 104.
DE RecName: Full=Fibromodulin;
DE Short=FM;
DE AltName: Full=Keratan sulfate proteoglycan lumican;
DE Short=KSPG fibromodulin;
DE Flags: Fragment;
GN Name=FMOD;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Skin;
RA Wang J.F., Boykiw R.H., Reno C.R., Olson M.E., Hart D.A.;
RT "Cloning and sequencing of porcine matrix molecules.";
RL Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Affects the rate of fibrils formation. May have a primary
CC role in collagen fibrillogenesis (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Binds to type I and type II collagen. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix.
CC -!- PTM: Binds keratan sulfate chains. {ECO:0000250}.
CC -!- MISCELLANEOUS: Incorrect gene name (LUM) has been attributed by Ref.1.
CC LUM and FMOD are two different genes but members of the same family.
CC -!- SIMILARITY: Belongs to the small leucine-rich proteoglycan (SLRP)
CC family. SLRP class II subfamily. {ECO:0000305}.
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DR EMBL; AF159383; AAF19154.1; -; mRNA.
DR AlphaFoldDB; Q9TTB4; -.
DR SMR; Q9TTB4; -.
DR STRING; 9823.ENSSSCP00000016193; -.
DR PaxDb; Q9TTB4; -.
DR PeptideAtlas; Q9TTB4; -.
DR eggNOG; KOG0619; Eukaryota.
DR HOGENOM; CLU_000288_186_4_1; -.
DR InParanoid; Q9TTB4; -.
DR Proteomes; UP000008227; Unplaced.
DR Proteomes; UP000314985; Unplaced.
DR Genevisible; Q9TTB4; SS.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; IEA:InterPro.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR027215; Fibromodulin.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR45712:SF4; PTHR45712:SF4; 1.
DR Pfam; PF13855; LRR_8; 2.
DR SMART; SM00369; LRR_TYP; 4.
DR PROSITE; PS51450; LRR; 6.
PE 2: Evidence at transcript level;
KW Extracellular matrix; Glycoprotein; Leucine-rich repeat; Proteoglycan;
KW Reference proteome; Repeat; Secreted; Sulfation.
FT CHAIN <1..>147
FT /note="Fibromodulin"
FT /id="PRO_0000180084"
FT REPEAT <1..15
FT /note="LRR 1"
FT REPEAT 16..37
FT /note="LRR 2"
FT REPEAT 40..61
FT /note="LRR 3"
FT REPEAT 63..84
FT /note="LRR 4"
FT REPEAT 85..105
FT /note="LRR 5"
FT REPEAT 108..128
FT /note="LRR 6"
FT REPEAT 133..>147
FT /note="LRR 7"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) (keratan sulfate) asparagine"
FT /evidence="ECO:0000250"
FT CARBOHYD 40
FT /note="N-linked (GlcNAc...) (keratan sulfate) asparagine"
FT /evidence="ECO:0000250"
FT CARBOHYD 130
FT /note="N-linked (GlcNAc...) (keratan sulfate) asparagine"
FT /evidence="ECO:0000250"
FT NON_TER 1
FT NON_TER 147
SQ SEQUENCE 147 AA; 16686 MW; 652B5231CAE27EF6 CRC64;
LDHNNLTRMP GPLPRSLREL HLDHNQISRV PNNALEGLEN LTALYLQHNE IQEVGSSMRG
LRSLILLDLS YNHLRKVPDG LPSALEQLYL EHNNVYSVPD SYFRGSPKLL YVRLSHNSLT
NNGLASNTFN SSSLLELDLS YNQLQKI