FMP23_YEAST
ID FMP23_YEAST Reviewed; 175 AA.
AC P38231; D6VQ47;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1994, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Protein FMP23, mitochondrial;
DE Flags: Precursor;
GN Name=FMP23; OrderedLocusNames=YBR047W; ORFNames=YBR0422;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=7813418; DOI=10.1002/j.1460-2075.1994.tb06923.x;
RA Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C.,
RA Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M.,
RA Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M.,
RA Cziepluch C., Demolis N., Delaveau T., Doignon F., Domdey H.,
RA Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D.,
RA Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N.,
RA Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J.,
RA Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C.,
RA Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P.,
RA Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y.,
RA Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F.,
RA Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E.,
RA Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M.,
RA Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B.,
RA Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L.,
RA Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M.,
RA Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S.,
RA Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K.,
RA Mewes H.-W., Kleine K.;
RT "Complete DNA sequence of yeast chromosome II.";
RL EMBO J. 13:5795-5809(1994).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [4]
RP INDUCTION.
RX PubMed=10601195; DOI=10.1128/jb.181.24.7409-7413.1999;
RA ter Linde J.J.M., Liang H., Davis R.W., Steensma H.Y., van Dijken J.P.,
RA Pronk J.T.;
RT "Genome-wide transcriptional analysis of aerobic and anaerobic chemostat
RT cultures of Saccharomyces cerevisiae.";
RL J. Bacteriol. 181:7409-7413(1999).
RN [5]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [6]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [7]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 76625 / YPH499;
RX PubMed=14576278; DOI=10.1073/pnas.2135385100;
RA Sickmann A., Reinders J., Wagner Y., Joppich C., Zahedi R.P., Meyer H.E.,
RA Schoenfisch B., Perschil I., Chacinska A., Guiard B., Rehling P.,
RA Pfanner N., Meisinger C.;
RT "The proteome of Saccharomyces cerevisiae mitochondria.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:13207-13212(2003).
RN [8]
RP INDUCTION, AND PROBABLE FUNCTION.
RX PubMed=14534306; DOI=10.1074/jbc.m212308200;
RA De Freitas J.M., Kim J.H., Poynton H., Su T., Wintz H., Fox T., Holman P.,
RA Loguinov A., Keles S., van der Laan M., Vulpe C.;
RT "Exploratory and confirmatory gene expression profiling of mac1Delta.";
RL J. Biol. Chem. 279:4450-4458(2004).
RN [9]
RP INDUCTION.
RX PubMed=15886332; DOI=10.1152/physiolgenomics.00055.2005;
RA van Bakel H., Strengman E., Wijmenga C., Holstege F.C.P.;
RT "Gene expression profiling and phenotype analyses of S. cerevisiae in
RT response to changing copper reveals six genes with new roles in copper and
RT iron metabolism.";
RL Physiol. Genomics 22:356-367(2005).
CC -!- FUNCTION: May be involved in mitochondrial iron or copper homeostatis.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305}.
CC -!- INDUCTION: In aerobic conditions. Expression is regulated by copper
CC levels and the MAC1 copper-responsive transcription factor.
CC {ECO:0000269|PubMed:10601195, ECO:0000269|PubMed:14534306,
CC ECO:0000269|PubMed:15886332}.
CC -!- MISCELLANEOUS: Present with 2160 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
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DR EMBL; Z35916; CAA84989.1; -; Genomic_DNA.
DR EMBL; AY557704; AAS56030.1; -; Genomic_DNA.
DR EMBL; BK006936; DAA07167.1; -; Genomic_DNA.
DR PIR; S45905; S45905.
DR RefSeq; NP_009603.1; NM_001178395.1.
DR AlphaFoldDB; P38231; -.
DR BioGRID; 32749; 90.
DR DIP; DIP-5297N; -.
DR MINT; P38231; -.
DR STRING; 4932.YBR047W; -.
DR PaxDb; P38231; -.
DR PRIDE; P38231; -.
DR EnsemblFungi; YBR047W_mRNA; YBR047W; YBR047W.
DR GeneID; 852336; -.
DR KEGG; sce:YBR047W; -.
DR SGD; S000000251; FMP23.
DR VEuPathDB; FungiDB:YBR047W; -.
DR eggNOG; ENOG502S3B9; Eukaryota.
DR HOGENOM; CLU_1483131_0_0_1; -.
DR InParanoid; P38231; -.
DR OMA; GGHTFIF; -.
DR BioCyc; YEAST:G3O-29019-MON; -.
DR PRO; PR:P38231; -.
DR Proteomes; UP000002311; Chromosome II.
DR RNAct; P38231; protein.
DR GO; GO:0005739; C:mitochondrion; HDA:SGD.
DR InterPro; IPR035283; Fmp23.
DR Pfam; PF17315; FMP23; 1.
PE 1: Evidence at protein level;
KW Mitochondrion; Reference proteome; Transit peptide.
FT TRANSIT 1..38
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 39..175
FT /note="Protein FMP23, mitochondrial"
FT /id="PRO_0000202474"
SQ SEQUENCE 175 AA; 20513 MW; 8688C7763DC13A4F CRC64;
MLINHLSKIR TVRHFSNIKP VLSKEVSRRV IVAPASHFKT SSPNVKSNIP IHEYKQLPED
SNYIEKHYKE LQVFLNEFLI KKLNKTYADF EGDPDELVFQ LEKFIELEVT PRYTNHSAPD
GCEERFKSIG DRIVVDRYLD FVKDVRLTLL LNGGHSFIFD VMLQAKEVFD KMQKE
