FMP25_YEAST
ID FMP25_YEAST Reviewed; 583 AA.
AC Q08023; D6VY77; Q66R51; Q7LI62;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Protein FMP25, mitochondrial;
DE AltName: Full=Found in mitochondrial proteome protein 25;
DE Flags: Precursor;
GN Name=FMP25; OrderedLocusNames=YLR077W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169871;
RA Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W.,
RA Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A.,
RA Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K.,
RA Heuss-Neitzel D., Hilbert H., Hilger F., Kleine K., Koetter P., Louis E.J.,
RA Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S.,
RA Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D.,
RA Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M.,
RA Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P.,
RA Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M.,
RA Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K.,
RA Zollner A., Hani J., Hoheisel J.D.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.";
RL Nature 387:87-90(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [4]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 76625 / YPH499;
RX PubMed=14576278; DOI=10.1073/pnas.2135385100;
RA Sickmann A., Reinders J., Wagner Y., Joppich C., Zahedi R.P., Meyer H.E.,
RA Schoenfisch B., Perschil I., Chacinska A., Guiard B., Rehling P.,
RA Pfanner N., Meisinger C.;
RT "The proteome of Saccharomyces cerevisiae mitochondria.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:13207-13212(2003).
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000305}; Single-pass
CC membrane protein {ECO:0000305}.
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DR EMBL; Z73249; CAA97635.1; -; Genomic_DNA.
DR EMBL; Z73250; CAA97637.1; -; Genomic_DNA.
DR EMBL; U53880; AAB67597.1; -; Genomic_DNA.
DR EMBL; AY723844; AAU09761.1; -; Genomic_DNA.
DR EMBL; BK006945; DAA09393.1; -; Genomic_DNA.
DR PIR; S64909; S64909.
DR RefSeq; NP_013178.1; NM_001181964.1.
DR AlphaFoldDB; Q08023; -.
DR SMR; Q08023; -.
DR BioGRID; 31350; 62.
DR DIP; DIP-4474N; -.
DR IntAct; Q08023; 3.
DR MINT; Q08023; -.
DR STRING; 4932.YLR077W; -.
DR MaxQB; Q08023; -.
DR PaxDb; Q08023; -.
DR PRIDE; Q08023; -.
DR EnsemblFungi; YLR077W_mRNA; YLR077W; YLR077W.
DR GeneID; 850766; -.
DR KEGG; sce:YLR077W; -.
DR SGD; S000004067; FMP25.
DR VEuPathDB; FungiDB:YLR077W; -.
DR eggNOG; KOG1426; Eukaryota.
DR GeneTree; ENSGT00940000174956; -.
DR HOGENOM; CLU_028610_1_0_1; -.
DR InParanoid; Q08023; -.
DR OMA; LFWGGNE; -.
DR BioCyc; YEAST:G3O-32228-MON; -.
DR PRO; PR:Q08023; -.
DR Proteomes; UP000002311; Chromosome XII.
DR RNAct; Q08023; protein.
DR GO; GO:0031305; C:integral component of mitochondrial inner membrane; IDA:SGD.
DR GO; GO:0005739; C:mitochondrion; HDA:SGD.
DR GO; GO:0034551; P:mitochondrial respiratory chain complex III assembly; IMP:SGD.
DR Gene3D; 2.130.10.30; -; 1.
DR InterPro; IPR009091; RCC1/BLIP-II.
DR InterPro; IPR000408; Reg_chr_condens.
DR Pfam; PF00415; RCC1; 1.
DR SUPFAM; SSF50985; SSF50985; 1.
DR PROSITE; PS00626; RCC1_2; 1.
PE 4: Predicted;
KW Membrane; Mitochondrion; Reference proteome; Repeat; Transit peptide;
KW Transmembrane; Transmembrane helix.
FT TRANSIT 1..25
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 26..583
FT /note="Protein FMP25, mitochondrial"
FT /id="PRO_0000247338"
FT TRANSMEM 83..105
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REPEAT 332..389
FT /note="RCC1 1"
FT REPEAT 390..452
FT /note="RCC1 2"
FT REPEAT 459..510
FT /note="RCC1 3"
FT REPEAT 512..569
FT /note="RCC1 4"
FT CONFLICT 160
FT /note="P -> L (in Ref. 3; AAU09761)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 583 AA; 66690 MW; B2EE61451F2A9948 CRC64;
MSFRLFTRTS QRLPRLNWVS PIRRYAKQPQ YDEAELFAEN INHGAYKAKK RPSDEHFQWP
EKSPDQITKE SELQWERMAK LSAVGQGILI LVVVGGLGTA YLRWPELKSW WLIKMNGGRI
NATQEQSGQD SLEKLIRQKA KNLLREIPQV PAFQLGIDHP GVYIWGRCHS KDSLFPVRVP
NLDGRKFRDI LLAPSDDFNT NFAIDEKGDL ISWDDLGQTK TILPDQDLTS MKYSSHFLYA
LNKKGEILVI PIRTPDLIAS QVSSRRSKLL PWKTKLRYDW KLQTNQIFNG KEGEKRVVQF
DAGSHHLVLL SNLGKAYCCA TGNDQKQAQV SKGQFGIPTF SQFDEFPPNN QLFEIELLNK
FKHEGEDVVR KREIKKIACG SYHTLAIDKT GEIYAFGWNR FGQLALPISY NLEYVSFPRS
VTHAFKPHFP GMTNWKCVDI HCDDETSFVT IRKPGSTSDH HYFAFGNGLF GELGNNTFKN
SQCDPIKIKS DDKKLTNWSC GSHCVFTETE QENEVIAWGN NDHGQLGIGK KTMKCAKPMN
IPEVLKPGQD TTDLDSIYNS KLHLKKEQRV VTNGNKSCLY WRV
