FMP27_YEAST
ID FMP27_YEAST Reviewed; 2628 AA.
AC Q06179; D6VZ88;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Protein FMP27, mitochondrial;
DE AltName: Full=Found in mitochondrial proteome protein 27;
DE Flags: Precursor;
GN Name=FMP27; OrderedLocusNames=YLR454W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169871;
RA Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W.,
RA Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A.,
RA Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K.,
RA Heuss-Neitzel D., Hilbert H., Hilger F., Kleine K., Koetter P., Louis E.J.,
RA Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S.,
RA Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D.,
RA Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M.,
RA Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P.,
RA Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M.,
RA Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K.,
RA Zollner A., Hani J., Hoheisel J.D.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.";
RL Nature 387:87-90(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [4]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 76625 / YPH499;
RX PubMed=14576278; DOI=10.1073/pnas.2135385100;
RA Sickmann A., Reinders J., Wagner Y., Joppich C., Zahedi R.P., Meyer H.E.,
RA Schoenfisch B., Perschil I., Chacinska A., Guiard B., Rehling P.,
RA Pfanner N., Meisinger C.;
RT "The proteome of Saccharomyces cerevisiae mitochondria.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:13207-13212(2003).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=ADR376;
RX PubMed=17330950; DOI=10.1021/pr060559j;
RA Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,
RA Elias J.E., Gygi S.P.;
RT "Large-scale phosphorylation analysis of alpha-factor-arrested
RT Saccharomyces cerevisiae.";
RL J. Proteome Res. 6:1190-1197(2007).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=18407956; DOI=10.1074/mcp.m700468-mcp200;
RA Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
RT "A multidimensional chromatography technology for in-depth phosphoproteome
RT analysis.";
RL Mol. Cell. Proteomics 7:1389-1396(2008).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19779198; DOI=10.1126/science.1172867;
RA Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.;
RT "Global analysis of Cdk1 substrate phosphorylation sites provides insights
RT into evolution.";
RL Science 325:1682-1686(2009).
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:14576278}.
CC -!- MISCELLANEOUS: Present with 1360 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
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DR EMBL; U22383; AAB64718.1; -; Genomic_DNA.
DR EMBL; BK006945; DAA09754.1; -; Genomic_DNA.
DR PIR; S59413; S59413.
DR RefSeq; NP_013559.1; NM_001182342.1.
DR AlphaFoldDB; Q06179; -.
DR SMR; Q06179; -.
DR BioGRID; 31712; 64.
DR DIP; DIP-3005N; -.
DR IntAct; Q06179; 6.
DR MINT; Q06179; -.
DR STRING; 4932.YLR454W; -.
DR iPTMnet; Q06179; -.
DR MaxQB; Q06179; -.
DR PaxDb; Q06179; -.
DR PRIDE; Q06179; -.
DR TopDownProteomics; Q06179; -.
DR EnsemblFungi; YLR454W_mRNA; YLR454W; YLR454W.
DR GeneID; 851175; -.
DR KEGG; sce:YLR454W; -.
DR SGD; S000004446; FMP27.
DR VEuPathDB; FungiDB:YLR454W; -.
DR eggNOG; KOG1910; Eukaryota.
DR GeneTree; ENSGT00600000084481; -.
DR HOGENOM; CLU_000740_0_0_1; -.
DR InParanoid; Q06179; -.
DR OMA; MIFQIGL; -.
DR BioCyc; YEAST:G3O-32507-MON; -.
DR PRO; PR:Q06179; -.
DR Proteomes; UP000002311; Chromosome XII.
DR RNAct; Q06179; protein.
DR GO; GO:0005739; C:mitochondrion; HDA:SGD.
DR InterPro; IPR045167; FMP27.
DR InterPro; IPR019443; FMP27_C.
DR InterPro; IPR019409; FMP27_DUF2405.
DR InterPro; IPR019441; FMP27_GFWDK_dom.
DR InterPro; IPR019439; FMP27_N.
DR InterPro; IPR019415; FMP27_SW_dom.
DR InterPro; IPR019449; FMP27_WPPW_dom.
DR PANTHER; PTHR15678; PTHR15678; 1.
DR Pfam; PF10351; Apt1; 2.
DR Pfam; PF10293; DUF2405; 1.
DR Pfam; PF10344; Fmp27; 1.
DR Pfam; PF10347; Fmp27_GFWDK; 1.
DR Pfam; PF10305; Fmp27_SW; 1.
DR Pfam; PF10359; Fmp27_WPPW; 1.
DR SMART; SM01214; Fmp27_GFWDK; 1.
DR SMART; SM01215; Fmp27_SW; 1.
DR SMART; SM01216; Fmp27_WPPW; 1.
PE 1: Evidence at protein level;
KW Mitochondrion; Reference proteome; Transit peptide.
FT TRANSIT 1..?
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN ?..2628
FT /note="Protein FMP27, mitochondrial"
FT /id="PRO_0000247777"
SQ SEQUENCE 2628 AA; 303479 MW; 82B0F6296B59E34E CRC64;
MMFPINVLLY KWLIFAVTFL WSCKILLRKL LGINITWINL FKLEICGLSL EDGTVRLKSV
RFAVFERKLF IKGLRIDSKK SSTNDLHKEL PREEERTFIE TPEDNGGGFI SKILSLSQYW
LNGVTIILED TQLVNNDITI EKFGFFLSID NSKHIKSLRF DSFLRKLLWN GQTIIADAIF
IVNTNLLIGE IMNPLKDGLQ VGLDLKLGDL NIPMNLLNLF INKENVDLMS NEKLLQRLAD
TTKANEELKD EDIAKMKDDL VYAMEKFVDR IKPLKEMNVT VDKLQIKDFP LTNHPELLGM
NKYISYNVLV SNINFNTNRF RNEMPGYTLI FEERDSPFKF SIIMARFNIY LNLNRKHQSH
AKQLKIIEIP NVSIFGETNL FSQKFRLSNN LHAKELENAI FNIKGNISSL TIDMDPVNIS
FIKCFLSNIK VFTSSCPKNK ILKENSHVKF LTRRRVLFDY FKCFLPLINM KFTLDDPKFV
INDKDDLIIG KFSVFMISHH SKRYTLGNNL MEEKEETQHI FYESHWNVEL LDMKLQHIIK
HQKYEHTILR VDSIAIEEKV QLLPDILCSA NADIDTLMLD LSELPTMVML SELVHNLDSQ
LANVEENYFK EFYEKFASNL QNMKAECSNM AKCLRQKEIL PSDFMFQQLP DFFDYIKINI
RDISSTLGAR SVFMPRDVFS SVDSQSSKDL IDGKLRKYCN TVEKLQIALF GDKTQWHNKI
GSNHATMVRS GQLTNFSKDN KQNPNHKSSI ADLDDISTSD ATEVNHLWNI NLLVNDITTS
IIGETPEVSE ELSTKTVSKV SNLSIKLFPD TESFSSNESD SKIILQINHS RGTSVVSLMS
IFLAVSGIHT LNQIFGHCIH QKMRQSKTKQ YFLALSESKK KSCIKSIKWG QLKELLEINF
SSEYISQIIA LPNGLRTKFE PTSTFITVKN CNTISVSGQY FRMMVESPTQ PNFWERMICI
NGFKVMIHID LLKQQMKKLN SLQNWEKLPS AITLENDSWH FSIPHHFEMF KIIDSIPTIF
KSIKQMLYSL KTSKDDLIIF PHKIETPLSL PKIKLKSKRW LFSISDDPLE AELNTIFQIG
LQEQRERLAK LQEFNKRISE DLIKSQKNAK EMKDDFEAID NAILKHRTGL WAKDGKKRLR
KSATDSEIPL TPAALNINGK RDDRPDRTQF ISPEIENAYN TLLANFSDSW IKRVKEYKVK
ERREFDKNFS FLWGFIDYTK LPKDINKKVL PFSTNPFLMN LIIENIDIDI IRPSCGIENI
PNFIHDVGKG VPKNTEYSIM IPMHLDAKFS EVRWHLRDYP LPFVSIPPLS STQSKETIPM
RIYGDFMITE DMLQSDRELR TLFVPLIPSV TVENTDRYYS LFVPRTMTSA KIFTDLNFEI
NSNHTTRVTW GGSYQPAIQQ TMQCLDNFSK PPLDPSVKLG FWDKTRYLFH GKINIVWKKR
GKFEISLKGA KSPYMLGGES AGFIVGFDGN VNLKCNEDND PKKFLSCSAD KVHFSIPNYF
AKPLLVWSRP STNTMFIPNQ DDTNMQRYAS FYYLLNTTSS KNEKADKEIM GKSFIEKTGI
KLSGGMTLDM GILFERLGPS LNERTFESKK HYLTRLCNPI YVQDLSKHDS YAGFRSDFIH
MSFGLSSNSN SAYNAMQLSP NGFKAFFVWW KSFSGNFPVR RGPLFGLQSI SPKFGEHLYT
ISYHADVSPL FINYMYHNAD ADQILRKNYL EVAEFAGLKA KSSHFIMDLH QRKEVLTEYQ
AGLNVRRRVM KLKFLAGDVV CQDVDIRTVS GEFSKLNYIE EKEDAEYDIF DNDMSWLDIT
DFQDAFFINP DNYLPKIKIM PFAFSPQFAY QKRASYGDKY QVDPKTCKPI TPFDNRVSHG
CTLGHNVSLR TDLVEKRVTV LKKFREKLQE GIRKNKSAGV SEENLNDLLS KANSSVENAE
LLLKDFQKIF KQHEAGQTEQ PFHFDSLNLL KNTKKTLKQF EHRFFIFNVL LKWNEDARSA
IFKFFYYANL SNEFASLASG KGLREFEDVI KQREMTDDTT SMEAIPEGTD KANTTKQCHS
CDDTEFTTEN LLNIFEKNIT QLSCDIKNKI HHKFFVQFIT PQIQLTSLEN PEACVLVSSP
FFMLKTLEFD ANTTSNTYMQ DIFLKRHGIL FGNANAFLFN KKDYQEFFEL YFGSSSYGQD
KKEQWPPWLG LELGFEPSAL KKKAVVRNIS ALLHHQKLAP FSAKYDSLKD KIEDNICGYV
PQVNVQVNSD EYLMLTKMAL KLFLYVEPED EELKKYIEKL IIGYDIYDTA QTRKFVNDLH
DSEQILAVVE KELLFKRSLL DDIGKLDLSN IHNERMHQLL RLYILRKVFT SNGNNYINRT
LVWNIKVNET ILHLLDKIDK PFLDIAVAKL NFQRIQHTMG LRKNTVTVKM MQIFDLGENV
NYHCILGPLI TSSGNDTVGL ASDVPLVQIT WDVDKPVGGI KVVKNVETTL SSLTIKLEED
RLNKLFEWLS LKELIYDGNG DDDDGASSIF DMVSSESEEG KIEFSEDISS DFNEMLKRSS
DYMIVEDLKL NSFKLCISYK GKGKMRLANV TNFVFNFPTL RLSNQTLRVT DLLLALKKVL
IKVLIKHTGR FIGNKLKRNS KENKIADDTS PLKQLTTYNS YTEPEELR
