FMP46_YEAST
ID FMP46_YEAST Reviewed; 133 AA.
AC P36141; D6VXB0;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 1.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Putative redox protein FMP46, mitochondrial;
DE EC=1.-.-.-;
DE AltName: Full=Found in mitochondrial proteome protein 46;
DE Flags: Precursor;
GN Name=FMP46; OrderedLocusNames=YKR049C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8196765; DOI=10.1038/369371a0;
RA Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V.,
RA Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P.,
RA Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L.,
RA Daignan-Fornier B., del Rey F., Dion C., Domdey H., Duesterhoeft A.,
RA Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H.,
RA Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L.,
RA Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M.,
RA Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H.,
RA Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J.,
RA Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H.,
RA Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J.,
RA Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S.,
RA Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F.,
RA Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R.,
RA Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W.,
RA Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M.,
RA Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C.,
RA Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H.,
RA Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L.,
RA van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S.,
RA von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M.,
RA Becker I., Mewes H.-W.;
RT "Complete DNA sequence of yeast chromosome XI.";
RL Nature 369:371-378(1994).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [4]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [5]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [6]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 76625 / YPH499;
RX PubMed=14576278; DOI=10.1073/pnas.2135385100;
RA Sickmann A., Reinders J., Wagner Y., Joppich C., Zahedi R.P., Meyer H.E.,
RA Schoenfisch B., Perschil I., Chacinska A., Guiard B., Rehling P.,
RA Pfanner N., Meisinger C.;
RT "The proteome of Saccharomyces cerevisiae mitochondria.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:13207-13212(2003).
RN [7]
RP STRUCTURE BY NMR, AND PUTATIVE FUNCTION.
RX PubMed=16202234; DOI=10.5483/bmbrep.2005.38.5.550;
RA Jung J.-W., Yee A., Wu B., Arrowsmith C.H., Lee W.;
RT "Solution structure of YKR049C, a putative redox protein from Saccharomyces
RT cerevisiae.";
RL J. Biochem. Mol. Biol. 38:550-554(2005).
CC -!- FUNCTION: Putative mitochondrial redox protein which could be involved
CC in the reduction of small toxic molecules.
CC -!- INTERACTION:
CC P36141; P39940: RSP5; NbExp=2; IntAct=EBI-26445, EBI-16219;
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:14562095,
CC ECO:0000269|PubMed:14576278}.
CC -!- MISCELLANEOUS: Present with 1240 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the FMP46 family. {ECO:0000305}.
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DR EMBL; Z28274; CAA82127.1; -; Genomic_DNA.
DR EMBL; AY558316; AAS56642.1; -; Genomic_DNA.
DR EMBL; BK006944; DAA09200.1; -; Genomic_DNA.
DR PIR; S38123; S38123.
DR RefSeq; NP_012975.3; NM_001179839.3.
DR PDB; 1WPI; NMR; -; A=1-133.
DR PDBsum; 1WPI; -.
DR AlphaFoldDB; P36141; -.
DR BMRB; P36141; -.
DR SMR; P36141; -.
DR BioGRID; 34180; 90.
DR IntAct; P36141; 1.
DR MINT; P36141; -.
DR STRING; 4932.YKR049C; -.
DR MaxQB; P36141; -.
DR PaxDb; P36141; -.
DR PRIDE; P36141; -.
DR DNASU; 853923; -.
DR EnsemblFungi; YKR049C_mRNA; YKR049C; YKR049C.
DR GeneID; 853923; -.
DR KEGG; sce:YKR049C; -.
DR SGD; S000001757; FMP46.
DR VEuPathDB; FungiDB:YKR049C; -.
DR eggNOG; ENOG502S4SU; Eukaryota.
DR HOGENOM; CLU_1939538_0_0_1; -.
DR InParanoid; P36141; -.
DR OMA; LWVDWEK; -.
DR BioCyc; YEAST:G3O-32019-MON; -.
DR EvolutionaryTrace; P36141; -.
DR PRO; PR:P36141; -.
DR Proteomes; UP000002311; Chromosome XI.
DR RNAct; P36141; protein.
DR GO; GO:0005739; C:mitochondrion; HDA:SGD.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR InterPro; IPR012882; Fmp46.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR PANTHER; PTHR28071; PTHR28071; 1.
DR Pfam; PF07955; DUF1687; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Mitochondrion; Oxidoreductase; Reference proteome;
KW Transit peptide.
FT TRANSIT 1..21
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 22..133
FT /note="Putative redox protein FMP46, mitochondrial"
FT /id="PRO_0000203215"
FT ACT_SITE 97
FT /evidence="ECO:0000305"
FT STRAND 13..18
FT /evidence="ECO:0007829|PDB:1WPI"
FT STRAND 22..24
FT /evidence="ECO:0007829|PDB:1WPI"
FT HELIX 27..31
FT /evidence="ECO:0007829|PDB:1WPI"
FT TURN 32..35
FT /evidence="ECO:0007829|PDB:1WPI"
FT STRAND 41..48
FT /evidence="ECO:0007829|PDB:1WPI"
FT HELIX 53..61
FT /evidence="ECO:0007829|PDB:1WPI"
FT STRAND 62..65
FT /evidence="ECO:0007829|PDB:1WPI"
FT HELIX 66..73
FT /evidence="ECO:0007829|PDB:1WPI"
FT STRAND 74..76
FT /evidence="ECO:0007829|PDB:1WPI"
FT HELIX 77..80
FT /evidence="ECO:0007829|PDB:1WPI"
FT TURN 81..85
FT /evidence="ECO:0007829|PDB:1WPI"
FT HELIX 86..90
FT /evidence="ECO:0007829|PDB:1WPI"
FT HELIX 95..98
FT /evidence="ECO:0007829|PDB:1WPI"
FT STRAND 109..115
FT /evidence="ECO:0007829|PDB:1WPI"
FT STRAND 118..122
FT /evidence="ECO:0007829|PDB:1WPI"
FT HELIX 123..129
FT /evidence="ECO:0007829|PDB:1WPI"
SQ SEQUENCE 133 AA; 15650 MW; 188F530D3E00FE57 CRC64;
MSFWKTLQRQ PRTISLFTND IASNIKSQKC LQLLKGDVSH RFDVEIANRF PTWDQLQYMR
TSCPQGPVSL QRQIPKLDSV LKYKHTDPTF GMDLQKCVQR GLWNPKEALW VDWENKLVGN
EPADIDKYII QRK
