FMP52_YEAST
ID FMP52_YEAST Reviewed; 231 AA.
AC P40008; D3DLQ0;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Protein FMP52, mitochondrial;
DE AltName: Full=Found in mitochondrial proteome protein 52;
DE Flags: Precursor;
GN Name=FMP52; OrderedLocusNames=YER004W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169868;
RA Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E.,
RA Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E.,
RA Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S.,
RA Hyman R.W., Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D.,
RA Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X.,
RA Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y.,
RA Botstein D., Davis R.W.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome V.";
RL Nature 387:78-81(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [4]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [5]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 76625 / YPH499;
RX PubMed=14576278; DOI=10.1073/pnas.2135385100;
RA Sickmann A., Reinders J., Wagner Y., Joppich C., Zahedi R.P., Meyer H.E.,
RA Schoenfisch B., Perschil I., Chacinska A., Guiard B., Rehling P.,
RA Pfanner N., Meisinger C.;
RT "The proteome of Saccharomyces cerevisiae mitochondria.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:13207-13212(2003).
RN [6]
RP SUBCELLULAR LOCATION, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=16407407; DOI=10.1091/mbc.e05-08-0740;
RA Zahedi R.P., Sickmann A., Boehm A.M., Winkler C., Zufall N.,
RA Schoenfisch B., Guiard B., Pfanner N., Meisinger C.;
RT "Proteomic analysis of the yeast mitochondrial outer membrane reveals
RT accumulation of a subclass of preproteins.";
RL Mol. Biol. Cell 17:1436-1450(2006).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane
CC {ECO:0000269|PubMed:14576278, ECO:0000269|PubMed:16407407}; Peripheral
CC membrane protein {ECO:0000269|PubMed:14576278,
CC ECO:0000269|PubMed:16407407}.
CC -!- MISCELLANEOUS: Present with 1340 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the FMP52 family. {ECO:0000305}.
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DR EMBL; U18778; AAB64537.1; -; Genomic_DNA.
DR EMBL; AY558449; AAS56775.1; -; Genomic_DNA.
DR EMBL; BK006939; DAA07654.1; -; Genomic_DNA.
DR PIR; S50462; S50462.
DR RefSeq; NP_010919.1; NM_001178895.1.
DR AlphaFoldDB; P40008; -.
DR SMR; P40008; -.
DR BioGRID; 36734; 71.
DR DIP; DIP-5295N; -.
DR IntAct; P40008; 3.
DR MINT; P40008; -.
DR STRING; 4932.YER004W; -.
DR iPTMnet; P40008; -.
DR MaxQB; P40008; -.
DR PaxDb; P40008; -.
DR PRIDE; P40008; -.
DR EnsemblFungi; YER004W_mRNA; YER004W; YER004W.
DR GeneID; 856721; -.
DR KEGG; sce:YER004W; -.
DR SGD; S000000806; FMP52.
DR VEuPathDB; FungiDB:YER004W; -.
DR eggNOG; KOG4039; Eukaryota.
DR GeneTree; ENSGT00390000008184; -.
DR HOGENOM; CLU_071330_2_2_1; -.
DR InParanoid; P40008; -.
DR OMA; FCCIGTT; -.
DR BioCyc; YEAST:G3O-30191-MON; -.
DR PRO; PR:P40008; -.
DR Proteomes; UP000002311; Chromosome V.
DR RNAct; P40008; protein.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:SGD.
DR GO; GO:0005741; C:mitochondrial outer membrane; HDA:SGD.
DR GO; GO:0005739; C:mitochondrion; HDA:SGD.
DR GO; GO:0051170; P:import into nucleus; IBA:GO_Central.
DR InterPro; IPR014843; Him1/Fmp52.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR Pfam; PF08732; HIM1; 1.
DR SUPFAM; SSF51735; SSF51735; 1.
PE 1: Evidence at protein level;
KW Membrane; Mitochondrion; Mitochondrion outer membrane; Reference proteome;
KW Transit peptide.
FT TRANSIT 1..44
FT /note="Mitochondrion"
FT CHAIN 45..231
FT /note="Protein FMP52, mitochondrial"
FT /id="PRO_0000202620"
SQ SEQUENCE 231 AA; 25086 MW; 85DBF1DB96358D12 CRC64;
MNGLVLGATG LCGGGFLRHA QEAPQFSKVY AILRRELPFP ATDKVVAIVE RDNSKWSQLI
TNEMNPQVLF TALATTRAAA GGLDKQYKID HDLNLQLAQA AKEKGCETIV LVSSAGAHPD
SRFGYMKMKG EIERDVIALD FKHIIILRPG PLLGERTNSK QSGFGGNLTA ALGTRVYRSR
FQRLLGYPVY GDEVGKVGVH LALNTSGKDK VQFVSSKDIL DISASLEKIA T
