FMR1N_HUMAN
ID FMR1N_HUMAN Reviewed; 255 AA.
AC Q8N0W7; D3DWT3;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=FMR1 neighbor protein {ECO:0000305};
DE AltName: Full=Cancer/testis antigen 37;
DE Short=CT37;
DE AltName: Full=Sarcoma antigen NY-SAR-35;
GN Name=FMR1NB {ECO:0000312|HGNC:HGNC:26372};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=12601173; DOI=10.1073/pnas.0437972100;
RA Lee S.-Y., Obata Y., Yoshida M., Stockert E., Williamson B.,
RA Jungbluth A.A., Chen Y.-T., Old L.J., Scanlan M.J.;
RT "Immunomic analysis of human sarcoma.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:2651-2656(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Testis-specific. Expressed in melanoma, sarcoma,
CC lung, breast, bladder, esophageal and ovarian cancers.
CC {ECO:0000269|PubMed:12601173}.
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DR EMBL; AY211917; AAO65170.1; -; mRNA.
DR EMBL; AK098602; BAC05349.1; -; mRNA.
DR EMBL; CH471171; EAW61291.1; -; Genomic_DNA.
DR EMBL; CH471171; EAW61292.1; -; Genomic_DNA.
DR EMBL; BC034320; AAH34320.1; -; mRNA.
DR CCDS; CCDS14683.1; -.
DR RefSeq; NP_689791.1; NM_152578.2.
DR AlphaFoldDB; Q8N0W7; -.
DR SMR; Q8N0W7; -.
DR BioGRID; 127690; 13.
DR IntAct; Q8N0W7; 9.
DR STRING; 9606.ENSP00000359498; -.
DR iPTMnet; Q8N0W7; -.
DR PhosphoSitePlus; Q8N0W7; -.
DR BioMuta; FMR1NB; -.
DR DMDM; 74728471; -.
DR MassIVE; Q8N0W7; -.
DR PaxDb; Q8N0W7; -.
DR PeptideAtlas; Q8N0W7; -.
DR PRIDE; Q8N0W7; -.
DR ProteomicsDB; 71477; -.
DR Antibodypedia; 549; 115 antibodies from 23 providers.
DR DNASU; 158521; -.
DR Ensembl; ENST00000370467.8; ENSP00000359498.3; ENSG00000176988.9.
DR GeneID; 158521; -.
DR KEGG; hsa:158521; -.
DR MANE-Select; ENST00000370467.8; ENSP00000359498.3; NM_152578.3; NP_689791.1.
DR UCSC; uc004fcm.3; human.
DR CTD; 158521; -.
DR DisGeNET; 158521; -.
DR GeneCards; FMR1NB; -.
DR HGNC; HGNC:26372; FMR1NB.
DR HPA; ENSG00000176988; Tissue enriched (testis).
DR neXtProt; NX_Q8N0W7; -.
DR OpenTargets; ENSG00000176988; -.
DR PharmGKB; PA134927784; -.
DR VEuPathDB; HostDB:ENSG00000176988; -.
DR eggNOG; ENOG502SB9N; Eukaryota.
DR GeneTree; ENSGT00390000007953; -.
DR HOGENOM; CLU_095005_0_0_1; -.
DR InParanoid; Q8N0W7; -.
DR OMA; PIYCCSL; -.
DR OrthoDB; 1422042at2759; -.
DR PhylomeDB; Q8N0W7; -.
DR TreeFam; TF338231; -.
DR PathwayCommons; Q8N0W7; -.
DR SignaLink; Q8N0W7; -.
DR BioGRID-ORCS; 158521; 9 hits in 698 CRISPR screens.
DR GenomeRNAi; 158521; -.
DR Pharos; Q8N0W7; Tbio.
DR PRO; PR:Q8N0W7; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q8N0W7; protein.
DR Bgee; ENSG00000176988; Expressed in right testis and 33 other tissues.
DR ExpressionAtlas; Q8N0W7; baseline and differential.
DR Genevisible; Q8N0W7; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..255
FT /note="FMR1 neighbor protein"
FT /id="PRO_0000281735"
FT TOPO_DOM 1..68
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 69..89
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 90..183
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 184..204
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 205..255
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 125..184
FT /note="P-type"
FT REGION 220..255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 228..242
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 142
FT /note="A -> V (in dbSNP:rs764631)"
FT /id="VAR_031254"
SQ SEQUENCE 255 AA; 29241 MW; E4AAF48D171ED484 CRC64;
MSSHRRKAKG RNRRSHRAMR VAHLELATYE LAATESNPES SHPGYEAAMA DRPQPGWRES
LKMRVSKPFG MLMLSIWILL FVCYYLSYYL CSGSSYFVLA NGHILPNSEN AHGQSLEEDS
ALEALLNFFF PTTCNLRENQ VAKPCNELQD LSESECLRHK CCFSSSGTTS FKCFAPFRDV
PKQMMQMFGL GAISLILVCL PIYCRSLFWR SEPADDLQRQ DNRVVTGLKK QRRKRKRKSE
MLQKAARGRE EHGDE
