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FMR1N_MOUSE
ID   FMR1N_MOUSE             Reviewed;         238 AA.
AC   Q80ZA7; B2RQU9; Q4KL61; Q8BPD4;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Fmr1 neighbor protein {ECO:0000305};
DE   AltName: Full=Protein mNY-SAR-35;
GN   Name=Fmr1nb {ECO:0000312|MGI:MGI:2672032};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC   STRAIN=BALB/cJ; TISSUE=Testis;
RX   PubMed=12601173; DOI=10.1073/pnas.0437972100;
RA   Lee S.-Y., Obata Y., Yoshida M., Stockert E., Williamson B.,
RA   Jungbluth A.A., Chen Y.-T., Old L.J., Scanlan M.J.;
RT   "Immunomic analysis of human sarcoma.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:2651-2656(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   STRAIN=C57BL/6J; TISSUE=Placenta;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Brain, and Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q80ZA7-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q80ZA7-2; Sequence=VSP_024024;
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DR   EMBL; AY214130; AAO59491.1; -; mRNA.
DR   EMBL; AK076190; BAC36243.1; -; mRNA.
DR   EMBL; BC099411; AAH99411.1; -; mRNA.
DR   EMBL; BC138087; AAI38088.1; -; mRNA.
DR   EMBL; BC171923; AAI71923.1; -; mRNA.
DR   CCDS; CCDS30172.1; -. [Q80ZA7-1]
DR   CCDS; CCDS53084.1; -. [Q80ZA7-2]
DR   RefSeq; NP_001160091.1; NM_001166619.1. [Q80ZA7-2]
DR   RefSeq; NP_001160092.1; NM_001166620.1.
DR   RefSeq; NP_778158.2; NM_174993.2.
DR   AlphaFoldDB; Q80ZA7; -.
DR   BioGRID; 228930; 1.
DR   STRING; 10090.ENSMUSP00000071748; -.
DR   iPTMnet; Q80ZA7; -.
DR   PhosphoSitePlus; Q80ZA7; -.
DR   PaxDb; Q80ZA7; -.
DR   PRIDE; Q80ZA7; -.
DR   Antibodypedia; 549; 115 antibodies from 23 providers.
DR   DNASU; 207854; -.
DR   Ensembl; ENSMUST00000069731; ENSMUSP00000064543; ENSMUSG00000062170. [Q80ZA7-2]
DR   GeneID; 207854; -.
DR   KEGG; mmu:207854; -.
DR   UCSC; uc012hji.1; mouse. [Q80ZA7-2]
DR   CTD; 158521; -.
DR   MGI; MGI:2672032; Fmr1nb.
DR   VEuPathDB; HostDB:ENSMUSG00000062170; -.
DR   eggNOG; ENOG502SB9N; Eukaryota.
DR   GeneTree; ENSGT00390000007953; -.
DR   InParanoid; Q80ZA7; -.
DR   OrthoDB; 1422042at2759; -.
DR   BioGRID-ORCS; 207854; 1 hit in 72 CRISPR screens.
DR   ChiTaRS; Fmr1nb; mouse.
DR   PRO; PR:Q80ZA7; -.
DR   Proteomes; UP000000589; Chromosome X.
DR   RNAct; Q80ZA7; protein.
DR   Bgee; ENSMUSG00000062170; Expressed in placenta labyrinth and 37 other tissues.
DR   ExpressionAtlas; Q80ZA7; baseline and differential.
DR   Genevisible; Q80ZA7; MM.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..238
FT                   /note="Fmr1 neighbor protein"
FT                   /id="PRO_0000281736"
FT   TOPO_DOM        1..79
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        80..100
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        101..178
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        179..199
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        200..238
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          118..176
FT                   /note="P-type"
FT   REGION          1..30
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          214..238
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         126..171
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334,
FT                   ECO:0000303|PubMed:16141072"
FT                   /id="VSP_024024"
FT   CONFLICT        232
FT                   /note="E -> K (in Ref. 2; BAC36243)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   238 AA;  27018 MW;  3FBCCC66B53092D4 CRC64;
     MPSDRRPSQR RNRSKSRDYR GARSKVTRAD TRNRDDTLAL SMYQGPPSAD QGNNMADAPR
     FGFWTSVSQC LQYLWARRHL GLLLLLFWTL VILFRPVNTA KLPILAEAAE LEPPLGNMLD
     FFFPTACIIR DNQVVVACNN QPYLSESECL KSKCCSSTSG TIIKCYAPVR DKPTQVLRVF
     GLAAISILVL GFLPMCCCSM CWRRKRMNRM LKVLKKQKSK GKKPKGRKAS EERALLSH
 
 
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