ID   FMRF_ALIVI              Reviewed;           4 AA.
AC   P69146; P01162;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   10-FEB-2021, entry version 24.
DE   RecName: Full=FMRFamide;
OS   Alitta virens (Sandworm) (Nereis virens).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Polychaeta;
OC   Errantia; Phyllodocida; Nereididae; Alitta.
OX   NCBI_TaxID=880429;
RN   [1]
RP   PROTEIN SEQUENCE, AND AMIDATION AT PHE-4.
RX   PubMed=2342992; DOI=10.1016/0196-9781(90)90113-j;
RA   Krajniak K.G., Price D.A.;
RT   "Authentic FMRFamide is present in the polychaete Nereis virens.";
RL   Peptides 11:75-77(1990).
CC   -!- FUNCTION: Myoactive; cardioexcitatory substance. Pharmacological
CC       activities include augmentation, induction, and regularization of
CC       cardiac contraction.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the FARP (FMRFamide related peptide) family.
CC       {ECO:0000305}.
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DR   PIR; A60418; A60418.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Neuropeptide; Secreted.
FT   PEPTIDE         1..4
FT                   /note="FMRFamide"
FT                   /id="PRO_0000043650"
FT   MOD_RES         4
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:2342992"
SQ   SEQUENCE   4 AA;  600 MW;  69D40699A0000000 CRC64;
     FMRF