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FMRF_DOROP
ID   FMRF_DOROP              Reviewed;         331 AA.
AC   Q9GSL0;
DT   08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 35.
DE   RecName: Full=FMRFamide-related neuropeptides {ECO:0000312|EMBL:AAG22544.1};
DE   Contains:
DE     RecName: Full=FIRF-amide {ECO:0000303|PubMed:11060217};
DE   Contains:
DE     RecName: Full=ALSGDAFLRF-amide {ECO:0000303|PubMed:11060217};
DE   Contains:
DE     RecName: Full=FLRF-amide {ECO:0000303|PubMed:11060217};
DE   Contains:
DE     RecName: Full=FMRF-amide 1 {ECO:0000303|PubMed:11060217};
DE   Contains:
DE     RecName: Full=FMRF-amide 2 {ECO:0000303|PubMed:11060217};
DE   Contains:
DE     RecName: Full=FMRF-amide 3 {ECO:0000303|PubMed:11060217};
DE   Contains:
DE     RecName: Full=FMRF-amide 4 {ECO:0000303|PubMed:11060217};
DE   Contains:
DE     RecName: Full=FMRF-amide 5 {ECO:0000303|PubMed:11060217};
DE   Contains:
DE     RecName: Full=FMRF-amide 6 {ECO:0000303|PubMed:11060217};
DE   Contains:
DE     RecName: Full=FMRF-amide 7 {ECO:0000303|PubMed:11060217};
DE   Contains:
DE     RecName: Full=FMRF-amide 8 {ECO:0000303|PubMed:11060217};
DE   Contains:
DE     RecName: Full=FMRF-amide 9 {ECO:0000303|PubMed:11060217};
DE   Contains:
DE     RecName: Full=FMRF-amide 10 {ECO:0000303|PubMed:11060217};
DE   Contains:
DE     RecName: Full=FMRF-amide 11 {ECO:0000303|PubMed:11060217};
DE   Flags: Precursor;
GN   Name=FMRFa {ECO:0000303|PubMed:11060217};
OS   Doryteuthis opalescens (California market squid) (Loligo opalescens).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC   Coleoidea; Decapodiformes; Teuthida; Myopsina; Loliginidae; Doryteuthis.
OX   NCBI_TaxID=1051066;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:AAG22544.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], MASS SPECTROMETRY, AND AMIDATION AT PHE-71;
RP   PHE-83; PHE-100; PHE-174; PHE-181; PHE-200; PHE-211; PHE-222; PHE-242;
RP   PHE-260; PHE-271; PHE-283; PHE-299 AND PHE-318.
RC   TISSUE=Cervicothoracic ganglion {ECO:0000312|EMBL:AAG22544.1};
RX   PubMed=11060217; DOI=10.1242/jeb.203.23.3565;
RA   Sweedler J.V., Li L., Floyd P., Gilly W.;
RT   "Mass spectrometric survey of peptides in cephalopods with an emphasis on
RT   the FMRFamide-related peptides.";
RL   J. Exp. Biol. 203:3565-3573(2000).
CC   -!- FUNCTION: Excitatory neurotransmitters that directly modulate
CC       chromatophore function by activating chromatophore expansion at the
CC       chromatophore neuromuscular junction. {ECO:0000250|UniProtKB:P91889}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P91889}.
CC   -!- MASS SPECTROMETRY: [FIRF-amide]: Mass=581.33; Method=MALDI; Note=FIRF-
CC       amide.; Evidence={ECO:0000269|PubMed:11060217};
CC   -!- MASS SPECTROMETRY: [ALSGDAFLRF-amide]: Mass=1095.6; Method=MALDI;
CC       Note=ALSGDAFLRF-amide.; Evidence={ECO:0000269|PubMed:11060217};
CC   -!- MASS SPECTROMETRY: [FLRF-amide]: Mass=581.33; Method=MALDI; Note=FLRF-
CC       amide.; Evidence={ECO:0000269|PubMed:11060217};
CC   -!- MASS SPECTROMETRY: [FMRF-amide 1]: Mass=599.29; Method=MALDI;
CC       Note=FMRF-amide 1.; Evidence={ECO:0000269|PubMed:11060217};
CC   -!- MASS SPECTROMETRY: [FMRF-amide 2]: Mass=599.29; Method=MALDI;
CC       Note=FMRF-amide 2.; Evidence={ECO:0000269|PubMed:11060217};
CC   -!- MASS SPECTROMETRY: [FMRF-amide 3]: Mass=599.29; Method=MALDI;
CC       Note=FMRF-amide 3.; Evidence={ECO:0000269|PubMed:11060217};
CC   -!- MASS SPECTROMETRY: [FMRF-amide 4]: Mass=599.29; Method=MALDI;
CC       Note=FMRF-amide 4.; Evidence={ECO:0000269|PubMed:11060217};
CC   -!- MASS SPECTROMETRY: [FMRF-amide 5]: Mass=599.29; Method=MALDI;
CC       Note=FMRF-amide 5.; Evidence={ECO:0000269|PubMed:11060217};
CC   -!- MASS SPECTROMETRY: [FMRF-amide 6]: Mass=599.29; Method=MALDI;
CC       Note=FMRF-amide 6.; Evidence={ECO:0000269|PubMed:11060217};
CC   -!- MASS SPECTROMETRY: [FMRF-amide 7]: Mass=599.29; Method=MALDI;
CC       Note=FMRF-amide 7.; Evidence={ECO:0000269|PubMed:11060217};
CC   -!- MASS SPECTROMETRY: [FMRF-amide 8]: Mass=599.29; Method=MALDI;
CC       Note=FMRF-amide 8.; Evidence={ECO:0000269|PubMed:11060217};
CC   -!- MASS SPECTROMETRY: [FMRF-amide 9]: Mass=599.29; Method=MALDI;
CC       Note=FMRF-amide 9.; Evidence={ECO:0000269|PubMed:11060217};
CC   -!- MASS SPECTROMETRY: [FMRF-amide 10]: Mass=599.29; Method=MALDI;
CC       Note=FMRF-amide 10.; Evidence={ECO:0000269|PubMed:11060217};
CC   -!- MASS SPECTROMETRY: [FMRF-amide 11]: Mass=599.29; Method=MALDI;
CC       Note=FMRF-amide 11.; Evidence={ECO:0000269|PubMed:11060217};
CC   -!- SIMILARITY: Belongs to the FARP (FMRFamide related peptide) family.
CC       {ECO:0000255}.
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DR   EMBL; AF303160; AAG22544.1; -; mRNA.
DR   AlphaFoldDB; Q9GSL0; -.
DR   SMR; Q9GSL0; -.
DR   PRIDE; Q9GSL0; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR002544; FMRFamid-related_peptide-like.
DR   Pfam; PF01581; FARP; 14.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Neuropeptide; Repeat;
KW   Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   PROPEP          26..65
FT                   /evidence="ECO:0000269|PubMed:11060217"
FT                   /id="PRO_0000403999"
FT   PEPTIDE         68..71
FT                   /note="FIRF-amide"
FT                   /evidence="ECO:0000269|PubMed:11060217"
FT                   /id="PRO_0000404000"
FT   PEPTIDE         74..83
FT                   /note="ALSGDAFLRF-amide"
FT                   /evidence="ECO:0000269|PubMed:11060217"
FT                   /id="PRO_0000404001"
FT   PROPEP          86..94
FT                   /evidence="ECO:0000269|PubMed:11060217"
FT                   /id="PRO_0000404002"
FT   PEPTIDE         97..100
FT                   /note="FLRF-amide"
FT                   /evidence="ECO:0000269|PubMed:11060217"
FT                   /id="PRO_0000404003"
FT   PROPEP          103..168
FT                   /evidence="ECO:0000269|PubMed:11060217"
FT                   /id="PRO_0000404004"
FT   PEPTIDE         171..174
FT                   /note="FMRF-amide 1"
FT                   /evidence="ECO:0000269|PubMed:11060217"
FT                   /id="PRO_0000404005"
FT   PEPTIDE         178..181
FT                   /note="FMRF-amide 2"
FT                   /evidence="ECO:0000269|PubMed:11060217"
FT                   /id="PRO_0000404006"
FT   PROPEP          184..194
FT                   /evidence="ECO:0000269|PubMed:11060217"
FT                   /id="PRO_0000404007"
FT   PEPTIDE         197..200
FT                   /note="FMRF-amide 3"
FT                   /evidence="ECO:0000269|PubMed:11060217"
FT                   /id="PRO_0000404008"
FT   PROPEP          203..205
FT                   /evidence="ECO:0000269|PubMed:11060217"
FT                   /id="PRO_0000404009"
FT   PEPTIDE         208..211
FT                   /note="FMRF-amide 4"
FT                   /evidence="ECO:0000269|PubMed:11060217"
FT                   /id="PRO_0000404010"
FT   PROPEP          214..216
FT                   /evidence="ECO:0000269|PubMed:11060217"
FT                   /id="PRO_0000404011"
FT   PEPTIDE         219..222
FT                   /note="FMRF-amide 5"
FT                   /evidence="ECO:0000269|PubMed:11060217"
FT                   /id="PRO_0000404012"
FT   PROPEP          225..236
FT                   /evidence="ECO:0000269|PubMed:11060217"
FT                   /id="PRO_0000404013"
FT   PEPTIDE         239..242
FT                   /note="FMRF-amide 6"
FT                   /evidence="ECO:0000269|PubMed:11060217"
FT                   /id="PRO_0000404014"
FT   PROPEP          245..254
FT                   /evidence="ECO:0000269|PubMed:11060217"
FT                   /id="PRO_0000404015"
FT   PEPTIDE         257..260
FT                   /note="FMRF-amide 7"
FT                   /evidence="ECO:0000269|PubMed:11060217"
FT                   /id="PRO_0000404016"
FT   PROPEP          263..265
FT                   /evidence="ECO:0000269|PubMed:11060217"
FT                   /id="PRO_0000404017"
FT   PEPTIDE         268..271
FT                   /note="FMRF-amide 8"
FT                   /evidence="ECO:0000269|PubMed:11060217"
FT                   /id="PRO_0000404018"
FT   PROPEP          274..277
FT                   /evidence="ECO:0000269|PubMed:11060217"
FT                   /id="PRO_0000404019"
FT   PEPTIDE         280..283
FT                   /note="FMRF-amide 9"
FT                   /evidence="ECO:0000269|PubMed:11060217"
FT                   /id="PRO_0000404020"
FT   PROPEP          286..293
FT                   /evidence="ECO:0000269|PubMed:11060217"
FT                   /id="PRO_0000404021"
FT   PEPTIDE         296..299
FT                   /note="FMRF-amide 10"
FT                   /evidence="ECO:0000269|PubMed:11060217"
FT                   /id="PRO_0000404022"
FT   PROPEP          302..312
FT                   /evidence="ECO:0000269|PubMed:11060217"
FT                   /id="PRO_0000404023"
FT   PEPTIDE         315..318
FT                   /note="FMRF-amide 11"
FT                   /evidence="ECO:0000269|PubMed:11060217"
FT                   /id="PRO_0000404024"
FT   PROPEP          321..331
FT                   /evidence="ECO:0000269|PubMed:11060217"
FT                   /id="PRO_0000404025"
FT   REGION          122..158
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          279..310
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        134..149
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         71
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:11060217"
FT   MOD_RES         83
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:11060217"
FT   MOD_RES         100
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:11060217"
FT   MOD_RES         174
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:11060217"
FT   MOD_RES         181
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:11060217"
FT   MOD_RES         200
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:11060217"
FT   MOD_RES         211
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:11060217"
FT   MOD_RES         222
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:11060217"
FT   MOD_RES         242
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:11060217"
FT   MOD_RES         260
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:11060217"
FT   MOD_RES         271
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:11060217"
FT   MOD_RES         283
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:11060217"
FT   MOD_RES         299
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:11060217"
FT   MOD_RES         318
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:11060217"
SQ   SEQUENCE   331 AA;  38692 MW;  C204EB87E2C81DA9 CRC64;
     MRCWSPCSLL VVIVIYCLSS HTSEAFDLAQ ACVESQRLSL LPICDTIFAV QQEGVQQSAD
     DGMRSKRFIR FGRALSGDAF LRFGKNVPDL PFEDKRFLRF GRAAPQLDEL LKQALQRVES
     LQKADETSVR RKRSTDAAPQ NNAENPEQKN DSAKITKRYI DDVEDSDVKR FMRFGKRFMR
     FGRNPSDVGN KLTEKRFMRF GRDPEKRFMR FGKSDDKRFM RFGRNPSDAE DELEEDKRFM
     RFGRGGEDDE EEAEKRFMRF GRDPEKKFMR FGKSGEDKRF MRFGRNPDEQ EADKRFMRFG
     RGGEDDEVST EDKRFMRFGR SADKCKGCLE G
 
 
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