ID   FMRF_MACNI              Reviewed;           4 AA.
AC   P69145; P01162;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 26.
DE   RecName: Full=FMRFamide {ECO:0000303|PubMed:877582, ECO:0000303|PubMed:909875};
DE   AltName: Full=Cardioexcitatory neuropeptide {ECO:0000303|PubMed:877582, ECO:0000303|PubMed:909875};
DE   AltName: Full=Peak C {ECO:0000303|PubMed:877582, ECO:0000303|PubMed:909875};
OS   Macrocallista nimbosa (Sun-ray clam).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC   Autobranchia; Heteroconchia; Euheterodonta; Imparidentia; Neoheterodontei;
OC   Venerida; Veneroidea; Veneridae; Macrocallista.
OX   NCBI_TaxID=6594;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, AMIDATION AT PHE-4, SYNTHESIS, AND SUBCELLULAR
RP   LOCATION.
RC   TISSUE=Cerebral pedal, and Ganglion;
RX   PubMed=877582; DOI=10.1126/science.877582;
RA   Price D.A., Greenberg M.J.;
RT   "Structure of a molluscan cardioexcitatory neuropeptide.";
RL   Science 197:670-671(1977).
RN   [2]
RP   PROTEIN SEQUENCE, FUNCTION, AND SUBCELLULAR LOCATION.
RC   TISSUE=Ganglion;
RX   PubMed=909875; DOI=10.1080/00327487708061643;
RA   Price D.A., Greenberg M.J.;
RT   "Purification and characterization of a cardioexcitatory neuropeptide from
RT   the central ganglia of a bivalve mollusc.";
RL   Prep. Biochem. 7:261-281(1977).
CC   -!- FUNCTION: Myoactive; cardioexcitatory substance. Pharmacological
CC       activities include augmentation, induction, and regularization of
CC       cardiac contraction. {ECO:0000269|PubMed:877582,
CC       ECO:0000269|PubMed:909875}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:877582,
CC       ECO:0000269|PubMed:909875}.
CC   -!- SIMILARITY: Belongs to the FARP (FMRFamide related peptide) family.
CC       {ECO:0000305}.
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DR   PIR; A01426; ECNK.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Neuropeptide; Secreted.
FT   PEPTIDE         1..4
FT                   /note="FMRFamide"
FT                   /evidence="ECO:0000269|PubMed:877582,
FT                   ECO:0000269|PubMed:909875"
FT                   /id="PRO_0000043649"
FT   MOD_RES         4
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:877582"
SQ   SEQUENCE   4 AA;  600 MW;  69D40699A0000000 CRC64;
     FMRF