ID   FMS3_ECOLX              Reviewed;         168 AA.
AC   P15488;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1990, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=CS3 fimbrial subunit A;
DE   AltName: Full=CS3 pilin;
DE   Flags: Precursor;
OS   Escherichia coli.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PARTIAL PROTEIN SEQUENCE.
RC   STRAIN=PB176 / ETEC;
RX   PubMed=2576094; DOI=10.1111/j.1365-2958.1989.tb00154.x;
RA   Jalajakumari M.B., Thomas C.J., Halter R., Manning P.A.;
RT   "Genes for biosynthesis and assembly of CS3 pili of CFA/II enterotoxigenic
RT   Escherichia coli: novel regulation of pilus production by bypassing an
RT   amber codon.";
RL   Mol. Microbiol. 3:1685-1695(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ETEC;
RX   PubMed=2903130; DOI=10.1128/iai.56.12.3297-3300.1988;
RA   Boylan M., Smyth C.J., Scott J.R.;
RT   "Nucleotide sequence of the gene encoding the major subunit of CS3 fimbriae
RT   of enterotoxigenic Escherichia coli.";
RL   Infect. Immun. 56:3297-3300(1988).
RN   [3]
RP   PROTEIN SEQUENCE OF 23-45.
RC   STRAIN=E9034A;
RX   PubMed=2572583; DOI=10.1128/jb.171.11.6372-6374.1989;
RA   Hall R.H., Maneval D.R. Jr., Collins J.H., Theibert J.L., Levine M.M.;
RT   "Purification and analysis of colonization factor antigen I, coli surface
RT   antigen 1, and coli surface antigen 3 fimbriae from enterotoxigenic
RT   Escherichia coli.";
RL   J. Bacteriol. 171:6372-6374(1989).
CC   -!- FUNCTION: Fimbriae (also called pili), polar filaments radiating from
CC       the surface of the bacterium to a length of 0.5-1.5 micrometers and
CC       numbering 100-300 per cell, enable bacteria to colonize the epithelium
CC       of specific host organs.
CC   -!- SUBCELLULAR LOCATION: Fimbrium.
CC   -!- PTM: A longer minor form, starting at amino acid 15, has been detected
CC       by amino acid sequencing. This is probably due to alternative
CC       processing of the signal peptide.
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DR   EMBL; X16944; CAA34820.1; -; Genomic_DNA.
DR   EMBL; M35657; AAA23614.1; -; Genomic_DNA.
DR   PIR; A34952; A34952.
DR   RefSeq; WP_013188494.1; NZ_JTGK01000084.1.
DR   AlphaFoldDB; P15488; -.
DR   GO; GO:0009289; C:pilus; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Fimbrium; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000269|PubMed:2572583,
FT                   ECO:0000269|PubMed:2576094"
FT   CHAIN           23..168
FT                   /note="CS3 fimbrial subunit A"
FT                   /id="PRO_0000009181"
FT   CONFLICT        83
FT                   /note="N -> S (in Ref. 2; AAA23614)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   168 AA;  17492 MW;  F9CDA7B7306E3263 CRC64;
     MLKIKYLLIG LSLSAMSSYS LAAAGPTLTK ELALNVLSPA ALDATWAPQD NLTLSNTGVS
     NTLVGVLTLS NTSIDTVSIA STNVSDTSKN GTVTFAHETN NSASFATTIS TDNANITLDK
     NAGNTIVKTT NGSQLPTNLP LKFITTEGNE HLVSGNYRAN ITITSTIK