ID   FMS5_ECOLX              Reviewed;         203 AA.
AC   P33781;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=CS5 fimbrial subunit;
DE   AltName: Full=CS5 pilin;
DE   AltName: Full=Colonization factor antigen IV;
DE            Short=CFA/IV;
DE   AltName: Full=PCF8775;
DE   Flags: Precursor;
OS   Escherichia coli.
OG   Plasmid.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=O115:H40 / ETEC;
RX   PubMed=1371766; DOI=10.1128/iai.60.3.1254-1257.1992;
RA   Clark C.A., Heuzenroeder M.W., Manning P.A.;
RT   "Colonization factor antigen CFA/IV (PCF8775) of human enterotoxigenic
RT   Escherichia coli: nucleotide sequence of the CS5 determinant.";
RL   Infect. Immun. 60:1254-1257(1992).
RN   [2]
RP   PROTEIN SEQUENCE OF 23-52.
RC   STRAIN=O115:H40 / ETEC;
RX   PubMed=2568574; DOI=10.1111/j.1365-2958.1989.tb00175.x;
RA   Heuzenroeder M.W., Elliot T.R., Thomas C.J., Halter R., Manning P.A.;
RT   "Characterization and molecular cloning of the PCF8775 CS5 antigen from an
RT   enterotoxigenic Escherichia coli 0115:H40 isolated in Central Australia.";
RL   Mol. Microbiol. 3:303-310(1989).
CC   -!- FUNCTION: Major subunit of fimbriae. Fimbriae (also called pili), are
CC       polar filaments radiating from the surface of the bacterium to a length
CC       of 0.5-1.5 micrometers and numbering 100-300 per cell. They enable
CC       bacteria to colonize the epithelium of specific host organs.
CC   -!- SUBCELLULAR LOCATION: Fimbrium.
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DR   EMBL; X63411; CAA45008.1; -; Genomic_DNA.
DR   PIR; A43856; A43856.
DR   RefSeq; WP_000739895.1; NZ_UGCI01000001.1.
DR   AlphaFoldDB; P33781; -.
DR   GO; GO:0009289; C:pilus; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Fimbrium; Plasmid; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000269|PubMed:2568574"
FT   CHAIN           23..203
FT                   /note="CS5 fimbrial subunit"
FT                   /id="PRO_0000009186"
SQ   SEQUENCE   203 AA;  20847 MW;  6621278D8505C7E8 CRC64;
     MKKNLLITSV LAMATVSGSV LAAVTNGQLT FNWQGVVPSA PVTQSSWAFV NGLDIPFTPG
     TEQLNITLDS NKDITARSVK PYDFFIVPVS GNVTPGAPVT RDTSANINSV NAFLSSVPVS
     NGFVGNKQLT LSTAVEAAKG EVAITLNGQA LKVGSASPTV VTVASNKKES HISIDMNAKA
     AAADVAEGAA INFVAPVTFA VDI