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FMT_COXBU
ID   FMT_COXBU               Reviewed;         314 AA.
AC   Q83AA8;
DT   04-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Methionyl-tRNA formyltransferase {ECO:0000255|HAMAP-Rule:MF_00182};
DE            EC=2.1.2.9 {ECO:0000255|HAMAP-Rule:MF_00182};
GN   Name=fmt {ECO:0000255|HAMAP-Rule:MF_00182}; OrderedLocusNames=CBU_1997;
OS   Coxiella burnetii (strain RSA 493 / Nine Mile phase I).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Legionellales; Coxiellaceae;
OC   Coxiella.
OX   NCBI_TaxID=227377;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RSA 493 / Nine Mile phase I;
RX   PubMed=12704232; DOI=10.1073/pnas.0931379100;
RA   Seshadri R., Paulsen I.T., Eisen J.A., Read T.D., Nelson K.E., Nelson W.C.,
RA   Ward N.L., Tettelin H., Davidsen T.M., Beanan M.J., DeBoy R.T.,
RA   Daugherty S.C., Brinkac L.M., Madupu R., Dodson R.J., Khouri H.M.,
RA   Lee K.H., Carty H.A., Scanlan D., Heinzen R.A., Thompson H.A., Samuel J.E.,
RA   Fraser C.M., Heidelberg J.F.;
RT   "Complete genome sequence of the Q-fever pathogen, Coxiella burnetii.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:5455-5460(2003).
CC   -!- FUNCTION: Attaches a formyl group to the free amino group of methionyl-
CC       tRNA(fMet). The formyl group appears to play a dual role in the
CC       initiator identity of N-formylmethionyl-tRNA by promoting its
CC       recognition by IF2 and preventing the misappropriation of this tRNA by
CC       the elongation apparatus. {ECO:0000255|HAMAP-Rule:MF_00182}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) =
CC         (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-
CC         tRNA(fMet); Xref=Rhea:RHEA:24380, Rhea:RHEA-COMP:9952, Rhea:RHEA-
CC         COMP:9953, ChEBI:CHEBI:15378, ChEBI:CHEBI:57453, ChEBI:CHEBI:57454,
CC         ChEBI:CHEBI:78530, ChEBI:CHEBI:78844; EC=2.1.2.9;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00182};
CC   -!- SIMILARITY: Belongs to the Fmt family. {ECO:0000255|HAMAP-
CC       Rule:MF_00182}.
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DR   EMBL; AE016828; AAO91486.1; -; Genomic_DNA.
DR   RefSeq; NP_820972.1; NC_002971.3.
DR   RefSeq; WP_010958586.1; NZ_CCYB01000066.1.
DR   PDB; 3TQQ; X-ray; 2.00 A; A=1-314.
DR   PDBsum; 3TQQ; -.
DR   AlphaFoldDB; Q83AA8; -.
DR   SMR; Q83AA8; -.
DR   STRING; 227377.CBU_1997; -.
DR   DNASU; 1209910; -.
DR   EnsemblBacteria; AAO91486; AAO91486; CBU_1997.
DR   GeneID; 1209910; -.
DR   KEGG; cbu:CBU_1997; -.
DR   PATRIC; fig|227377.7.peg.1984; -.
DR   eggNOG; COG0223; Bacteria.
DR   HOGENOM; CLU_033347_1_2_6; -.
DR   OMA; CCPVVAY; -.
DR   Proteomes; UP000002671; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0004479; F:methionyl-tRNA formyltransferase activity; IBA:GO_Central.
DR   GO; GO:0071951; P:conversion of methionyl-tRNA to N-formyl-methionyl-tRNA; IBA:GO_Central.
DR   CDD; cd08646; FMT_core_Met-tRNA-FMT_N; 1.
DR   CDD; cd08704; Met_tRNA_FMT_C; 1.
DR   Gene3D; 3.10.25.10; -; 1.
DR   HAMAP; MF_00182; Formyl_trans; 1.
DR   InterPro; IPR005794; Fmt.
DR   InterPro; IPR005793; Formyl_trans_C.
DR   InterPro; IPR037022; Formyl_trans_C_sf.
DR   InterPro; IPR002376; Formyl_transf_N.
DR   InterPro; IPR036477; Formyl_transf_N_sf.
DR   InterPro; IPR011034; Formyl_transferase-like_C_sf.
DR   InterPro; IPR001555; GART_AS.
DR   InterPro; IPR044135; Met-tRNA-FMT_C.
DR   InterPro; IPR041711; Met-tRNA-FMT_N.
DR   Pfam; PF02911; Formyl_trans_C; 1.
DR   Pfam; PF00551; Formyl_trans_N; 1.
DR   SUPFAM; SSF50486; SSF50486; 1.
DR   SUPFAM; SSF53328; SSF53328; 1.
DR   TIGRFAMs; TIGR00460; fmt; 1.
DR   PROSITE; PS00373; GART; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Protein biosynthesis; Reference proteome; Transferase.
FT   CHAIN           1..314
FT                   /note="Methionyl-tRNA formyltransferase"
FT                   /id="PRO_0000082955"
FT   BINDING         111..114
FT                   /ligand="(6S)-5,6,7,8-tetrahydrofolate"
FT                   /ligand_id="ChEBI:CHEBI:57453"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00182"
FT   STRAND          4..9
FT                   /evidence="ECO:0007829|PDB:3TQQ"
FT   HELIX           12..14
FT                   /evidence="ECO:0007829|PDB:3TQQ"
FT   HELIX           15..23
FT                   /evidence="ECO:0007829|PDB:3TQQ"
FT   STRAND          24..32
FT                   /evidence="ECO:0007829|PDB:3TQQ"
FT   HELIX           49..56
FT                   /evidence="ECO:0007829|PDB:3TQQ"
FT   STRAND          67..69
FT                   /evidence="ECO:0007829|PDB:3TQQ"
FT   HELIX           70..77
FT                   /evidence="ECO:0007829|PDB:3TQQ"
FT   STRAND          82..88
FT                   /evidence="ECO:0007829|PDB:3TQQ"
FT   HELIX           95..98
FT                   /evidence="ECO:0007829|PDB:3TQQ"
FT   STRAND          105..111
FT                   /evidence="ECO:0007829|PDB:3TQQ"
FT   TURN            113..116
FT                   /evidence="ECO:0007829|PDB:3TQQ"
FT   STRAND          117..119
FT                   /evidence="ECO:0007829|PDB:3TQQ"
FT   HELIX           121..128
FT                   /evidence="ECO:0007829|PDB:3TQQ"
FT   STRAND          131..139
FT                   /evidence="ECO:0007829|PDB:3TQQ"
FT   STRAND          142..145
FT                   /evidence="ECO:0007829|PDB:3TQQ"
FT   STRAND          149..156
FT                   /evidence="ECO:0007829|PDB:3TQQ"
FT   HELIX           163..187
FT                   /evidence="ECO:0007829|PDB:3TQQ"
FT   HELIX           197..199
FT                   /evidence="ECO:0007829|PDB:3TQQ"
FT   HELIX           208..211
FT                   /evidence="ECO:0007829|PDB:3TQQ"
FT   HELIX           219..228
FT                   /evidence="ECO:0007829|PDB:3TQQ"
FT   TURN            229..233
FT                   /evidence="ECO:0007829|PDB:3TQQ"
FT   STRAND          236..239
FT                   /evidence="ECO:0007829|PDB:3TQQ"
FT   STRAND          242..252
FT                   /evidence="ECO:0007829|PDB:3TQQ"
FT   STRAND          263..267
FT                   /evidence="ECO:0007829|PDB:3TQQ"
FT   STRAND          270..274
FT                   /evidence="ECO:0007829|PDB:3TQQ"
FT   STRAND          276..286
FT                   /evidence="ECO:0007829|PDB:3TQQ"
FT   HELIX           295..302
FT                   /evidence="ECO:0007829|PDB:3TQQ"
FT   HELIX           303..305
FT                   /evidence="ECO:0007829|PDB:3TQQ"
FT   TURN            308..310
FT                   /evidence="ECO:0007829|PDB:3TQQ"
SQ   SEQUENCE   314 AA;  34288 MW;  11A4B3CCB9ED0AD8 CRC64;
     MSLKIVFAGT PQFAVPTLRA LIDSSHRVLA VYTQPDRPSG RGQKIMESPV KEIARQNEIP
     IIQPFSLRDE VEQEKLIAMN ADVMVVVAYG LILPKKALNA FRLGCVNVHA SLLPRWRGAA
     PIQRAILAGD RETGISIMQM NEGLDTGDVL AKSACVISSE DTAADLHDRL SLIGADLLLE
     SLAKLEKGDI KLEKQDEASA TYASKIQKQE ALIDWRKSAV EIARQVRAFN PTPIAFTYFE
     GQPMRIWRAT VVDEKTDFEP GVLVDADKKG ISIAAGSGIL RLHQLQLPGK RVCSAGDFIN
     AHGDKLIPGK TVFG
 
 
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