AL7A1_DICDI
ID AL7A1_DICDI Reviewed; 509 AA.
AC P83401; Q550M6; Q8MYH7;
DT 15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 15-NOV-2002, sequence version 2.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Putative aldehyde dehydrogenase family 7 member A1 homolog;
DE EC=1.2.1.3;
DE AltName: Full=Antiquitin-1;
GN ORFNames=DDB_G0276821;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH;
CC Xref=Rhea:RHEA:16185, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17478, ChEBI:CHEBI:29067, ChEBI:CHEBI:57540,
CC ChEBI:CHEBI:57945; EC=1.2.1.3;
CC -!- SUBUNIT: Homotetramer. {ECO:0000250|UniProtKB:P83402}.
CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000019; EAL68912.1; -; Genomic_DNA.
DR RefSeq; XP_642906.1; XM_637814.1.
DR AlphaFoldDB; P83401; -.
DR SMR; P83401; -.
DR STRING; 44689.DDB0231504; -.
DR PaxDb; P83401; -.
DR EnsemblProtists; EAL68912; EAL68912; DDB_G0276821.
DR GeneID; 8620772; -.
DR KEGG; ddi:DDB_G0276821; -.
DR dictyBase; DDB_G0276821; -.
DR eggNOG; KOG2453; Eukaryota.
DR HOGENOM; CLU_005391_1_2_1; -.
DR InParanoid; P83401; -.
DR OMA; DAWKVYM; -.
DR PhylomeDB; P83401; -.
DR Reactome; R-DDI-6798163; Choline catabolism.
DR Reactome; R-DDI-71064; Lysine catabolism.
DR PRO; PR:P83401; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0031012; C:extracellular matrix; HDA:dictyBase.
DR GO; GO:0045335; C:phagocytic vesicle; HDA:dictyBase.
DR GO; GO:0004029; F:aldehyde dehydrogenase (NAD+) activity; ISS:UniProtKB.
DR GO; GO:0043878; F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity; IEA:UniProtKB-EC.
DR GO; GO:0006081; P:cellular aldehyde metabolic process; ISS:UniProtKB.
DR Gene3D; 3.40.309.10; -; 1.
DR Gene3D; 3.40.605.10; -; 1.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR029510; Ald_DH_CS_GLU.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR InterPro; IPR044638; ALDH7A1-like.
DR PANTHER; PTHR43521; PTHR43521; 1.
DR Pfam; PF00171; Aldedh; 1.
DR SUPFAM; SSF53720; SSF53720; 1.
DR PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE 3: Inferred from homology;
KW NAD; Oxidoreductase; Reference proteome.
FT CHAIN 1..509
FT /note="Putative aldehyde dehydrogenase family 7 member A1
FT homolog"
FT /id="PRO_0000056500"
FT ACT_SITE 266
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10007"
FT ACT_SITE 300
FT /note="Nucleophile"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10007"
FT BINDING 244..249
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000250"
FT SITE 164
FT /note="Transition state stabilizer"
FT /evidence="ECO:0000250"
SQ SEQUENCE 509 AA; 55190 MW; DD104624407CFC41 CRC64;
MTTFNEYPFL AELGIKAENN DGVFNGKWGG AGEIIKCLNP TNNKVIATVR GAAPEEYETC
IQAMLAAKVK WALTPAPRRG EIVRLIGQAM REKIEPLSKL ISLEMGKIYI EAKGEVQEFI
DVCDYATGLS RSINGQVMPS ERPNHILMET WNPLGLVGII TAFNFPCAVL GWNAAISMIC
GNVQLWKGAS TTSLITLAVS KIIEKVLVEN DVDPAVCCVL IGPGRTVGEQ MIQDKRFGLI
SFTGSTEVGR RISSTVHGYF GKTILELGGN NAIVVAEDAD IELVLRAVLF ASVGTTGQRC
TTCRRLFVHE SLYDTILERL TKAYKTIKIG NPLEEGVLVG PLHTQSAVKE FTEGLEEIKK
QGGKVVIGGN KLDISGGNFV EPTVVAIEHD APIVKTELFV PILYIMKFKN LDDAFAWNNE
VPQGLSSSLF TNNQKNIFKW LGPTGSDCGI VNVNVATNGA EIGGAFGGEK ETGGGRESGS
DSWKQYCRRS TNTINYGNTM PLSQGINFN
