AL7B4_ARATH
ID AL7B4_ARATH Reviewed; 508 AA.
AC Q9SYG7; Q546B7;
DT 15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 15-NOV-2002, sequence version 3.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Aldehyde dehydrogenase family 7 member B4;
DE EC=1.2.1.3;
DE AltName: Full=Antiquitin-1;
DE AltName: Full=Turgor-responsive ALDH;
GN Name=ALDH7B4; OrderedLocusNames=At1g54100; ORFNames=F15I1.19;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|EMBL:AAD25783.1};
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND INDUCTION.
RX PubMed=15830124; DOI=10.1007/s11103-004-7796-6;
RA Kirch H.-H., Schlingensiepen S., Kotchoni S., Sunkar R., Bartels D.;
RT "Detailed expression analysis of selected genes of the aldehyde
RT dehydrogenase(ALDH) gene superfamily in Arabidopsis thaliana.";
RL Plant Mol. Biol. 57:315-332(2005).
RN [2] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3] {ECO:0000305}
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NOMENCLATURE.
RX PubMed=15358267; DOI=10.1016/j.tplants.2004.06.004;
RA Kirch H.-H., Bartels D., Wei Y., Schnable P.S., Wood A.J.;
RT "The ALDH gene superfamily of Arabidopsis.";
RL Trends Plant Sci. 9:371-377(2004).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH;
CC Xref=Rhea:RHEA:16185, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17478, ChEBI:CHEBI:29067, ChEBI:CHEBI:57540,
CC ChEBI:CHEBI:57945; EC=1.2.1.3;
CC -!- SUBUNIT: Homotetramer. {ECO:0000250|UniProtKB:P83402}.
CC -!- INDUCTION: By abscisic acid (ABA) and dehydration in roots and
CC plantlets, and by salt stress in plantlets.
CC {ECO:0000269|PubMed:15830124}.
CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC {ECO:0000305}.
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DR EMBL; AJ584645; CAE48164.1; -; mRNA.
DR EMBL; AC006577; AAD25783.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE33048.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE33049.1; -; Genomic_DNA.
DR EMBL; AY048242; AAK82504.1; -; mRNA.
DR EMBL; AF378873; AAK55676.1; -; mRNA.
DR EMBL; AY091032; AAM13853.1; -; mRNA.
DR EMBL; AY102145; AAM26712.1; -; mRNA.
DR EMBL; AY117345; AAM51420.1; -; mRNA.
DR EMBL; AK230363; BAF02162.1; -; mRNA.
DR PIR; H96581; H96581.
DR RefSeq; NP_175812.1; NM_104287.5.
DR RefSeq; NP_849807.1; NM_179476.3.
DR AlphaFoldDB; Q9SYG7; -.
DR SMR; Q9SYG7; -.
DR BioGRID; 27074; 2.
DR STRING; 3702.AT1G54100.1; -.
DR PaxDb; Q9SYG7; -.
DR PRIDE; Q9SYG7; -.
DR ProteomicsDB; 244867; -.
DR EnsemblPlants; AT1G54100.1; AT1G54100.1; AT1G54100.
DR EnsemblPlants; AT1G54100.2; AT1G54100.2; AT1G54100.
DR GeneID; 841849; -.
DR Gramene; AT1G54100.1; AT1G54100.1; AT1G54100.
DR Gramene; AT1G54100.2; AT1G54100.2; AT1G54100.
DR KEGG; ath:AT1G54100; -.
DR Araport; AT1G54100; -.
DR TAIR; locus:2014380; AT1G54100.
DR eggNOG; KOG2453; Eukaryota.
DR HOGENOM; CLU_005391_1_2_1; -.
DR InParanoid; Q9SYG7; -.
DR OMA; DAWKVYM; -.
DR OrthoDB; 692580at2759; -.
DR PhylomeDB; Q9SYG7; -.
DR BioCyc; ARA:AT1G54100-MON; -.
DR PRO; PR:Q9SYG7; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9SYG7; baseline and differential.
DR Genevisible; Q9SYG7; AT.
DR GO; GO:0004029; F:aldehyde dehydrogenase (NAD+) activity; ISS:UniProtKB.
DR GO; GO:0043878; F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity; IEA:UniProtKB-EC.
DR GO; GO:0006081; P:cellular aldehyde metabolic process; ISS:UniProtKB.
DR GO; GO:0009737; P:response to abscisic acid; IEP:TAIR.
DR GO; GO:0009269; P:response to desiccation; IEP:TAIR.
DR GO; GO:0009651; P:response to salt stress; IEP:TAIR.
DR Gene3D; 3.40.309.10; -; 1.
DR Gene3D; 3.40.605.10; -; 1.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR029510; Ald_DH_CS_GLU.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR InterPro; IPR044638; ALDH7A1-like.
DR PANTHER; PTHR43521; PTHR43521; 1.
DR Pfam; PF00171; Aldedh; 1.
DR SUPFAM; SSF53720; SSF53720; 1.
DR PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE 2: Evidence at transcript level;
KW NAD; Oxidoreductase; Reference proteome; Stress response.
FT CHAIN 1..508
FT /note="Aldehyde dehydrogenase family 7 member B4"
FT /id="PRO_0000056495"
FT ACT_SITE 266
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10007"
FT ACT_SITE 300
FT /note="Nucleophile"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10007"
FT BINDING 244..249
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000250"
FT SITE 165
FT /note="Transition state stabilizer"
FT /evidence="ECO:0000250"
SQ SEQUENCE 508 AA; 54208 MW; 7690BB8D906B263A CRC64;
MGSANNEYEF LSEIGLTSHN LGSYVAGKWQ ANGPLVSTLN PANNQPIAQV VEASLEDYEQ
GLKACEEAAK IWMQVTAPKR GDIVRQIGDA LRSKLDYLGR LLSLEMGKIL AEGIGEVQEV
IDMCDFAVGL SRQLNGSVIP SERPNHMMLE MWNPLGIVGV ITAFNFPCAV LGWNACIALV
CGNCVVWKGA PTTPLITIAM TKLVAEVLEK NNLPGAIFTA MCGGAEIGEA IAKDTRIPLV
SFTGSSRVGS MVQQTVNARS GKTLLELSGN NAIIVMDDAD IQLAARSVLF AAVGTAGQRC
TTCRRLLLHE SVYDKVLEQL LTSYKQVKIG NPLEKGTLLG PLHTPESKKN FEKGIEVIKS
QGGKILTGGK AVEGEGNFVE PTIIEISADA AVVKEELFAP VLYVLKFKSF GEAVAINNSV
PQGLSSSIFT RNPENIFRWI GPLGSDCGIV NVNIPTNGAE IGGAFGGEKA TGGGREAGSD
SWKQYMRRST CTINYGNELP LAQGINFG
