FMT_RICAU
ID FMT_RICAU Reviewed; 73 AA.
AC O33510;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 25-MAY-2022, entry version 67.
DE RecName: Full=Methionyl-tRNA formyltransferase {ECO:0000250|UniProtKB:P23882};
DE EC=2.1.2.9 {ECO:0000250|UniProtKB:P23882};
DE Flags: Fragment;
GN Name=fmt;
OS Rickettsia australis.
OC Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
OX NCBI_TaxID=787;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Andersson S.G.E., Stothard D.R., Romedenne M., Viseur N., Fuerst P.,
RA Kurland C.G.;
RT "Rearrangement of the rRNA genes in Rickettsia preceeded the divergence of
RT the typhus and the spotted fever group Rickettsia.";
RL Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Attaches a formyl group to the free amino group of methionyl-
CC tRNA(fMet). The formyl group appears to play a dual role in the
CC initiator identity of N-formylmethionyl-tRNA by promoting its
CC recognition by IF2 and preventing the misappropriation of this tRNA by
CC the elongation apparatus. {ECO:0000250|UniProtKB:P23882}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) =
CC (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-
CC tRNA(fMet); Xref=Rhea:RHEA:24380, Rhea:RHEA-COMP:9952, Rhea:RHEA-
CC COMP:9953, ChEBI:CHEBI:15378, ChEBI:CHEBI:57453, ChEBI:CHEBI:57454,
CC ChEBI:CHEBI:78530, ChEBI:CHEBI:78844; EC=2.1.2.9;
CC Evidence={ECO:0000250|UniProtKB:P23882};
CC -!- SIMILARITY: Belongs to the Fmt family. {ECO:0000305}.
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DR EMBL; Y13130; CAA73597.1; -; Genomic_DNA.
DR AlphaFoldDB; O33510; -.
DR SMR; O33510; -.
DR GO; GO:0004479; F:methionyl-tRNA formyltransferase activity; IEA:UniProtKB-EC.
DR CDD; cd08704; Met_tRNA_FMT_C; 1.
DR Gene3D; 3.10.25.10; -; 1.
DR InterPro; IPR005793; Formyl_trans_C.
DR InterPro; IPR037022; Formyl_trans_C_sf.
DR InterPro; IPR011034; Formyl_transferase-like_C_sf.
DR InterPro; IPR044135; Met-tRNA-FMT_C.
DR Pfam; PF02911; Formyl_trans_C; 1.
DR SUPFAM; SSF50486; SSF50486; 1.
PE 3: Inferred from homology;
KW Protein biosynthesis; Transferase.
FT CHAIN <1..73
FT /note="Methionyl-tRNA formyltransferase"
FT /id="PRO_0000083027"
FT NON_TER 1
SQ SEQUENCE 73 AA; 8241 MW; A8D47C6565166389 CRC64;
YFSYNDKVIK ILEAEYLNTN HHFTAGTVIS DKLEIACGSG ILQVQKLQQE SKKALNVEEF
LRGTNILKAT ILK