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FMT_RICRH
ID   FMT_RICRH               Reviewed;          73 AA.
AC   O33545;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Methionyl-tRNA formyltransferase {ECO:0000250|UniProtKB:P23882};
DE            EC=2.1.2.9 {ECO:0000250|UniProtKB:P23882};
DE   Flags: Fragment;
GN   Name=fmt;
OS   Rickettsia rhipicephali.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
OX   NCBI_TaxID=33992;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Andersson S.G.E., Stothard D.R., Romedenne M., Viseur N., Fuerst P.,
RA   Kurland C.G.;
RT   "Rearrangement of the rRNA genes in Rickettsia preceeded the divergence of
RT   the typhus and the spotted fever group Rickettsia.";
RL   Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Attaches a formyl group to the free amino group of methionyl-
CC       tRNA(fMet). The formyl group appears to play a dual role in the
CC       initiator identity of N-formylmethionyl-tRNA by promoting its
CC       recognition by IF2 and preventing the misappropriation of this tRNA by
CC       the elongation apparatus. {ECO:0000250|UniProtKB:P23882}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) =
CC         (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-
CC         tRNA(fMet); Xref=Rhea:RHEA:24380, Rhea:RHEA-COMP:9952, Rhea:RHEA-
CC         COMP:9953, ChEBI:CHEBI:15378, ChEBI:CHEBI:57453, ChEBI:CHEBI:57454,
CC         ChEBI:CHEBI:78530, ChEBI:CHEBI:78844; EC=2.1.2.9;
CC         Evidence={ECO:0000250|UniProtKB:P23882};
CC   -!- SIMILARITY: Belongs to the Fmt family. {ECO:0000305}.
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DR   EMBL; Y13128; CAA73595.1; -; Genomic_DNA.
DR   AlphaFoldDB; O33545; -.
DR   SMR; O33545; -.
DR   GO; GO:0004479; F:methionyl-tRNA formyltransferase activity; IEA:UniProtKB-EC.
DR   CDD; cd08704; Met_tRNA_FMT_C; 1.
DR   Gene3D; 3.10.25.10; -; 1.
DR   InterPro; IPR005793; Formyl_trans_C.
DR   InterPro; IPR037022; Formyl_trans_C_sf.
DR   InterPro; IPR011034; Formyl_transferase-like_C_sf.
DR   InterPro; IPR044135; Met-tRNA-FMT_C.
DR   Pfam; PF02911; Formyl_trans_C; 1.
DR   SUPFAM; SSF50486; SSF50486; 1.
PE   3: Inferred from homology;
KW   Protein biosynthesis; Transferase.
FT   CHAIN           <1..73
FT                   /note="Methionyl-tRNA formyltransferase"
FT                   /id="PRO_0000083034"
FT   NON_TER         1
SQ   SEQUENCE   73 AA;  8261 MW;  7485296F9E48EB64 CRC64;
     YFSYNDKIIK ILEAEYLNAD HHFTSGTVIS DKLEIACGSG ILRVKKLQQE SKKALNIEEF
     LCGTNILKDT VLK
 
 
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