FN3C1_MOUSE
ID FN3C1_MOUSE Reviewed; 1356 AA.
AC Q6DFV6;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Fibronectin type III domain containing protein 3C1;
GN Name=Fndc3c1; Synonyms=Fndc3c, Gm784;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=16904100; DOI=10.1016/j.ydbio.2006.06.054;
RA Obholz K.L., Akopyan A., Waymire K.G., MacGregor G.R.;
RT "FNDC3A is required for adhesion between spermatids and Sertoli cells.";
RL Dev. Biol. 298:498-513(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Eye, and Head;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the FNDC3 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DQ192038; ABA82151.1; -; mRNA.
DR EMBL; AL807795; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC076625; AAH76625.1; -; mRNA.
DR EMBL; BC085176; AAH85176.1; -; mRNA.
DR CCDS; CCDS30342.1; -.
DR RefSeq; NP_001007581.1; NM_001007580.1.
DR RefSeq; XP_006528166.1; XM_006528103.3.
DR RefSeq; XP_006528167.1; XM_006528104.3.
DR RefSeq; XP_006528169.1; XM_006528106.3.
DR RefSeq; XP_017174016.1; XM_017318527.1.
DR AlphaFoldDB; Q6DFV6; -.
DR SMR; Q6DFV6; -.
DR STRING; 10090.ENSMUSP00000038678; -.
DR iPTMnet; Q6DFV6; -.
DR PhosphoSitePlus; Q6DFV6; -.
DR PaxDb; Q6DFV6; -.
DR PeptideAtlas; Q6DFV6; -.
DR PRIDE; Q6DFV6; -.
DR DNASU; 333564; -.
DR Ensembl; ENSMUST00000039447; ENSMUSP00000038678; ENSMUSG00000033737.
DR GeneID; 333564; -.
DR KEGG; mmu:333564; -.
DR UCSC; uc009ubs.1; mouse.
DR CTD; 333564; -.
DR MGI; MGI:2685630; Fndc3c1.
DR VEuPathDB; HostDB:ENSMUSG00000033737; -.
DR eggNOG; ENOG502SGM2; Eukaryota.
DR GeneTree; ENSGT00940000163592; -.
DR HOGENOM; CLU_004152_0_0_1; -.
DR InParanoid; Q6DFV6; -.
DR OMA; YSHGRAN; -.
DR OrthoDB; 633003at2759; -.
DR PhylomeDB; Q6DFV6; -.
DR TreeFam; TF316401; -.
DR BioGRID-ORCS; 333564; 3 hits in 72 CRISPR screens.
DR ChiTaRS; Fndc3c1; mouse.
DR PRO; PR:Q6DFV6; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q6DFV6; protein.
DR Bgee; ENSMUSG00000033737; Expressed in 1st arch mandibular component and 80 other tissues.
DR ExpressionAtlas; Q6DFV6; baseline and differential.
DR Genevisible; Q6DFV6; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 7.
DR Gene3D; 2.60.40.10; -; 8.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR Pfam; PF00041; fn3; 5.
DR SMART; SM00060; FN3; 8.
DR SUPFAM; SSF49265; SSF49265; 5.
DR PROSITE; PS50853; FN3; 8.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix.
FT CHAIN 1..1356
FT /note="Fibronectin type III domain containing protein 3C1"
FT /id="PRO_0000379879"
FT TRANSMEM 1330..1350
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1351..1356
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 454..549
FT /note="Fibronectin type-III 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 553..648
FT /note="Fibronectin type-III 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 650..741
FT /note="Fibronectin type-III 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 745..842
FT /note="Fibronectin type-III 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 914..1007
FT /note="Fibronectin type-III 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 1017..1103
FT /note="Fibronectin type-III 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 1104..1199
FT /note="Fibronectin type-III 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 1202..1299
FT /note="Fibronectin type-III 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT REGION 303..341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 356..402
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 428..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 825..894
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1299..1320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 367..400
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 825..844
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1356 AA; 149712 MW; BB76247C293C1855 CRC64;
MEHQLSPILS EIPPTVPVIN GEPMCPVENY LLDPNAMAVC SNHSQIMTQH KMYNTWTCPQ
YWSQIVFVQV NPGEILTIKA DDGSIQNIQG PADVPLIAPT GNLPPIYLPP GYMSQVVEEN
GIQKIVIVPQ TLDYHVPMTA PVQQPFVAAP LLTYPQAPQL LYSPVQGEIP VPSYIQEPQQ
IPPLPLLPPL PLLPPAATFL FQEHLETYPQ GRVNHNQFDE RTVKIGEYSK KKIRDRQLGE
HKINSTFSDT TLLLNKDIDM PAPPDSLCPY TVDTAPGTNT DNSTSDTYSL NTVLNTCTID
SAPRNMADNI PDTNTTDTIT SSSAHTPSIS TSNATFCSDN NNNITDSSIS NYNQVTYDET
HKPPDAKSIP SCTSQSASNP SVSENAHNPS SINDGLRPSD VASISENDHE ETEANMGAGD
NKQILGENQK KSQSSNASLK EHNTEDRTQP GCFNIEKPVV SNIQTRSATV SWTRKSNEKY
DINSSMTHEL ALSSNGKNGT YKNIYTGNGV TVVLHDLQPC MVYFLRVTTI RNAEHRSVSE
VVSFTTPGCE PDPPLAPTLI SRTKNSLSLQ WKASNDNGSK ISSFLLEWDE GKGEDFKSCY
SGRLKQHKLF KLNPSTKYSF RLAAKNDFGC SNFSETAVFY TSGKTPPAPL PPKLKEAGIY
SLSLEWCAPT NPNPNDTLTY VLEMEEAKSG LGFKPKYNGE DLTCTIRNLQ RNTMYKFRIF
AYNLEGRSNP SGEVKYTTRP ARPGCPNKPY VVGTIHAHQV TIGWDLPKDN GGMNISSYSL
EVCENSDSAN LWKIIYSGTR QEFLYDDLQA ATTYKLRVFC TSPAGQSRPS DVLTIQTPTL
PPESCRSQPL RGKTKSKDAN LPDNRSVNGK PEAHVRGKKA KGPHQDRKVH PSSEKKCALG
SQSMECGSVP ARHPPSQCGT PVLTCKGPTC VIVSWEIPKC NGAEIIDYRL QWGQVEDSMH
LIYTGPCLRY EVKGLVPATT YFCRVQAVNI VGVGMFGGTA KVTTPGTVPA MVPVLKEVES
KVPAKLSSTC IAIRWEEPDC HGSPITGYNI EYGDKKVVTV KRITEYVLKD LQPNTTYRIR
IQAINHYGLS PFSPSIRCKT KPLPPEPPQL NCVVYGHQSL RLKWGTVSSK KTLANFINYN
VLMEDRSGRF SVIYRGPDVT HKVQKLSEYT EYKFKIQACN EAGEGPESDI YTFTTTKSPP
TALKAPKVHP LNNNSCEIKW ESLEPIKGDP IVYCLQVTTG KKANQIYKGP NTSFSFSNYH
ANSRYRFKVC AGRRYETSNG LQELWGPYSP SALFSTYKHH SGHGKGSGSK GKGNHNDKGE
KCKTEMSDDT FVLTLLIGFA LIAVLCAVAV QYLLIN
