FND10_HUMAN
ID FND10_HUMAN Reviewed; 226 AA.
AC F2Z333;
DT 21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT 31-MAY-2011, sequence version 1.
DT 03-AUG-2022, entry version 60.
DE RecName: Full=Fibronectin type III domain-containing protein 10;
DE Flags: Precursor;
GN Name=FNDC10; Synonyms=C1orf233;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
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DR EMBL; AL691432; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS55559.1; -.
DR RefSeq; NP_001229588.1; NM_001242659.1.
DR AlphaFoldDB; F2Z333; -.
DR BioGRID; 569217; 2.
DR STRING; 9606.ENSP00000389111; -.
DR GlyGen; F2Z333; 2 sites.
DR PhosphoSitePlus; F2Z333; -.
DR BioMuta; FNDC10; -.
DR MassIVE; F2Z333; -.
DR MaxQB; F2Z333; -.
DR PaxDb; F2Z333; -.
DR PeptideAtlas; F2Z333; -.
DR PRIDE; F2Z333; -.
DR ProteomicsDB; 23877; -.
DR DNASU; 643988; -.
DR Ensembl; ENST00000422725.4; ENSP00000389111.1; ENSG00000228594.4.
DR GeneID; 643988; -.
DR KEGG; hsa:643988; -.
DR MANE-Select; ENST00000422725.4; ENSP00000389111.1; NM_001242659.2; NP_001229588.1.
DR UCSC; uc021oes.2; human.
DR CTD; 643988; -.
DR GeneCards; FNDC10; -.
DR HGNC; HGNC:42951; FNDC10.
DR HPA; ENSG00000228594; Tissue enhanced (adrenal gland, brain).
DR neXtProt; NX_F2Z333; -.
DR OpenTargets; ENSG00000228594; -.
DR VEuPathDB; HostDB:ENSG00000228594; -.
DR eggNOG; ENOG502S019; Eukaryota.
DR GeneTree; ENSGT00550000076432; -.
DR HOGENOM; CLU_097198_0_0_1; -.
DR InParanoid; F2Z333; -.
DR OMA; TYTRFPC; -.
DR OrthoDB; 1099174at2759; -.
DR PhylomeDB; F2Z333; -.
DR TreeFam; TF332961; -.
DR PathwayCommons; F2Z333; -.
DR BioGRID-ORCS; 643988; 27 hits in 1057 CRISPR screens.
DR ChiTaRS; FNDC10; human.
DR GenomeRNAi; 643988; -.
DR Pharos; F2Z333; Tdark.
DR PRO; PR:F2Z333; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; F2Z333; protein.
DR Bgee; ENSG00000228594; Expressed in right adrenal gland cortex and 138 other tissues.
DR Genevisible; F2Z333; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR034446; Fndc10.
DR PANTHER; PTHR39233; PTHR39233; 1.
DR Pfam; PF17742; DUF5579; 1.
PE 3: Inferred from homology;
KW Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..226
FT /note="Fibronectin type III domain-containing protein 10"
FT /id="PRO_0000416238"
FT TOPO_DOM 21..182
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 183..203
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 204..226
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 74..166
FT /note="Fibronectin type-III"
FT CARBOHYD 86
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 109
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 226 AA; 24218 MW; F4A076C9226DA5FE CRC64;
MRAPPLLLLL AACAPPPCAA AAPTPPGWEP TPDAPWCPYK VLPEGPEAGG GRLCFRSPAR
GFRCQAPGCV LHAPAGRSLR ASVLRNRSVL LQWRLAPAAA RRVRAFALNC SWRGAYTRFP
CERVLLGASC RDYLLPDVHD SVLYRLCLQP LPLRAGPAAA APETPEPAEC VEFTAEPAGM
QDIVVAMTAV GGSICVMLVV ICLLVAYITE NLMRPALARP GLRRHP
