FND10_MOUSE
ID FND10_MOUSE Reviewed; 223 AA.
AC A2A9Q0; Q8BXK6;
DT 21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 79.
DE RecName: Full=Fibronectin type III domain-containing protein 10;
DE Flags: Precursor;
GN Name=Fndc10;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Adrenal gland;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC32775.1; Type=Frameshift; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK046537; BAC32775.1; ALT_FRAME; mRNA.
DR EMBL; AL627405; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL670236; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS57321.1; -.
DR RefSeq; NP_848814.3; NM_178699.4.
DR AlphaFoldDB; A2A9Q0; -.
DR SMR; A2A9Q0; -.
DR STRING; 10090.ENSMUSP00000096871; -.
DR GlyGen; A2A9Q0; 2 sites.
DR PhosphoSitePlus; A2A9Q0; -.
DR PaxDb; A2A9Q0; -.
DR PeptideAtlas; A2A9Q0; -.
DR PRIDE; A2A9Q0; -.
DR ProteomicsDB; 271786; -.
DR DNASU; 230991; -.
DR Ensembl; ENSMUST00000099265; ENSMUSP00000096871; ENSMUSG00000074738.
DR GeneID; 230991; -.
DR KEGG; mmu:230991; -.
DR UCSC; uc008wei.2; mouse.
DR CTD; 643988; -.
DR MGI; MGI:2444790; Fndc10.
DR VEuPathDB; HostDB:ENSMUSG00000074738; -.
DR eggNOG; ENOG502S019; Eukaryota.
DR GeneTree; ENSGT00550000076432; -.
DR HOGENOM; CLU_097198_0_0_1; -.
DR InParanoid; A2A9Q0; -.
DR OMA; TYTRFPC; -.
DR OrthoDB; 1099174at2759; -.
DR TreeFam; TF332961; -.
DR BioGRID-ORCS; 230991; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Fndc10; mouse.
DR PRO; PR:A2A9Q0; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; A2A9Q0; protein.
DR Bgee; ENSMUSG00000074738; Expressed in external carotid artery and 224 other tissues.
DR Genevisible; A2A9Q0; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR034446; Fndc10.
DR PANTHER; PTHR39233; PTHR39233; 1.
DR Pfam; PF17742; DUF5579; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..223
FT /note="Fibronectin type III domain-containing protein 10"
FT /id="PRO_0000416239"
FT TOPO_DOM 20..179
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 180..200
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 201..223
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 72..168
FT /note="Fibronectin type-III"
FT CARBOHYD 86
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 109
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 223 AA; 24417 MW; 81ACDA51A00050E1 CRC64;
MRAPPLLLLL AACAPPSGAA VDPTPPGWEP APDAPWCPYK VLSEGPETGG GRLCFRSPVR
GFRCQTPGCE TLASAGGSLR AHVLRNRSVL LQWRLAPAEA RRVRVFALNC SWRGTYTRFP
CDRVLLGASC RDYLLPDVHD SVRYRLCLQQ LPLRAEVAVV PPELAECVEF TAEPAAMQEI
VVAMTAVGGS ICVMLVVICL LVAYITENLM HPTFRRPSLR RQP
